Gene Information from Publications |
| Publication Link |
Summary of findings |
| 17928013 |
In a cohort of 70 GC samples, low level of phosphorylated ATM was significantly correlated with poor differentiation, lymph node metastasis and poor 5-year survival (P<0.05). |
| 18264724 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18270339 |
Observational study and meta-analysis of gene-disease association. (HuGE Navigator) |
| 17910737 |
Large genomic mutations within the ATM gene by MLPA, including a duplication of 41 kb from exon 4to 20 afre reported. |
| 18164969 |
ATM variants were detected in about 14% of the lung cancer patients and did not differ significantly from the control subjects. |
| 17932249 |
reconstitution of ATM kinase activity decreases FLIP protein levels and restores Fas sensitivity in Hodgkin lymphoma-derived cells |
| 11165203 |
Observational study of gene-disease association. (HuGE Navigator) |
| 11606401 |
Observational study of genotype prevalence and gene-disease association. (HuGE Navigator) |
| 11849780 |
Observational study of gene-disease association. (HuGE Navigator) |
| 11996792 |
Observational study of gene-disease association. (HuGE Navigator) |
| 12036913 |
Observational study of gene-disease association. (HuGE Navigator) |
| 12473176 |
Observational study of gene-disease association. (HuGE Navigator) |
| 12473594 |
Observational study of gene-disease association. (HuGE Navigator) |
| 12917204 |
Observational study of genotype prevalence and gene-disease association. (HuGE Navigator) |
| 12935922 |
Observational study of gene-disease association. (HuGE Navigator) |
| 14562025 |
Observational study of gene-disease association. (HuGE Navigator) |
| 14643952 |
Observational study of genotype prevalence. (HuGE Navigator) |
| 14735203 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15042666 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15084244 |
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 15164409 |
Observational study of genotype prevalence. (HuGE Navigator) |
| 15217510 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15280931 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15450731 |
Observational study of gene-environment interaction. (HuGE Navigator) |
| 15629612 |
Observational study of gene-disease association and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 15824150 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15878096 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15880680 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15987456 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16014569 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16049814 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16167060 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16338099 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16497724 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16520463 |
Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator) |
| 16574953 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16622469 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16638864 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16652348 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16765197 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16832357 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16914028 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16958054 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 16966185 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17132159 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17151932 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17164260 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 17203191 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17293864 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17333338 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17341484 |
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) |
| 17351744 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17393301 |
Observational study of genotype prevalence, gene-disease association, and gene-environment interaction. (HuGE Navigator) |
| 17409195 |
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) |
| 17428320 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 17428325 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17431766 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17502119 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17517479 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 17582598 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 17623063 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 17640065 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18164969 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18171990 |
Sp1 is a novel ATM substrate that plays a role in the cellular response to DNA damage |
| 17706468 |
ATM is primarily localized to the nucleus in cerebellar Purkinje neurons in postmortem human brain tissue samples, although some light cytoplasmic ATM staining was also observed. |
| 18172300 |
Taken together, these results show a DNA-PK-dependent component to the IR-induced G(2) checkpoint, in addition to the well-defined ATM-dependent component. |
| 17942393 |
a novel role for ATM that selectively stimulates KAP1 Ser-824 phosphorylation to repress its sumoylation, leading to the de-repression of expression of a subset of genes involved in promoting cell cycle control and apoptosis |
| 17640065 |
common variants of ATM do not significantly contribute to the risk of non-Hodgkin lymphoma in the general population. However, some rare, functionally deleterious variants may contribute to an increased risk of development of rare subtypes of the disease |
| 17632790 |
study presents two siblings with clinically mild taxia-telangiectasia (A-T) despite homozygosity for a truncating ATM mutation that leads to complete ATM deficiency, severe cellular phenotype, and cerebellar atrophy typical of classical A-T |
| 17431766 |
Study reveals no apparent association of common ATM variants with breast cancer risk. |
| 17606465 |
evidence for an intrinsic mitochondrial dysfunction in ataxia telangiectasia cells, and implicate a requirement for ATM in the regulation of mitochondrial function |
| 17923702 |
These results are consistent with a model in which acetylation of lysine 3016 in the FATC domain of ATM activates the kinase activity of ATM. |
| 17510082 |
aspirin-induced G1 arrest in colon cancer cells was dependent on ataxia-telangiectasia-mutated kinase (ATM). |
| 17694070 |
MRN is required for TRF1 phosphorylation by ATM and that such phosphorylation results in the release of TRF1 from telomeres, promoting telomerase access to the ends of telomeres |
| 17582598 |
risk-conferring variants might act through down-regulating the functions of ATM in DNA repair activity upon genetic insults such as ionizing radiation |
| 16951182 |
ATR/ATM-independent checkpoint response to DNA synthesis inhibition exists in HeLa cells. |
| 17517479 |
Sequence variants located in the ATM gene, in particular the 5557 G-->A polymorphism, may predict for late adverse radiation responses in breast cancer patients. |
| 17855027 |
Lead contamination generates late unrepairable double strand breaks that impact upon the ATM-dependent stress signaling pathway by favoring propagation of errors. |
| 17786248 |
mitochondrial homeostasis contributes to the complex pathology of Ataxia-telangiectasia and that ribonucleotide reductase genes are candidate disease loci in mitochondrial DNA-depletion syndromes |
| 17609267 |
ATM-dependent Sp1 phosphorylation appears to be a global response to various DNA damage stress including viral DNA replication. |
| 17384674 |
-terminal domains of NBS1 are the major regulatory domains for recombination pathways, very likely through the recruitment and retention of double strand breakage sites in an ATM-independent fashion. |
| 17384681 |
Alterations in the cellular levels of TIP influence the phosphorylation state of a specific protein substrate of ataxia-telangiectasia mutated (ATM)/ATM- and Rad3-related (ATR) kinases. |
| 17611684 |
zoledronate induces DNA damage and S phase arrest, accompanied by activation of the ATM/Chk1/cdc25 pathway in a human osteosarcoma cell line |
| 17478428 |
Results suggest that protein ubiquitylation is an important regulatory mechanism downstream of ATM (ataxia telangiectasia-mutated) and ATR (ATM-Rad3-related) activation for checkpoint control. |
| 17613764 |
interphase Fish on samples from 30 MCL patients revealed 11 deletions of ATM |
| 17537652 |
review of the role of ATM as a mediator of responses to DNA double strand breaks and the possible effects of activators and inhibitors of ATM |
| 17525732 |
in ATMIN-deficient cells, basal ATM activity and ATM activation by hypotonic stress and inhibition of DNA replication was impaired |
| 17593081 |
No evidence was found that reduction in ATM protein levels in breast carcinoma is the result of epigenetic silencing. Cross-regulation between DNA-PKcs and ATM may be a possible cause in a subset of tumours. |
| 17634426 |
This is the first report of high ATM-Chk2 kinase activation and its linkage to replication defects in a Bloom syndrome model. |
| 16319535 |
ATM is activated by default at each mitotic onset and phosphorylates p53 at Ser15 so as to keep it inactive at centrosomes when the spindle is correctly in place |
| 15456759 |
PTIP facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation |
| 15173573 |
signaling via ATM is necessary for full activation of TonEBP/OREBP |
| 16497931 |
results show that ATM phosphorylates Ser85 of NEMO in response to genotoxic stress & that this is required for ubiquitination of NEMO; this modification is essential for nuclear export of NEMO & ATM & their interaction with IKK in the cytoplasm |
| 12969974 |
rare polymorphic variants of the ATM gene identified in children with Hodgkin disease encode functionally abnormal proteins |
| 17409144 |
EBNA3C can directly regulate the G2/M component of the host cell cycle machinery through ATM/ATR and Chk2, allowing for the release of the checkpoint block |
| 11897822 |
ATM mutations in Finnish breast cancer patients. |
| 12429935 |
ATM kinase is not required for signaling when chromatid decatenation is blocked |
| 12645530 |
ATM is activated by ATP in a mechanism involving autophosphorylation |
| 15389585 |
DNA-PK, ATM and possibly other kinases implicated in H2AX phosphorylation. |
| 17242184 |
ATM regulates G(2)/M checkpoint recovery through inhibitory phosphorylations of Artemis that occur soon after DNA damage, thus setting a molecular switch that, hours later upon completion of DNA repair, allows activation of the Cdk1-cyclin B complex. |
| 17486112 |
Ordered chromatin structure changes that occur after DNA breakage depend on functional NBS1 and ATM, and facilitate DNA DSB repair. |
| 12958068 |
the greater severity of TP53-mutant B-CLLs compared with ATM-mutant B-CLLs is consistent with the additive effect of defective apoptotic and elevated survival responses after DNA damage in these tumors |
| 16012708 |
The pattern of ATM expression was changed from normal mucosa to tumour and less expression of ATM may be related to males. |
| 16728507 |
PI3K-IA activity is necessary for both high NaCl- and ionizing radiation-induced activation of ATM and (ii) high NaCl activates PI3K-IA, which, in turn, contributes to full activation of TonEBP/OREBP via ATM. |
| 14966265 |
Data describe a novel pathway of ataxia telangiectasia mutated (ATM) and DNA-dependent protein kinase (DNA-PK) signaling that results in nuclear factor kappaB (NF-kappaB) activation and chemoresistance in response to DNA damage. |
| 17227291 |
The levels of CAA and CHP in lymphocytes were increased many-fold during their stimulation. |
| 15485651 |
IGF-1 induces AMPK-alpha subunit phosphorylation via an ATM-dependent and LKB1-independent pathway |
| 16266405 |
ATM gene founder haplotypes and associated mutations are found in ataxia-telangiectasia |
| 16941484 |
ATM mutations in Italian families with ataxia telangiectasia include two distinct large genomic deletions. |
| 17341604 |
ATM may be essential for Ku activation to repair DNA damage from oxidative stress and prevent cell death caused by oxidative stress. |
| 12833146 |
ATM is involved in a signaling pathway that induces ATF3 after ionizing radiation |
| 15539948 |
Thus, optimal repair of damaged replication fork lesions likely requires both ATR and ATM. BLM recruits 53BP1 to these lesions independent of its helicase activity, and optimal activation of ATM requires both p53 and BLM helicase activities. |
| 15923642 |
These results suggest that hMOF influences the function of ATM. |
| 16432227 |
Myc overexpression causes DNA damage in vivo and the ATM-dependent response to this damage is critical for p53 activation, apoptosis, and the suppression of tumor development |
| 16636671 |
activation of ATM suppresses Bcl-2-induced tumorigenesis, and that attenuation of ATM function may be an important event in breast cancer progression |
| 15459181 |
results implicate ATM in the HRR-mediated rescue of replication forks impaired by thymidine treatment |
| 17151932 |
study found associations of risk haplotypes and protective haplotypes in p53 for glioblastoma and in ATM for meningioma; study provides new data that could add to our understanding of brain tumour susceptibility |
| 12612651 |
Review. DNA double-strand breaks activate ATM. ATM modulates many signalling pathways. ATM mutations cause the cancer-prone disorder ataxia-telangiectasia. Understanding ATM's action clarifies the relation of defective responses to DNA damage & cancer. |
| 17389389 |
Antisense oligonucleotides corrected prototypic ATM splicing mutations and aberrant ATM function. |
| 15516988 |
epigenetic silencing of ATM expression occurs in locally advanced breast tumors, and establish a link at the molecular level between reduced ATM function and sporadic breast malignancy |
| 15226443 |
Data show that DNA damage induces the accumulation of hPMS1, hPMS2, and hMLH1 through ataxia-telangiectasia-mutated (ATM)-mediated protein stabilization. |
| 12660173 |
targets tousled like kinasese via DNA damage checkpoint |
| 14744854 |
ATM plays a critical role in regulating homologous recombination repair but not nonhomologous end joining throughout the cell cycle |
| 16832357 |
ATM mutations that cause ataxia-telangiectasia in biallelic carriers are breast cancer susceptibility alleles in monoallelic carriers, with an estimated relative risk of 2.37 |
| 17428792 |
physical interaction between the major DSB signaling kinase, ATM and poly(ADP-ribosyl)ation by PARP-1, a key enzyme of chromatin remodeling. |
| 11927575 |
lack of role in cellular response to DNA strand-scission enediyne C-1027 |
| 12861053 |
multiple functional domains of NBS1 are required for ATM-dependent activation of CHK2, nuclear focus formation, S phase checkpoint control, and cell survival after exposure to ionizing radiation |
| 15964794 |
ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1. |
| 16082221 |
ATM directly activates p53 while activating a safe-lock mechanism to inactivate the negative regulators of p53, Mdm2, and Mdmx [review] |
| 12650908 |
In conclusion, effective and prompt IR-induced Rad51 focus formation is cell cycle-regulated and requires both ATM and c-Abl. |
| 12935922 |
Total missense mutations were significantly elevated in cases of breast neoplasms. |
| 14754616 |
ATM was found to have a minor contribution to the pathogenesis of some B-cell chronic lymphocytic leukemia patients. |
| 15039971 |
Five haplotypes account for fifty-five percent of ATM mutations in Brazilian patients with ataxia telangiectasia |
| 15101044 |
Alterations in the ATM gene are associated with increased chromosome radiosensitivity. |
| 15280449 |
ATM is not required for dephosphorylation and inhibition of Polo-like kinase 1 activity following mitotic DNA damage. |
| 15790808 |
findings show that the Mre11-Rad50-Nbs1 (MRN) complex acts as a double-strand break sensor for ATM and recruits ATM to broken DNA molecules |
| 15837784 |
Down-regulation of ATM protein sensitizes human prostate cancer cells to radiation-induced apoptosis |
| 11859564 |
ATM: from phenotype to functional genomics--and back |
| 15546858 |
ATM is specifically activated by IR-induced DSBs, with little or no contribution from SSBs and other types of DNA damage |
| 15546863 |
PKB/Akt activation in response to insulin or ionizing radiation is mediated through ATM |
| 15788536 |
sites important for Hdm2-mediated ubiquitination of Hdmx after double-strand break induction; one of these sites, S403, is a direct ATM target |
| 16327781 |
we show that efficient ATM-dependent ATR activation in response to DSBs is restricted to the S and G2 cell cycle phases and requires CDK kinase activity. Thus, in response to DSBs, ATR activation is regulated by ATM in a cell-cycle dependent manner |
| 16431910 |
ATM and Mre11 may stimulate the ATR signaling pathway by converting DNA damage generated by ionizing radiation into structures that recruit and activate ATR |
| 14657032 |
Infection with an adenovirus lacking the E4 region also induces a cellular DNA damage response, with activation of ATM. |
| 16325375 |
Data provide evidence that ATM, a predominantly nuclear kinase, could be relocalized to the plasma membrane by CKIP-1. |
| 15024084 |
Results suggest that E2F1 plays a central role in signaling disturbances in the retinoblastoma growth control pathway and, by upregulation of Chk2 by Atm and Nbs1, may sensitize cells to undergo apoptosis. |
| 12032824 |
Aberrant methylation of the ATM promoter correlates with increased radiosensitivity in a human colorectal tumor cell line. |
| 12091354 |
ATM mutations are rare in familial chronic lymphocytic leukemia. |
| 15279774 |
DNA damage induceds activation of ATM [review] |
| 15279777 |
hSMG-1 teams with ATM and ATR to insure the overall quality of the transcriptome in human cells [review] |
| 15279780 |
53BP1 is an activator of ATM in response to DNA damage [review] |
| 15279808 |
analysis of the domain structure of the ATM molecule, sites of interaction with other proteins and the consequences of specific amino acid changes on function [review] |
| 12782595 |
ATM is involved in histone acetylation-mediated gene regulation. |
| 15174027 |
Adult-onset ataxia telangiectasia due to ATM 5762ins137 mutation homozygosity. |
| 11723136 |
In ataxia telangiectasia-mutated (ATM)-deficient cells the amount of nuclear PP2A heterotrimer relative to heterodimer was not We conclude a novel ATM-dependent mechanism is regulating association of B55 subunits with nuclear PP2A in response to IR |
| 14532133 |
ATM is activated and phosphorylates key players in various branches of the DNA damage response network. |
| 12915485 |
Polyglutamine-expanded proteins strongly activated ATM. |
| 15929992 |
the amino terminus of ATM is crucial not only for nuclear localization but also for chromatin association, thereby facilitating the kinase activity of ATM in vivo |
| 15928302 |
These results confirm a moderate risk of breast cancer in A-T heterozygotes and give some evidence of an excess risk of other cancers but provide no support for large mutation-specific differences in risk. |
| 16184611 |
This report demonstrates activation of ATM and ATM-mediated phoshorylation of H2AX, both in relation to cell-cycle phase and onset of apoptosis within the same cells. |
| 14983937 |
The presence of the ATM protein at the same or a higher level than that in normal prostate cells might have an important role in the maintenance of the shortened telomeres commonly found in prostate cancer cells. |
| 12810666 |
There is a significant prevalence of ATM mutations in breast and ovarian cancer families. This adds to a growing body of evidence that ATM mutations confer increased susceptibility to breast cancer. |
| 12882767 |
ATM missense variants could confer an AT-like phenotype and influence the formation of retinal and choroidal vascular abnormalities. |
| 16474133 |
results indicate that KSHV vIRF1 comprehensively compromises an ATM/p53-mediated DNA damage response checkpoint by targeting both upstream ATM kinase and downstream p53 tumor suppressor |
| 16474151 |
results indicate that ATM can positively influence HIV-1 Rev function |
| 16574953 |
Preeminent associations were identified in SNPs mapping to genes pivotal in the DNA damage-response and cell-cycle pathways, including ATM F858L and P1054R, CHEK2 I157T, BRCA2 N372H, and BUB1B Q349R. |
| 16997395 |
PINs are generally regarded as precursors of prostatic carcinoma. Our results suggest that ATM and Chk2 activation at earlier stages of prostate tumorigenesis suppresses tumor progression, with attenuation of ATM activation leading to cancer progression. |
| 17121863 |
a novel pathway, which is connected between ataxia telangiectasia-mutated kinase (ATM) and protein phosphatase-Plk1 in DNA damage response in mitosis |
| 12519769 |
ATM has a critical role in the response of hypoxia and reperfusion in solid tumors. |
| 12926986 |
ATM is involved in regulation of transcription factors such as SP1, AP1 and MTF1 |
| 12955071 |
we propose that ATM activation is not linked solely to DSBs and that ATM participates in initiating signaling pathways in response to replication block and UV-induced DNA damage |
| 14695167 |
In cells with mutant Nbs1, suppression of 53BP1 led to decreased ATM activation and phosphorylation of ATM substrates. |
| 14695186 |
Study suggests a general pattern of increased breast cencer risk associated with carrying any one of the ATM variants studied, with a significant association being observed in individuals carrying variants on both ATM alleles. |
| 14695534 |
Analysis of splicing mutations in the ATM gene. |
| 15073328 |
ATM-mediated phosphorylation of CREB in response to DNA damage modulates CREB-dependent gene expression and that dysregulation of the ATM-CREB pathway may contribute to neurodegeneration in ataxia telangiectasia |
| 12065055 |
Roles of DNA-dependent protein kinase and ATM in cell-cycle-dependent radiation sensitivity in human cells. |
| 12676583 |
ATM is the transducer of the S phase checkpoint and presumably propagates the signal through downstream effector kinases. |
| 15964848 |
host cells activate ATM checkpoint signaling in response to HSV infection |
| 16293623 |
ATM is required for CREB phosphorylation in UV irradiation-damaged cells. |
| 16426422 |
Frequency of activated ATM and phosphorylated H2AX molecules, per apoptotic cell, is comparable. |
| 16461339 |
ATM signals DNA double-strand breaks arising from ionizing radiation through a checkpoint kinase (Chk)2-dependent pathway. |
| 16582589 |
Myc and E2F1 engage the ATM signaling pathway to activate p53 and induce apoptosis [review] |
| 16628006 |
2-deoxy-D-glucose reduces the level of constitutive activation of ATM and phosphorylation of histone H2AX |
| 16914028 |
Results do not support association of the 5557G>A or ivs38-8T>C variant with increased breast cancer risk or with bilateral breast cancer. |
| 16931761 |
in response to DNA damage, ATM phosphorylated COP1 on Ser(387) and stimulated a rapid autodegradation mechanism; ionizing radiation triggered an ATM-dependent movement of COP1 from the nucleus to the cytoplasm |
| 17124492 |
ATM phosphorylation at Ser1981, a characterised autophosphorylation site, is ATR-dependent and ATM-independent following replication fork stalling or ultraviolet rays treatment. |
| 17178844 |
Function for ATM in the control of mitogenic pathways affecting cell signaling and emphasize the key role of ATM in coordinating the cellular response to DNA damage. |
| 17428325 |
common polymorphisms in the ATM, BRCA1, BRCA2, CHEK2 and TP53 cancer susceptibility genes are not shown to increase breast cancer risk |
| 17426037 |
a novel mechanism for activation of the activity of ATM kinase by retinoic acid , and implicate ATM in the regulation of CREB function during RA-induced differentiation. |
| 17594478 |
implicate ATM as the phosphoinositide 3-kinase related protein kinases that phosphorylates H2AX histone in response to DNA damage caused by cigarette smoke |
| 12673126 |
ataxia telangiectasia mutated (ATM) gene mutation/deletion is Associated with rhabdomyosarcoma |
| 12545170 |
our data suggest that ATM may mediate cell response to mitogenic factors by tightly regulating the set point of the CaR and thereby modulating the crosstalk between this metabotropic receptor and growth factor receptors |
| 15361830 |
Chk2 activity is triggered by a greater number of double strand breaks, implying that, below a certain threshold level of lesions, DNA repair can occur through ATM, without enforcing Chk2-dependent checkpoints. |
| 16141325 |
DNA damage induces the rapid acetylation of ATM, dependent on the Tip60 histone acetyltransferase; activation of Tip60 by DNA damage and the recruitment of the ATM-Tip60 complex to sites of DNA damage is independent of ATM's kinase activity. |
| 16380133 |
Two novel mutations in the ATM gene were identified in Chinese ataxia telangiectasia patient. The first one is a novel, homozygous, Gly449Ala mutation. The second one is a compound heterozygous mutation, which consists of a novel,(Gly204Stop)mutation. |
| 12628935 |
ATM functions upstream of protein kinase c-delta. |
| 11830600 |
role in breast cancer |
| 11830610 |
at least two ATM mutations are associated with a sufficiently high risk of breast cancer to be found in multiple-case breast cancer families; genetic susceptibility for breast cancer |
| 12034743 |
ATM and BLM function together in recognizing abnormal DNA structures by direct interaction and that these phosphorylation sites in BLM are important for radiosensitivity status but not for SCE frequency. |
| 15489221 |
hydroxyl radicals contribute to the doxorubicin-induced activation of ATM-dependent pathways |
| 15846060 |
Our results strongly support the physiological relevance of the recently proposed model of ATM autoactivation, and provide further evidence for constitutive activation of the DNA damage machinery during cancer development. |
| 14745549 |
ATM and NBS regulate several genes in common, both of these proteins also have distinct patterns of gene regulation. |
| 12362033 |
Subtle constitutional alterations of ATM may impart an increased risk of developing breast cancer and therefore act as a low penetrance, high prevalence gene in the general population. |
| 15510216 |
Autophosphorylation of ATM is regulated by protein phosphatase 2A. |
| 15533933 |
data reveal activated ATM and ATR exhibit selective substrate specificity in response to DNA damage |
| 12646636 |
ATM seems dispensable in the somatic hypermutation and Ig heavy chain variable-diversity- joining recombination processes but is clearly involved in the end joining-repair machinery in class switch recombination. |
| 15713674 |
a protein interaction domain in the N terminus of ATM is required for DNA damage-induced association of ATM with its target proteins |
| 12511424 |
A dominant-negative germline missense ATM mutation (8921C>T; Pro2974Leu), located in the PI-3-kinase domain was found in a childhood ALL patient with MLL rearrangement. Altered ATM function plays some pathogenic role in the development of MLL+ leukemia. |
| 15210935 |
ATM/ATR-dependent (ataxia-telangiectasia-mutated/ATM- and Rad3-related) checkpoint pathways are directly linked to three members of the MCM complex(MCM2,MCM3,MCM7). |
| 15390180 |
The risk of breast cancer is associated with the alteration of binding domains rather than with the length of the predicted ATM protein. |
| 15611093 |
ATM checkpoint signal transduction is elicited by Epstein-Barr virus lytic replication |
| 15880680 |
We identified three new breast cancer families with c.1066-6T>G, and seven families with c.4258C>T. |
| 15880721 |
Ataxia telangiectasia (A-T) patients from 16 Russian families were assessed for immunological status and ATM haplotype analysis, and screened for ATM mutations. |
| 15916964 |
Data demonstrate that the protein kinase ATM phosphorylates ATF2 on serines 490 and 498 following ionizing radiation (IR). |
| 16603769 |
FATC domain of ATM mediates the interaction between ATM and Tip60 |
| 16705183 |
The activation of ATM/ATR/CHK signaling pathways contributes to this G2 checkpoint and highlight the interrelated roles of p14ARF and the Tip60 protein in the initiation of this DNA damage-signaling cascade. |
| 16905549 |
Mre11 stabilizes Nbs1 and Rad50 and MRN activates Chk2 downstream from ATM in response to replication-mediated DNA double strand breaks |
| 16943424 |
These results demonstrate a sophisticated control by ATM of a target protein, Hdmx, which itself is one of several ATM targets in the ATM-p53 axis of the DNA damage response. |
| 17001622 |
Study reports the screening of 782 multiple-case breast cancer families that identified two additional index cases with ATM 7271T>G and phylogenetic sequence analysis showed that Valine2424 is a highly conserved residue. |
| 17008050 |
ATM regulates ionizing radiation-induced disruption of HDAC1:PP1:Rb complexes. |
| 17166884 |
current results support the association of two A-T-related ATM mutations, 6903insA and 7570G>C, in addition to 8734A>G, with breast cancer susceptibility |
| 17580311 |
Pre-mRNA secondary structure plays a major role on donor-site usage and splicing efficiency in ATM pseudoexon inclusion events. |
| 17544403 |
The S-phase checkpoint, regulated by the ATM-p95/NBS1-SMC1 pathway, was also triggered in hypoxia/reoxygenation-exposed lymphocytes. |
| 12234250 |
These observations provide the first link between ATM and LKB1 and suggest that ATM could regulate LKB1 |
| 15048089 |
Mre11-Rad50-Nbs1 complex serves also as a modulator/amplifier of ATM activity. |
| 15258567 |
p14ARF-induced inhibition of MCF7 cell proliferation was significantly attenuated by downregulation of ATM by RNAi. |
| 11805335 |
Missense mutations but not allelic variants alter the function of ATM by dominant interference in patients with breast cancer. |
| 15234984 |
Atm phosphorylation events are regulated by nibrin and Mre11-Rad50 |
| 11889466 |
A new type of mutation causes a splicing defect in ATM |
| 12376469 |
deficiency in the repair of UV-induced DNA damage in human skin fibroblasts compromised for the gene |
| 15574327 |
ATM, Artemis, and proteins locating to gamma-H2AX foci have roles in double-strand break rejoining |
| 15840767 |
activation of ATM contributes to high NaCl-induced nuclear translocation of TonEBP/OREBP |
| 16221684 |
ATM controls SV40 viral replication in vivo |
| 16329039 |
Reduced ATM expression in breast carcinomas correlated with tumor differentiation and increased microvascular parameters, supporting its role in neoangiogenesis and tumor progression in breast carcinogenesis. |
| 16426903 |
ATM is phosphorylated on serine-1981 in lymphoblastoid cell lines (LCLs) derived from Immunodeficiency, Centromeric instability, Facial anomalies syndrome (ICF) patients but not from the other syndromes. |
| 16481012 |
Plk3 is in a pathway linking ATM, Plk3, Chk2, Cdc25C and Cdc2 in cellular response to DNA damage. |
| 16631604 |
In conclusion, methylation of the ATM promoter may account for the variable radiosensitivity and heterogeneous ATM expression in a fraction of glioma cells. |
| 16651613 |
SUMOylation and activation of ataxia-telangiectasia-mutated protein, PKCdelta, caspase-3, and nuclear factor kappaB signaling pathways modulate salivary adaptive responses to stress in cells exposed to either 1% O(2) or DFO. |
| 16652348 |
Heterozygous mutations within the ATM gene are associated with the risk of breast cancer. |
| 16741947 |
ATR is one of the kinases that is likely involved in phosphorylation of Chk2 in response to ionizing radiation when ATM is deficient. |
| 16858402 |
There are at least three functionally important radiation-induced autophosphorylation events in ATM. |
| 16998505 |
Epidemiological and molecular studies have provided conclusive evidence that ATM mutations that cause ataxia-telangiectasia are breast cancer susceptibility alleles. [REVIEW] |
| 17019709 |
Increased ATM expression is associated with esophageal squamous cell carcinoma and its premalignant lesions |
| 17106266 |
ATM is activated during oxidative burst in phorbol ester-treated human leukocytes. |
| 11996792 |
The data are compatible with certain missense mutations in ATM predisposing to breast cancer. |
| 12149228 |
ATM mutations contribute to the development of diffuse large B-cell lymphoma |
| 11875057 |
mediates phosphorylation at multiple p53 sites in response to ionizing radiation |
| 12072552 |
dominant negative mutations in breast cancer families |
| 12409306 |
Data suggest that a novel AMPK family member, ARK5, is the tumor cell survival factor activated by Akt and acts as an ATM kinase under the conditions of nutrient starvation. |
| 12526805 |
ATM does not have a critical role in regulating chromosomal fragile site stability |
| 12773400 |
BRCA1 facilitates the ability of ATM and ATR to phosphorylate downstream substrates that directly influence cell cycle checkpoint arrest and apoptosis |
| 12860021 |
analyses of lymphocytes and DNA from 37 familial CLL cases do not support the hypothesis that the ATM gene is a CLL susceptibility gene |
| 12875964 |
Data suggest that ataxia telangiectasia mutated (ATM) expression is differentially regulated in lymphoid tumors and is likely to reflect their cellular origin. |
| 14628072 |
REVIEWS the ATM gene in sporadic lymphoid malignancies and the apparent paradox between the predominance of nonsense mutations observed in ataxia-telangiectasia patients and the high proportion of missense alterations found in sporadic lymphoid tumours |
| 15314656 |
TRF2 binds the ATM kinase and can inhibit the ATM-dependent DNA damage response |
| 12420214 |
ATM kinase has a role in orchestrating the coordinated induction and transcriptional cooperation of IRF-1 and p53 to regulate p21 expression. |
| 16326028 |
hypothesis that one molecular mechanism by which 11q23 deletions confer a poor prognosis in CLL is via increased TfR expression secondary to ATM loss, resulting in the increased cellular iron import, and hence increased capacity for malignant growth |
| 15456891 |
Data show that Artemis interacts with cell cycle checkpoint proteins and is a phosphorylation target of the checkpoint kinases ATM or ATR after exposure of cells to IR or UV irradiation, respectively. |
| 11992555 |
risk of developing BC is 3.6-fold higher among ATM heterozygous women |
| 12556884 |
Cellular irradiation induces rapid intermolecular autophosphorylation of serine 1981 that causes dimer dissociation and initiates cellular ATM kinase activity |
| 12513844 |
ATM protein plays a critical role in the signal transduction of cell cycle checkpoint, the repair of damaged DNA and the apoptosis. |
| 12637545 |
ATM is a major signal initiator for genotoxin-induced apoptosis but, paradoxically, also contributes to maintenance of cell survival by facilitating recovery/escape from terminal growth arrest |
| 14744762 |
ATM-deficient cells repair the majority of DSBs with normal kinetics but fail to repair a subset of breaks. |
| 15064416 |
demonstrated that MRN (Mre11, Rad50, and Nbs1 proteins) stimulates the kinase activity of ATM in vitro toward its substrates p53, Chk2, and histone H2AX |
| 12151394 |
These findings indicate that ATM activation is not limited to the ionizing radiation-induced response and potentially plays an important role in response to DNA alkylation. |
| 15345673 |
The present data suggests that the IGF-IR gene is a novel downstream target in an ATM-mediated DNA damage response pathway. |
| 16474843 |
ATM and MRN protein complex play role in recruiting ATR to sites of ionizing radiation-induced DNA damage |
| 16533773 |
Low expression of ATM was associated with colorectal cancer |
| 17030982 |
The response of promyelocytic leukemia nuclear bodies to DNA double-strand breaks is regulated by NBS1, ATM, Chk2, and ATR. |
| 17172861 |
Smad7 plays a crucial role upstream of ATM and p53 to protect the genome from insults evoked by extracellular stress. |
| 17189255 |
ATM mediates DNA-PKcs phosphorylation at Thr-2609 as well as at the adjacent (S/T)Q motifs within the Thr-2609 cluster. DNA-PKcs- and ATM-mediated DNA-PKcs phosphorylations are cooperative and required for the full activation of DNA-PKcs |
| 17350468 |
Deletion-specific probes detected a homozygous loss of two anonymous loci in chromosomal band 13q14 in parallel with a heterozygous loss of the ATM gene located in chromosomal band 11q22.3. |
| 12815592 |
Twenty eight novel mutations in the ATM gene have been identified and their associated haplotypes defined. |
| 14570874 |
ATM-dependent signaling pathway triggered by DNA damage is dispensable for activation of p38 MAPK and SIPS in response to IR or oxidative stress. |
| 14553952 |
study the null GSTM1 genotype is an independent risk factor for the development of lung cancer for Turkish population. |
| 15284180 |
Hexavalent chromium-induced activation of ATM involves the formation of S phase-dependent double stranded breaks. |
| 12813460 |
ATM is composed of two main domains comprising a head and an arm. DNA binding to ATM induces a large conformational movement of the arm-like domain which clamps around the double helix. |
| 16478990 |
nibrin plays an active role in Atm activation and that this function requires nibrin-Atm interaction. |
| 16631465 |
These observations document a high prevalence of ataxia telangiectasia mutated (ATM) gene and protein expression alterations, suggesting that ATM is involved in childhood non-Hodgkin lymphoma (NHL). |
| 16627474 |
nuclear ATM mediates the DSB response in NLCs similarly to in proliferating cells |
| 16824197 |
ATM (ataxia-telangiectasia mutated) is activated by a variety of noxious agent, including oxidative stress, and ATM deficiency results in an anomalous cellular response to oxidative stress. |
| 16849332 |
ataxia-telangiectasia mutated protein activation has a role in nucleotide excision repair-facilitated cell survival with cisplatin treatment |
| 16949371 |
Wip1 phosphatase is an integral component of an ATM-dependent signaling pathway. |
| 17164260 |
Common variants in the ATM and CHEK2 genes, in interaction with oestrogen-related exposures, are involved in endometrial cancer aetiology. |
