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NBN

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Symbol:	NBN
Name(s):	nibrin
Type:	protein-coding
Organism:	Homo sapiens
Synonyms:	AT-V1, AT-V2, ATV, FLJ10155, MGC87362, NBS, NBS1
Links:	Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications
Publication Link	Summary of findings
18270339	Observational study and meta-analysis of gene-disease association. (HuGE Navigator)
18280732	Observational study of gene-disease association. (HuGE Navigator)
18003706	NBS1 mediates ATR-dependent RPA hyperphosphorylation following replication fork stall and collapse.
18025084	Rapid accumulation of MRE11 and NBS1 at sites of DNA damage requires PARP1.
16152606	Observational study of genotype prevalence and gene-disease association. (HuGE Navigator)
16195237	Observational study of gene-disease association. (HuGE Navigator)
16214912	Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
16343742	Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
16638864	Observational study of gene-disease association. (HuGE Navigator)
16702373	Observational study of gene-disease association. (HuGE Navigator)
→View more information from publications.

Interacting gene products
Interaction Type	Gene 1	Gene 2	Interaction description	Complex	Publication Link
BIND	ataxia telangiectasia mutated protein isoform 1	nibrin isoform 1	NBS1 interacts with ATM.	-	Pubmed
BIND	ataxia telangiectasia and Rad3 related protein	nibrin isoform 1	NBS1 interacts with ATR.	-	Pubmed
HPRD	BRCA1	nibrin	-	-	Pubmed
HPRD	breast cancer 1, early onset isoform 1	Nibrin	-	-	Pubmed
HPRD	cyclin-dependent kinase 9	nibrin	-	-	Pubmed
BIND	activating transcription factor 2	nibrin isoform 1	ATF2 interacts with Nbs1.	-	Pubmed
HPRD	H2AX histone	nibrin	-	-	Pubmed
HPRD	H2A histone family, member X	Nibrin	-	-	Pubmed
HPRD	Double strand break repair protein MRE11A	nibrin	-	-	Pubmed
BIND	-	nibrin isoform 1	NBS1 interacts with MRE11A (Mre11).	-	Pubmed

Recent Publications on NBN:
A supramodular FHA/BRCT-repeat architecture mediates Nbs1 adaptor function in response to DNA damage. The Mre11/Rad50/Nbs1 protein complex plays central enzymatic and signaling...	29th October, 2009	Division of Molecular Structure, Medical Research Council National	Cell. 2009 Oct 2;139(1):100-11. DOI Direct Link
Nbs1 flexibly tethers Ctp1 and Mre11-Rad50 to coordinate DNA double-strand break processing and repair. The Nijmegen breakage syndrome 1 (Nbs1) subunit of the Mre11-Rad50-Nbs1...	29th October, 2009	Department of Molecular Biology, The Scripps Research Institute, 10550	Cell. 2009 Oct 2;139(1):87-99. DOI Direct Link
DNA ligase I and Nbs1 proteins associate in a complex and colocalize at replication factories. DNA ligase I is the main DNA ligase activity involved in eukaryotic DNA...	29th October, 2009	Istituto di Genetica Molecolare, Consiglio Nazionale delle Ricerche,	Cell Cycle. 2009 Aug 15;8(16):2600-7. Epub 2009 Aug 24.
Clinical variability and expression of the NBN c.657del5 allele in Nijmegen Breakage Syndrome. Patients affected by the autosomal recessive Nijmegen Breakage Syndrome...	24th October, 2009	Institut fur Humangenetik, Charite - Universitatsmedizin Berlin, Campus	Gene. 2009 Nov 1;447(1):12-7. Epub 2009 Jul 25. DOI Direct Link
A superconducting NbN detector for neutral nanoparticles. We present a proof-of-principle study of superconducting single photon...	14th October, 2009	University of Vienna, Boltzmanngasse 5, A-1090 Vienna, Austria.	Nanotechnology. 2009 Nov 11;20(45):455501. Epub 2009 Oct 13. DOI Direct Link
→View more research publications.

Clinical Trials:
A Study of Belimumab in Subjects With Systemic Lupus Erythematosus (SLE)

Patents:
US Patent No.	Title
7545685	High voltage switch circuit having boosting circuit and flash memory device including the same
7561920	Electric and acoustic stimulation fitting systems and methods
7563715	Method of producing thin films
7563893	3-Phenyl-cinnoline analogue and antitumor agent using the same
7564136	Integration scheme for Cu/low-k interconnects
→View more patents.

NBN results (if any) from reagent suppliers

NBS1 antibody, NBS1 [1D7] Antibody, Mouse Monoclonal Antibody NBN also functions in telomere length maintenance by generating the 3' ... NBN is a major player in the control of intra-S-phase checkpoint and there is ... http://www.genwaybio.com/product_info.php?products_id=193314...
Nibrin Monoclonal Antibody Immunohistochemistry staining of NBN in kidney (formalin- fixed paraffin- embedded) using NBN antibody. BUFFER: Antibody is supplied in PBS. ... http://www.prosci-inc.com/shop/pdf/48-852.pdf...
Antibodies to DNA Repair Proteins human ... NBN(4683), human, ARR, ICC, IP, WB, pricing. R2402, Monoclonal Anti- RAD1 DNA Repair Protein antibody produced in mouse, 33 (monoclonal) ... http://www.sigmaaldrich.com/etc/controller/controller-page.h...
ATM antibody, ATM [3E8] Antibody, Mouse Monoclonal Antibody Part of the BRCA1-associated genome surveillance complex (BASC), which contains BRCA1, MSH2, MSH6, MLH1, ATM, BLM, PMS2 and the RAD50-MRE11-NBN protein ... http://www.genwaybio.com/product_info.php?products_id=193220...
Nibrin (C-19) Antibody sc-8580 Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, NBN, 4683, 8q21.3, NM_001024688, ... http://www.scbt.com/datasheet-8580-nibrin-c-19-antibody.html...
Antibodies to Transcription Regulators NBN(4683) rat ... Nbn(85482), rat, human, canine, chimpanzee, ARR, IF (i), IP, WB, pricing ..... human ... NBN(4683), human, ARR, ICC, IP, WB, pricing ... http://www.sigmaaldrich.com/etc/controller/controller-page.h...
Abgent - Cancer Antibodies - Cancer AT2976aNEW, NBN monoclonal antibody (M01), ELISA,S-ELISA,WB-Ce,WB-Re, H. AT2977a NEW, NBR1 monoclonal antibody (M01), ELISA,S-ELISA,WB-Ce,WB-Re, H ... http://www.abgent.com/products/category/cell_function/cancer...

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NBN

Gene Information from Publications

Interacting gene products

Recent Publications on NBN:

Clinical Trials:

Patents:

NBN results (if any) from reagent suppliers