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NAB2


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Symbol:NAB2
Name(s):NGFI-A binding protein 2 (EGR1 binding protein 2)
Type:protein-coding
Organism:Homo sapiens
Synonyms:MADER, MGC75085
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
16260776 Egr-1 induces the expression of its corepressor nab2 by activation of the nab2 promoter in a negative feedback loop
12427750 inhibits vascular endothelial growth factor-mediated gene induction and angiogenic responses of endothelial cells.
12030330 mutations in the human NAB2 gene are most likely not involved in the pathogenesis of peripheral neuropathies.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDEarly growth response protein 1NGFI-A binding protein 2--Pubmed
HPRDearly growth response 1NGFIA binding protein 2--Pubmed

Recent Publications on NAB2:

Pubmed Logo
Purification of Nuclear poly(A)-binding protein Nab2 reveals association with the yeast transcriptome and a messenger ribonucleoprotein (mRNP) core structure.
Nascent mRNAs produced by transcription in the nucleus are subsequently...
21st October, 2009
Biochemie Zentrum Heidelberg, Germany; J Biol Chem. 2009 Oct 19.
DOI Direct Link
Induction of early growth response-1 mediates microglia activation in vitro but is dispensable in vivo.
We have previously identified activation of microglia and induction of the...
6th October, 2009
Institute of Human Genetics, University of Regensburg, Neuromolecular Med. 2009;11(2):87-96. Epub 2009 Apr 14.
DOI Direct Link
Early growth response-1 is involved in foam cell formation and is upregulated by the TLR9-MyD88-ERK1/2 pathway.
Early growth response-1 (Egr-1), a zinc finger transcription factor, plays...
10th September, 2009
Aging-Associated Vascular Disease Research Center, Department of Biochem Biophys Res Commun. 2009 Dec 11;390(2):196-200. Epub 2009 Sep 6.
DOI Direct Link
Regulation of Lhb and Egr1 Gene Expression by GNRH Pulses in Rat Pituitaries Is Both c-Jun N-Terminal Kinase (JNK)- and Extracellular Signal-Regulated Kinase (ERK)-Dependent.
Pulsatile GNRH regulates the gonadotropin subunit genes in a differential...
28th August, 2009
Biol Reprod. 2009 Aug 26.
DOI Direct Link
Epidermal-growth-factor-induced proliferation of astrocytes requires Egr transcription factors.
Stimulation of astrocytes with epidermal growth factor (EGF) induced...
27th August, 2009
Department of Medical Biochemistry and Molecular Biology, University of J Cell Sci. 2009 Sep 15;122(Pt 18):3340-50. Epub 2009 Aug 25.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
7598052 Expression profile of thyroid cancer
7208313 Combined growth factor-deleted and thymidine kinase-deleted vaccinia virus vector
7186513 Methods for monitoring multiple gene expression
6969704 Methods for suppressing early growth response--1protein (Egr-1) to reduce vascular injury in a subject
6913882 Methods of screening for B cell activity modulators

View more patents.

NAB2 results (if any) from reagent suppliers

Google CSE Logo
Nab2 antibody [cl.1C4] (ab11987) | Abcam
Mouse monoclonal [cl.1C4] to Nab2. Nab2 acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2.
http://www.abcam.com/Nab2-antibody-cl-1C4-ab11987.html...

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NAB Antibody / NAB Antibodies
NAB2 (A-15) Antibody, sc-12151, goat IgG, N-terminus (h), WB, IP, IF, ELISA, human ... NAB2 (D-7) Antibody, sc-48416, mouse IgG2a, 346-525 (h), WB, IP, IF,
...
http://www.scbt.com/table-nab.html...

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Antibody Products - IgG Monoclonal Antibodies - GenWay
20-272-190692, Nab2 [cl.1C4] Related Product Names: - Nab2; 4665; NAB2; 602381; ... Mouse monoclonal [cl.1C4] to Nab2; 4665; NAB2; 602381; Q15742; MADER;; ...
http://www.genwaybio.com/all_monoclonal_antibodies.php?fl=N...

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NAB2 (h): 293T Lysate sc-117107
NAB2 (H-180): sc-22815. Western blot analysis of NAB2 expression in non- transfected: sc-117752 (A) and human NAB2 transfected: sc-117107 (B) 293T whole
cell ...
http://www.scbt.com/datasheet-117107-nab2-h-293t-lysate.html...

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Antibody Products - IgG Polyclonal Antibodies - GenWay
18-003-43240, NAB2 (NGFI-A binding protein 2 (EGR1 binding protein 2)) ... NAB2; MADER - EGR-1-binding protein 2; Melanoma-associated delayed early response ...
http://www.genwaybio.com/all_polyclonal_antibodies.php?fl=N...

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NAB2 (C-6) Antibody sc-28323
NAB2 (C-6): sc-28323 antibody 및 NAB2 (C-6) antibody conjugates를 사용한 논문 들을 ... Western blot analysis of NAB2 expression in K-562 whole cell lysate.
...
http://www.scbt.com/ko/datasheet-28323-nab2-c-6-antibody.htm...

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Abgent - Cancer Antibodies - Cancer
AT2968aNEW, N4BP2 monoclonal antibody (M01), ELISA,S-ELISA,WB-Re, H. AP7635cNEW, NAB2 Antibody (Center), WB, E, H. AT2973aNEW, NAT2 monoclonal antibody (M01 ...
http://www.abgent.com/products/category/cell_function/cancer...

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