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SEPT2


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Symbol:SEPT2
Name(s):septin 2
Type:protein-coding
Organism:Homo sapiens
Synonyms:DIFF6, KIAA0158, NEDD5, Pnutl3, hNedd5
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18209106 Study shows that in epithelial cells septin 2 fibers colocalize with a subset of microtubule tracks composed of polyglutamylated tubulin.
17803907 Demonstrate connection between septins/SOCS7/NCK signaling and the DNA damage response.
17637674 crystal structures of the human SEPT2 G domain and the heterotrimeric human SEPT2-SEPT6-SEPT7 complex
15774761 septins may form a mitotic scaffold for CENP-E and other effectors to coordinate cytokinesis with chromosome congression and segregation
16682951 protein encoded by SEPT2 is highly homologous to septins 1, 4 and 5 and is involved in the coordination of several key steps of mitosis
15987492 Nedd5 C-terminal is a novel autoantigen in systemic lupus erythematosus (SLE) patients and may be a valuable tool for diagnosing neuropsychiatric SLE.
12125979 Nedd5 is involved in the process of cytokinesis in human brain tumours.
16914550 septin 2, 6, and 7 complexes make up polymerized filaments

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDNEDD5septin 5--Pubmed
HPRDNEDD5S100 calcium-binding protein A4--Pubmed
HPRDNEDD5syntaxin 1A--Pubmed
HPRDseptin 2Septin 5--Pubmed
HPRDseptin 2Syntaxin 1A--Pubmed
HPRDseptin 2Homo sapiens MLL septin-like fusion protein MSF-A mRNA, complete cds, alternatively spliced.--Pubmed

Recent Publications on SEPT2:

Pubmed Logo
GTP-induced conformational changes in septins and implications for function.
Septins constitute a group of GTP-binding proteins involved in cytokinesis...
7th October, 2009
Abteilung Strukturelle Biologie, Max-Planck-Institut fur molekulare Proc Natl Acad Sci U S A. 2009 Sep 29;106(39):16592-7. Epub 2009 Sep 15.
DOI Direct Link
Expression pattern of the septin gene family in acute myeloid leukemias with and without MLL-SEPT fusion genes.
Septins are proteins associated with crucial steps in cell division and...
15th September, 2009
Department of Genetics, Portuguese Oncology Institute, Porto, Portugal. Leuk Res. 2009 Sep 11.
DOI Direct Link
The phosphorylation of SEPT2 on Ser218 by casein kinase 2 is important to hepatoma carcinoma cell proliferation.
SEPT2 plays an important role in cell division through its effect on...
21st August, 2009
State Key Laboratory of Genetic Engineering, Institute of Genetics, School Mol Cell Biochem. 2009 May;325(1-2):61-7. Epub 2009 Jan 23.
DOI Direct Link
Both SEPT2 and MLL are down-regulated in MLL-SEPT2 therapy-related myeloid neoplasia.
BACKGROUND: A relevant role of septins in leukemogenesis has been...
8th July, 2009
Department of Genetics, Portuguese Oncology Institute, Porto, Portugal. BMC Cancer. 2009 May 15;9:147.
DOI Direct Link
PBMCs protein expression profile in relapsing IFN-treated multiple sclerosis: A pilot study on relation to clinical findings and brain atrophy.
This cross-sectional study investigated with two-dimensional gel...
7th July, 2009
Department of Biological and Environmental Sciences and Technologies, J Neuroimmunol. 2009 May 29;210(1-2):80-6. Epub 2009 Mar 29.
DOI Direct Link

View more research publications.

SEPT2 results (if any) from reagent suppliers

Google CSE Logo
Septin 2 (N-12) Antibody sc-20408
Human, SEPT2, 4735, 2q37.3, NM_001008491, NM_001008492, NM_004404, NM_006155 · Q15019 · 601506. Mouse, Sept2, 18000, 1 D, P42208 ...
http://www.scbt.com/datasheet-20408-septin-2-n-12-antibody.h...

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GeneTex Inc. - Your source for monoclonal, polyclonal, primary ...
Immunohistochemical analysis of paraffin-embedded H441, using SEPT2 (GTX101693) antibody at 1:100 dilution. Skip Navigation Links ...
http://genetex.com/WebPage/Product/ProductDetail.aspx?Catalo...

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Prediluted Monoclonal Antibody
1998 Sept;2(3):305-16. 3. Center for Disease Control Manual. Guide: Safety Management, NO. CDC-22,. Atlanta, GA. April 30, 1976 "Decontamination of ...
http://www.biocare.net/antibody-vp-datasheets/163VP.pdf...

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Septin Antibody / Septin Antibodies
製品名, カタログ番号, アイソタイプ, エピトープ, アプリケーション, 動物種. Septin 1 (E-13) 抗体, sc-20406, goat IgG, internal (h), WB, IP, IF, ELISA, h > m, ...
http://www.scbt.com/ja/table-septin.html...

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Acta Review Index
1969, 2, 1, Anonymous, 17 to 18, Computer Aids Search for R&D Chemicals, Reprinted from C&EN 1968, 46(Sept. 2), 26-27 ...
http://www.sigmaaldrich.com/chemistry/chemical-synthesis/lea...

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Non-coding rna has major role in controlling development of ...
2 Sep 2005 ... The findings were published in two papers in the Sept. 2 issue of the journal Science by the FANTOM Consortium for Genome Exploration ...
http://www.jax.org/news/archives/2005/noncoding_rna.html...

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EXPERIENCES WITH USING Y CHROMOSOME SPECIFIC STRS IN FORENSIC CASEWORK
Proceedings of the 17th Int. ISFH Congress; 1997 Sept 2-6; Oslo. Amsterdam: Elsevier 1998; 515-. 517. [3] Honda, K., Roewer, L., de Knijff, ...
http://www.promega.com/geneticidproc/ussymp10proc/content/38...

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