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MYOD1


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Gene DB Home
Symbol:MYOD1
Name(s):myogenic differentiation 1
Type:protein-coding
Organism:Homo sapiens
Synonyms:MYF3, MYOD, PUM
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17693064 Expression of both the endogenous MyoD gene and a reporter gene driven by MyoD regulatory elements is similar in wild-type and homozygous null Gig1(nlacZ) transgenic MyoD1 mouse embryos.
12105204 The myogenic basic helix-loop-helix family of transcription factors, MyoD, Myf5, myogenin, and MRF4, can each activate the muscle differentiation program.
15163661 MyoD modulates the rate of Id1 degradation and suggest a dynamic interplay of these factors
15251938 Hypermethylation of MYOD1 is statistically significantly associated with poor disease outcome in cervical cancer.
16007194 degradation is modulated by E12 and E47
14767572 MYOD1 hypermethylation plays an important role in colorectal cancer and may be a novel prognostic factor.
17014844 MyoD below a threshold level and its displacement from the mitotic chromatin could present another window in the cell cycle for resetting the myogenic transcriptional program and to maintain the myogenic determination of the proliferating cells.
16099183 This review highlights studies of molecular mechanisms by which the muscle-specific myogenic basic helix-loop-helix protein MyoD interacts with other regulatory factors to coordinate gene expression in a controlled and ordered manner.
17378682 MYOD1 is a positive diagnostic for biliary tract rhabdomyosarcoma.
16435141 The expression of MyoD1 was more sensitive but less specific in patients with rhabdomyosarcoma.

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
BINDB-cell translocation protein 1myogenic differentiation 1BTG1 interacts with MYOD1 (CMD1). This interaction was modeled on a demonstrated interaction between human BTG1 and chicken CMD1.-Pubmed
HPRDcalmodulin 1myogenic differentiation 1--Pubmed
HPRDcalmodulin 1myogenic differentiation 1--Pubmed
HPRDcalmodulin 2myogenic differentiation 1--Pubmed
HPRDcalmodulin 2myogenic differentiation 1--Pubmed
HPRDcalmodulin 3myogenic differentiation 1--Pubmed
HPRDcalmodulin 3myogenic differentiation 1--Pubmed
HPRDCell division cycle 34myogenic differentiation 1--Pubmed
HPRDubiquitin-conjugating enzyme Cdc34Myogenic differentiation antigen 1--Pubmed
HPRDCyclin dependent kinase 4myogenic differentiation 1--Pubmed

Recent Publications on MYOD1:

Pubmed Logo
In vitro myogenic differentiation of human bone marrow-derived mesenchymal stem cells as a potential treatment for urethral sphincter muscle repair.
To explore a new treatment strategy for urinary incontinence, human bone...
24th October, 2009
Department of Medicine II, Eberhard-Karls-University of Tubingen, Ann N Y Acad Sci. 2009 Sep;1176:135-43.
DOI Direct Link
Angiomatoid fibrous histiocytoma in a six-year-old child.
We report a case of AFH presenting as an asymptomatic subcutaneous nodule...
21st October, 2009
Northeastern Ohio Universities College of Medicine, Rootstown, OH, USA. Pediatr Dermatol. 2009 Sep-Oct;26(5):636-8.
DOI Direct Link
Investigation of LDHA and COPB1 as candidate genes for muscle development in the MYOD1 region of pig chromosome 2.
Porcine MYOD1 gene has been mapped to swine chromosome (SSC) 2p14-p17,...
16th October, 2009
Lab of Molecular Biology and Animal Breeding, Key Laboratory of Mol Biol Rep. 2009 Oct 16.
DOI Direct Link
Essential Amino Acids Increase MicroRNA-499, -208b, and -23a and Downregulate Myostatin and Myocyte Enhancer Factor 2C mRNA Expression in Human Skeletal Muscle.
Essential amino acids (EAA) stimulate muscle protein synthesis in humans....
16th October, 2009
Departments of Physical Therapy, University of Texas Medical Branch, J Nutr. 2009 Oct 14.
DOI Direct Link
Expression of caspase family and muscle- and apoptosis-specific genes during skeletal myogenesis in mouse embryo.
The caspases (Casps) are a family of cysteine proteases that are known to...
6th October, 2009
Department of Biomedical Sciences, Graduate School of Veterinary Medicine, J Vet Med Sci. 2009 Sep;71(9):1161-8.

View more research publications.

Patents:

Patents logo
US Patent No.Title
6608108 Method for treatment of tumors using nordihydroguaiaretic acid derivatives
6949379 Aptamer-mediated regulation of gene expression
6958411 Nordihydroguaiartic derivatives for use in treatment of tumors
6967102 Nitric oxide manipulation of muscle satellite cell activation
6995258 Nucleolar targeting of therapeutics against HIV

View more patents.

MYOD1 results (if any) from reagent suppliers

Google CSE Logo
MyoD1 antibody [5.2F], prediluted (ab7272) | Abcam
Mouse monoclonal [5.2F] to MyoD1, prediluted. MyoD1 belongs to the basic helix- loop-helix family of transcription factors and the myogenic factors subfamily
...
http://www.abcam.com/MyoD1-antibody-5-2F-prediluted-ab7272.h...

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Monoclonal Anti-MYOD1 antibody produced in mouse (M6190) - Datasheet
Monoclonal Anti-MyoD1 recognizes human, rat, chicken and mouse phosphoprotein ( 45 kDa), ... MyoD1 is not detected in normal adult tissues, but is ...
http://www.sigmaaldrich.com/etc/medialib/docs/Sigma/Datashee...

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The Abcam catalog
MyoD1 antibodies. ... MyoD1 antibody [5.2F]. IHC-P, IP, WB, ELISA, EM, ICC/IF, IHC-Fr ... MyoD1 antibody [5.2F] - BSA and Azide free. IP, EM, ICC/IF ...
http://www.abcam.com/index.html?t=7881&pt=1&c=2102...

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Monoclonal Mouse Antibody to MyoD1
BALB/C mice were injected with a recombinant mouse MyoD1 protein ... This antibody is specific to a 45 kD protein, which is identified as MyoD1. ...
http://dbiosys.com/_includes/documents/datasheets/DS-MOB278-...

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Myogenin D1. Mouse Monoclonal Antibody 5.2F , Human, Mouse, Rat ...
24 Mar 2008 ... terminus of mouse MyoD1 protein. It does not cross react with ... Monoclonal antibodies to the myogenic regulatory protein MyoD1: epitope ...
http://www.exalpha.com/pdfs/X1414M.pdf...

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Monoclonal Mouse Antibody to MyoD1
IVD Data Sheet. DS-Mob295-1-A. 08/05/2009. IVD: For In Vitro Diagnostic Use. DBS will not be held responsible for patent infringement or other violation ...
http://dbiosys.com/_includes/documents/datasheets/DS-MOB295-...

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MyoD (4H207) Antibody sc-71629
Human, MYOD1, 4654, 11p15.1, NM_002478 · P15172 · 159970. Mouse, Myod1, 17927, 7 B4, P10085 ... MyoD (1-318), sc-4080, 50 µg ...
http://www.scbt.com/datasheet-71629-myod-4h207-antibody.html...

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