Thursday November 26 2009 | Biotechnology feed | All feeds

BioPortfolio Biotechnology Pharmaceutical Healthcare Medical Life Science Drug Discovery Disease

MYH10


Suggest Content
Advertise Here
Gene DB Home
Symbol:MYH10
Name(s):myosin, heavy chain 10, non-muscle
Type:protein-coding
Organism:Homo sapiens
Synonyms:MGC134913, MGC134914, NMMHCB
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18182116 MHC expression profile in the CXMDJ diaphragm differed from that in mdx mice. This indicates the dystrophic dog is a more appropriate model to investiagte respiratory failure in dystrophin deficiency.
17727819 downregulation of myosin II-B, the major myosin isoform in neurons, is able to increase Abeta deposition, concomitantly altering the subcellular localization of APP
17202408 The N-terminal 57 residues (N-57) and C-terminal 63 residues (C-63) of C-terminal 305-residue rod fragment of the myosin IIB heavy chain (BRF305) are involved in self-recognition when myosin IIB molecules assemble into homo-filament.
15845534 mutations and alternative splicing alter the enzymatic and motile activity of nonmuscle myosins II-B and II-C
16257837 SMemb/NMMHC-B is expressed in proliferating smooth muscle cells and correlates with phenotypic changes from a contractive to a proliferative type. The stromal cells of the prostate play a role in the regulation of prostatic growth and function.
17020881 myosin IIA and IIB isoforms are regulated by different signaling pathways to perform distinct cellular activities
17023528 estrogen increases NMM-II-B MgATPase activity independent of NMM-II-B filamentation status
15628858 Assessment of solubility of a series of truncated recombinant rod fragments of nonmuscle myosin IIB at various concentrations of NaCl.
15619008 In leukocytes, the activity of non-muscle myosin II is essential for cell migration, and it is not essential for tumor cell migration.
16611744 Myosin II-B resides in a complex with p21-activated kinase 1 (PAK1) and atypical protein kinase C (PKC) zeta (aPKCzeta) and the interaction between these proteins is EGF-dependent.

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDmyosin, heavy polypeptide 10, non-muscleS100 calcium-binding protein A4--Pubmed
HPRDmyosin, heavy polypeptide 10, non-muscleB-cell receptor-associated protein 31--Pubmed
HPRDmyosin, heavy polypeptide 10, non-muscleB-cell receptor-associated protein 31--Pubmed

Recent Publications on MYH10:

Pubmed Logo
Alternative splice variants of MYH9.
MYH9 encodes a class II nonmuscle myosin heavy chain-A (NMHC-IIA), a...
17th June, 2008
Laboratory of Molecular Otology, Department of Otolaryngology, New York DNA Cell Biol. 2008 Mar;27(3):117-25.
DOI Direct Link
Replacement of nonmuscle myosin II-B with II-A rescues brain but not cardiac defects in mice.
The purpose of these studies was to learn whether one isoform of nonmuscle...
21st September, 2007
Laboratory of Molecular Cardiology and Transgenic Core, NHLBI, National J Biol Chem. 2007 Jul 27;282(30):22102-11. Epub 2007 May 22.
DOI Direct Link
Functional analysis on the 5'-flanking region of carp fast skeletal myosin heavy chain genes for their expression at different temperatures.
Two types of the fast skeletal myosin heavy chain (MYH) genes were cloned...
24th June, 2006
Laboratory of Aquatic Molecular Biology and Biotechnology, Graduate School Gene. 2006 May 10;372:82-91. Epub 2006 Feb 10.
DOI Direct Link
Disease-associated mutations and alternative splicing alter the enzymatic and motile activity of nonmuscle myosins II-B and II-C.
Human families with single amino acid mutations in nonmuscle myosin heavy...
20th July, 2005
Laboratory of Molecular Cardiology and Laboratory of Molecular Physiology, J Biol Chem. 2005 Jun 17;280(24):22769-75. Epub 2005 Apr 20.
DOI Direct Link
A novel myosin heavy chain gene in human chromosome 19q13.3.
A human myosin heavy chain gene was identified in chromosome 19q13 by...
11th October, 2003
Institute of Human Genetics, University of Erlangen-Nuremberg, Gene. 2003 Jul 17;312:165-71.

View more research publications.

Patents:

Patents logo
US Patent No.Title
7598052 Expression profile of thyroid cancer
6607879 Compositions for the detection of blood cell and immunological response gene expression
6753314 Protein-protein complexes and methods of using same
6794137 Gene markers useful for detecting skin damage in response to ultraviolet radiation
6846642 Methods of detecting cancer based on prostasin

View more patents.

MYH10 results (if any) from reagent suppliers

Google CSE Logo
MYH10 (N-17) Antibody sc-47205
goat polyclonal IgG, 200µg/ml; epitope mapping at the N-terminus of MYH10 of human origin; recommended for detection of MYH10 of m, r and h origin by WB, ...
http://www.scbt.com/datasheet-47205-MYH10-n-17-antibody.html...

Thumbshot
Myosin II Isoform Antibody Sampler Kit #5144
The heavy chains (NMHCs) are encoded by three genes, MYH9, MYH10 and MYH14, which generate three different nonmuscle myosin II isoforms, IIa, IIb and IIc,
...
http://www.cellsignal.com/products/5144.html...

Thumbshot
MYH10 (H-46) Antibody sc-99210
MYH10 (H-46) Antikörper sc-99210 MYH10 (H-46) Antibody sc-99210.
http://www.scbt.com/de/datasheet-99210-myh10-h-46-antibody.h...

Thumbshot
Myosin IIa Antibody
MYH9, MYH10 and MYH14, which generate three different nonmuscle myosin II isoforms, IIa, IIb and IIc, respectively. (reviewed in 1). ...
http://www.cellsignal.com/pdf/3403.pdf...

Thumbshot
Myosin Antibody / Myosin Antibodies
MYH10 (D-17) Antibody, sc-47204, goat IgG, N-terminus (h), WB, IP, IF, ELISA ... MYH10 (H-46) Antibody, sc-99210, rabbit IgG, 851-896 (h), WB, IP, IF, ELISA ...
http://www.scbt.com/table-myosin.html...

Thumbshot
MYH10 siRNA (h) sc-61122
Click here for details. suitable control antibody: MYH10 (N-17): sc-47205; sqRT- PCR Primer also available: MYH10 (h)-PR: sc-61122-PR, 20 µl ...
http://www.scbt.com/ko/datasheet-61122-MYH10-sirna-h.html...

Thumbshot
MYH10 (N-17) Antibody sc-47205
MYH10 (N-17) Anticuerpo sc-47205 MYH10 (N-17) Antibody sc-47205.
http://www.scbt.com/es/datasheet-47205-MYH10-n-17-antibody.h...

Thumbshot

Search Bioportfolio and other Life Science Sites for MYH10, or search for MYH10 on BioPortfolio's antibody search engine.
This page has been viewed 126 times
Recent Search Terms used to find this page:
nmmvgmymjh10 | nmm myh10 | nmmvgmymjh10 | sigma MYH10 | MYH10 MYH9 MYH14 | myh10 apoptosis | Anti-Myosin IIB non-muscle antibody | NMHC IIB MYH10 | myh10 alternative splicing | .


Resources from the NCBI used on this page, NCBI's standard disclaimer applies.

 

Nothing in this website should be used in place of personal medical advice from your own qualified medical practitioner.

All rights reserved. All other trademarks recognized.
Copyright 1997-2009 - BioPortfolio Limited.