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MYH2
| Symbol: | MYH2 | | Name(s): | myosin, heavy chain 2, skeletal muscle, adult | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | MYH2A, MYHSA2, MYHas8, MyHC-2A, MyHC-IIa | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 12235157 |
Data suggest that changes in intracellular calcium may play a role in shifts in myosin heavy chain IIa (MyHC IIa) expression during muscle activation. |
| 11889243 |
investigated the relation between expression of the mutant MyHC IIa and pathologic changes in muscle |
| 15741996 |
analysis of normal variation indicates that there is strong selective pressure against mutations in MYH2; On the basis of these results, we suggest that MyHC genes should be regarded as candidate genes in hereditary myopathies of unknown etiology. |
| 17005402 |
Our results provide evidence that the pathogenesis of the MyHC IIa E706K myopathy involves defective function of the mutated myosin as well as alterations in the structural integrity of all muscle cells irrespective of MyHC isoform expression. |
| 15496418 |
IRF-2 is involved in up-regulation of nonmuscle myosin heavy chain II-A gene expression in cell differentiation |
Interacting gene products |
| Interaction Type |
Gene 1 |
Gene 2 |
Interaction description |
Complex |
Publication Link |
| HPRD | adenosine monophosphate deaminase 1 | myosin, heavy chain 2, skeletal muscle, adult | - | - | Pubmed |
| HPRD | adenosine monophosphate deaminase 1 | myosin, heavy chain 2, skeletal muscle, adult | - | - | Pubmed |
| HPRD | myosin, heavy chain 2, skeletal muscle, adult | Protein kinase C epsilon | - | - | Pubmed |
| HPRD | myosin, heavy chain 2, skeletal muscle, adult | S100 calcium-binding protein A4 | - | - | Pubmed |
Recent Publications on MYH2: |  |
An altered phenotype in a conditional knockout of Pitx2 in extraocular muscle.
PURPOSE: To determine the temporal and spatial expression of Pitx2, a... | 3rd October, 2009
| Department of Neurology and Psychiatry, Saint Louis University, St. Louis,
| Invest Ophthalmol Vis Sci. 2009 Oct;50(10):4531-41. Epub 2009 Apr 30.
DOI Direct Link |
Thick filament diseases.
Hereditary myosin myopathies are a newly emerged group of diseases caused... | 21st February, 2009
| Department of Pathology, Sahlgrenska University Hospital, Goteborg,
| Adv Exp Med Biol. 2008;642:78-91.
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Biomechanical signals upregulate myogenic gene induction in the presence or absence of inflammation.
Inflammation of the muscle invariably leads to muscle cell damage and... | 31st August, 2007
| Section of Oral Biology, The Ohio State University College of Dentistry,
| Am J Physiol Cell Physiol. 2007 Jul;293(1):C267-76. Epub 2007 Mar 28.
DOI Direct Link |
A 10-gene classifier for distinguishing head and neck squamous cell carcinoma and lung squamous cell carcinoma.
PURPOSE: The risk of developing metastatic squamous cell carcinoma for... | 19th August, 2007
| University of Pennsylvania Medical Center, Philadelphia, Pennsylvania,
| Clin Cancer Res. 2007 May 15;13(10):2905-15.
DOI Direct Link |
Hereditary myosin myopathies.
Hereditary myosin myopathies have emerged as a new group of muscle... | 25th July, 2007
| Department of Pathology, Sahlgrenska University Hospital, S-413 45
| Neuromuscul Disord. 2007 May;17(5):355-67. Epub 2007 Apr 16.
DOI Direct Link |
→View more research publications. |
MYH2 results (if any) from reagent suppliers | 
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MYH2 (A4.74) Antibody sc-53095
MYH2 shRNA (h) Lentiviral Particles, sc-106273-V, 200 µl ... Western blot analysis of MYH2 expression in RD (A) and L6 (B) whole cell lysates. ...
http://www.scbt.com/datasheet-53095-MYH2-a4-74-antibody.html...
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M1570 Monoclonal Anti-Myosin (Skeletal, Fast) antibody produced in ...
MYH1(4619), MYH2(4620). rat ... Myh1(287408), Myh2(691644). mouse ... Myh1(17879 ), Myh2(17882). shipped in, dry ice. storage temp. −20°C ...
http://www.sigmaaldrich.com/catalog/ProductDetail.do?D7=0&N5...
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MYH2 (N2.261) Antibody sc-53096
MYH2 shRNA (h) Lentiviral Particles, sc-106273-V, 200 µl ... Western blot analysis of MYH2 expression in rat skeletal muscle tissue extract. Download ...
http://www.scbt.com/datasheet-53096-myh2-n2-261-antibody.htm...
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Myosin Antibody / Myosin Antibodies
MYH2 (6D596) Antibody, sc-71631, mouse IgG1, FL (h), WB, IP, IF, m, r, h, rabbit ..... MYH2 shRNA (h) Lentiviral Particles: sc-106273-V ...
http://www.scbt.com/table-myosin.html...
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Myosin IIa (6D595) Antibody sc-71632
MYH2 shRNA (h) Lentiviral Particles, sc-106273-V, 200 µl ... MYH2 (6D595): sc- 71632. Western blot analysis of MYH2 expression in rat skeletal tissue extract
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http://www.scbt.com/datasheet-71632-myosin-iia-6d595-antibod...
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MYH2 (A4.74) Antibody sc-53095
MYH2 (A4.74) Anticorpo sc-53095 MYH2 (A4.74) Antibody sc-53095.
http://www.scbt.com/pt/datasheet-53095-MYH2-a4-74-antibody.h...
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