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ATF3


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Symbol:ATF3
Name(s):activating transcription factor 3
Type:protein-coding
Organism:Homo sapiens
Synonyms:-
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18235102 ATF3 plays a protective role in renal ischemia-reperfusion injury and the mechanism of the protection may involve suppression of p53 and induction of p21
17599613 Coxsackievirus B3 (CVB3) infection markedly reduced ATF3 expression at mRNA and protein levels in parallel with p53 degradation, and preservation of p53 expression rescued CVB3 infection-induced ATF3 downregulation.
18001166 17-alpha ethinyl estradiol upregulates ATF3 expression in human foreskin fibroblasts in vitro.
16912181 Transcription factor Wilms' tumor 1 and ATF3 Transcription Factor are activated in Wilms' tumor and accelerate tumorigenesis.
16306208 ATF3 is up-regulated in the penile skin tissues of boys with hypospadias, which suggests a role for this transcription factor in the development of this abnormality.
12372430 human ATF3 gene is one of the target genes directly activated by p53
12833146 ATF-2 and ATF3 seem to play an important role in the protective response of human cells to ionizing radiation
12392999 ATF3 may function as a cytoprotective transcription factor in DOX-treated cardiac myocytes, at least in part, owing to downregulation of p53
16079301 this is a novel first report demonstrating that the expression of ATF3 occurs via early growth response gene-1 downstream of extracellular signal-regulated kinase1/2
12386811 induction of ATF3 protein, a member of the ATF/CREB family of transcription factors, by ionizing radiation requires normal cellular p53 function

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDActivating transcription factor 3jun D proto-oncogene--Pubmed
HPRDactivating transcription factor 3 isoform 1NFKB1--Pubmed
HPRDactivating transcription factor 3 isoform 1JUN-D--Pubmed
HPRDactivating transcription factor 3 isoform 1tumor protein p53--Pubmed
HPRDactivating transcription factor 3 isoform 1tumor protein p53--Pubmed
BINDactivating transcription factor 3 isoform 1tumor protein p53An unspecified isoform of ATF3 interacts with p53.-Pubmed
HPRDactivating transcription factor 3 isoform 1activating transcription factor 3 isoform 1--Pubmed
BINDactivating transcription factor 3 isoform 1activating transcription factor 3 isoform 1An unspecified isoform of ATF3 interacts with itself intermolecularly. This interaction was modeled on a demonstrated interaction between ATF3 from an unspecified species.-Pubmed
HPRDactivating transcription factor 3 isoform 1jun oncogene--Pubmed
HPRDactivating transcription factor 3 isoform 1jun oncogene--Pubmed

Recent Publications on ATF3:

Pubmed Logo
Expression of stress-response ATF3 is mediated by Nrf2 in astrocytes.
Activating Transcription Factor 3 (ATF3), a member of the ATF/CREB family,...
30th October, 2009
NeuroVascular Coordination Research Center, College of Pharmacy and Nucleic Acids Res. 2009 Oct 28.
DOI Direct Link
Nuclear calcium signaling controls expression of a large gene pool: identification of a gene program for acquired neuroprotection induced by synaptic activity.
Synaptic activity can boost neuroprotection through a mechanism that...
29th October, 2009
Department of Neurobiology, Interdisciplinary Center for Neurosciences PLoS Genet. 2009 Aug;5(8):e1000604. Epub 2009 Aug 14.
DOI Direct Link
Age-associated changes in cardiac gene expression after preconditioning.
BACKGROUND: Cardiac protection afforded by ischemic preconditioning (IPC)...
28th October, 2009
Department of Anesthesiology, Stony Brook University School of Medicine, Anesthesiology. 2009 Nov;111(5):1052-64.
DOI Direct Link
Peripheral and central sensitization in remote spinal cord regions contribute to central neuropathic pain after spinal cord injury.
Central neuropathic pain (CNP) developing after spinal cord injury (SCI)...
27th October, 2009
Department of Neuroscience and Cell Biology, University of Texas Medical Pain. 2009 Oct 21.
DOI Direct Link
Identification of a novel amino acid response pathway triggering ATF2 phosphorylation in mammals.
It has been well established that amino acid availability can control gene...
14th October, 2009
Unite de Nutrition Humaine, UMR 1019, INRA de Theix, 63122 Saint Genes Mol Cell Biol. 2009 Oct 12.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
6936417 Gene expression in bladder tumors
7189506 DNA binding compound-mediated molecular switch system
7195870 Diagnosis of diseases associated with gene regulation
7195894 MKK7 activation inhibitor
7198951 Adeno-associated virus (AAV) serotype 9 sequences, vectors containing same, and uses therefor

View more patents.

ATF3 results (if any) from reagent suppliers

Google CSE Logo
ATF-3 (C-19) Antibody sc-188
See how others have used ATF-3 (C-19): sc-188 antibody and or ATF-3 (C-19) ... Western blot analysis of ATF-3 expression in RAW 264.7 whole cell lysate. ...
http://www.scbt.com/datasheet-188-atf-3-c-19-antibody.html...

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ATF3 antibody [44C3a] (ab58668) | Abcam
Mouse monoclonal [44C3a] to ATF3. Activating transcription factor 3 is a member of the mammalian activation transcription factor/cAMP responsive ...
http://www.abcam.com/ATF3-antibody-44C3a-ab58668.html...

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ATF3 antibody, Anti-ATF3 (RABBIT) Antibody, Rabbit N/A Antibody
Buy quality rabbit ATF3 antibody (interacts with human bovine mouse rat), ... Affinity Purified anti-ATF3 [Rabbit]; Activating transcription factor 3; ...
http://www.genwaybio.com/product_info.php?products_id=292437...

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ATF-3 (H-90) Antibody sc-22798
See how others have used ATF-3 (H-90): sc-22798 antibody and or ATF-3 (H-90) ... Western blot analysis of ATF-3 expression in RAW 264.7 (A) and PMA treated ...
http://www.scbt.com/datasheet-22798-atf-3-h-90-antibody.html...

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ATF3 antibodies: Cancer > Tumor biomarkers > Other | Abcam
ATF3 antibodies. ... ATF3 antibody. WB, ELISA. Images. Rabbit polyclonal. Reacts with: Hu, Ms, Rat. ab58668 · ATF3 antibody [44C3a]. WB, Dot ...
http://www.abcam.com/index.html?t=136321&pt=1&c=4375&ei=&mu=...

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ATF-3 (C-19) Antibody sc-188
ATF-3 (C-19): sc-188 antibody 및 ATF-3 (C-19) antibody conjugates를 사용한 ... Western blot analysis of ATF-3 expression in RAW 264.7 whole cell lysate. ...
http://www.scbt.com/ko/datasheet-188-atf-3-c-19-antibody.htm...

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Product Specification Sheet
recombinant ATF3 present in transfected mammalian or E.coli whole cell extracts. ... transfected with HA epitope tagged human ATF3. ROCKLAND's ...
http://www.rockland-inc.com/objects/catalog/product/extras/1...

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