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NF1

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Symbol:	NF1
Name(s):	neurofibromin 1 (neurofibromatosis, von Recklinghausen disease, Watson disease)
Type:	protein-coding
Organism:	Homo sapiens
Synonyms:	DKFZp686J1293, NFNS, VRNF, WSS
Links:	Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications
Publication Link	Summary of findings
17914445	There is a statistically significant difference in the frequency of second hit NF1 mutations in cafe au lait spots (CALM) melanocytes compared with CALM fibroblasts, and with CALM keratinocytes.
12552569	Observational study of genetic testing. (HuGE Navigator)
14722914	Observational study of genotype prevalence and genetic testing. (HuGE Navigator)
15146469	Observational study of genotype prevalence and gene-disease association. (HuGE Navigator)
15389774	Observational study of gene-disease association. (HuGE Navigator)
15523626	Observational study of genotype prevalence. (HuGE Navigator)
16380919	Observational study of genotype prevalence. (HuGE Navigator)
17102080	Observational study of genotype prevalence. (HuGE Navigator)
18214791	The responsible gene and its protein product, neurofibromin have been identified.
18086893	In addition to providing the first mechanistic insight into tissue-specific control of NF1 splicing, these studies establish a novel strategy whereby Hu proteins regulate RNA processing.
→View more information from publications.

Interacting gene products
Interaction Type	Gene 1	Gene 2	Interaction description	Complex	Publication Link
HPRD	NMDA receptor 1 isoform NR1-3 precursor	Human neurofibromin gene, and translated products	-	-	Pubmed
HPRD	H-Ras	Human neurofibromin gene, and translated products	-	-	Pubmed
HPRD	v-Ha-ras Harvey rat sarcoma viral oncogene homolog isoform 1	Neurofibromatosis type I	-	-	Pubmed
HPRD	Neurofibromatosis type I	DNAJC7 protein	-	-	Pubmed
HPRD	Human neurofibromin gene, and translated products	DnaJ homolog subfamily C member 7	-	-	Pubmed

Recent Publications on NF1:
Widespread ischemic brain lesions caused by vasculopathy associated with neurofibromatosis type 1. We report the autopsy findings of a 63-year-old man with neurofibromatosis...	2nd February, 2010	Department of Pathology, Niigata University, Niigata, Japan.	Neuropathology. 2010 Jan 26. DOI Direct Link
Novel human pathological mutations. Gene symbol: SPRED1. Disease: Legius syndrome. We report the autopsy findings of a 63-year-old man with neurofibromatosis...	29th January, 2010	NF1 lab, Institute of Medical Genetics, University of Wales College of	Hum Genet. 2010 Jan;127(1):112.
Novel human pathological mutations. Gene symbol: SPRED1. Disease: Legius syndrome. We report the autopsy findings of a 63-year-old man with neurofibromatosis...	29th January, 2010	NF1 lab, Institute of Medical Genetics, University of Medical Genetics,	Hum Genet. 2010 Jan;127(1):111.
Novel human pathological mutations. Gene symbol: SPRED1. Disease: Legius syndrome. We report the autopsy findings of a 63-year-old man with neurofibromatosis...	29th January, 2010	NF1 lab, Institute of Medical Genetics, University of Wales College of	Hum Genet. 2010 Jan;127(1):111.
Novel human pathological mutations. Gene symbol: NF1. Disease: Neurofibromatosis 1. We report the autopsy findings of a 63-year-old man with neurofibromatosis...	29th January, 2010	Molecular Biology, NGHA, P O Box 22490, (2216), 11426, Riyadh, Saudi	Hum Genet. 2010 Jan;127(1):114.
→View more research publications.

Press Releases on NF1:
Novo Nordisk publish data demonstrating proof of concept for potassium	1st November, 2003	Dailyupdates	Novo Nordisk publish data demonstrating proof of concept for potassium channel openers as

Clinical Trials:
Trial to Evaluate the Safety of Lovastatin in Individuals With Neurofibromatosis Type I (NF1)

Patents:
US Patent No.	Title
7528255	Hydroxy, .omega.-carboxyaryl substituted diphenyl ureas and dirivatives thereof as raf kinase inhibitors
7554828	Power converter with retractable cable system
7556924	Detection of nucleic acid sequence differences using coupled ligase detection with padlock probes and polymerase chain reactions
7560253	HLS-5 tumor suppressor factor
7560438	Genetic inhibition by double-stranded RNA
→View more patents.

NF1 results from Abnova
Sponsored Results:
	NF1 polyclonal antibody (A01) Mouse polyclonal antibody raised against a partial recombinant NF1. Symbol: NF1 Alias: DKFZp686J1293, NFNS, VRNF, WSS http://www.abnova.com/products/products_detail.asp?catalog_id=H00004763-A01
	NF1 polyclonal antibody Rabbit polyclonal antibody raised against synthetic peptide of NF1. Symbol: NF1 Alias: DKFZp686J1293, FLJ21220, NFNS, VRNF, WSS http://www.abnova.com/products/products_detail.asp?catalog_id=PAB12717
	NF1 Pre-design Chimera RNAi Homo sapiens neurofibromin 1 (neurofibromatosis, von Recklinghausen disease, Watson disease) (NF1), transcript variant 1, mRNA Symbol: NF1 Alias: DKFZp686J1293, NFNS, VRNF, WSS http://www.abnova.com/products/products_detail.asp?catalog_id=H00004763-R02
	NF1 Pre-design Chimera RNAi Homo sapiens neurofibromin 1 (neurofibromatosis, von Recklinghausen disease, Watson disease) (NF1), mRNA. Symbol: NF1 Alias: DKFZp686J1293, NFNS, VRNF, WSS http://www.abnova.com/products/products_detail.asp?catalog_id=H00004763-R01
	NF1 monoclonal antibody (M01), clone 2D1 Mouse monoclonal antibody raised against a partial recombinant NF1. Symbol: NF1 Alias: DKFZp686J1293, NFNS, VRNF, WSS http://www.abnova.com/products/products_detail.asp?catalog_id=H00004763-M01
	NF1 (phospho S2515) polyclonal antibody Rabbit polyclonal antibody raised against synthetic phosphopeptides of NF1. Symbol: NF1 Alias: DKFZp686J1293, NFNS, VRNF, WSS http://www.abnova.com/products/products_detail.asp?catalog_id=PAB0543
→Search for NF1 products at Abnova.

NF1 results (if any) from reagent suppliers

NF-1 Antibody / NF-1 Antibodies NF-1 Antibody / NF-1 Antibodies. ... NF-1 specific siRNA, sHRNA Plasmid and shRNA Lentiviral Particles gene silencers are also available. ... http://www.scbt.com/table-nf-1.html...
NF1 Antibody Antibody Bethyl Laboratories Inactivating mutations in NF1 (neurofibromin 1) result in neurofibromatosis type I (NF1) which is characterized by Schwann cell neurofibromas, café-au-lait ... http://www.bethyl.com/product/A300-140A...
Phospho-NF1-S2515 Antibody Phospho-NF1-S2515 Antibody Cell Function, Phospho-NF1-S2515 Antibody Neurosciences, Phospho-NF1-S2515 Antibody Phospho-Specific, Phospho-NF1-S2515 Antibody ... http://www.abgent.com/catalog_no/AP3327a...
NF1 Antibody Bethyl Laboratories Inactivating mutations in NF1 (neurofibromin 1) result in neurofibromatosis ... At the cellular level, NF1 functions as a negative regulator of Ras activity. http://www.bethyl.com/category/NF1...
NSEP1 antibody, NSEP1 Antibody, Rabbit Polyclonal Antibody Synonym Names for NSEP1 antibody: NSEP1; BP-8, CSDB, DBPB, MDR-NF1, MGC110976, NSEP-1, YB-1, YB1, YBX1; Y-box-binding protein 1; Y-box transcription factor; ... http://www.genwaybio.com/product_info.php?products_id=42521...
Neurofibromin (D) Antibody sc-67 Urinary Bladder Transitional CellCarcinogenesis is Associated with Down- Regulation of NF1 Tumor Suppressor Gene in Vivo and In Vitro. Am. J. Pathology. ... http://www.scbt.com/datasheet-67-neurofibromin-d-antibody.ht...
Protein and Antibody Solutions Provider - GenWay Rabbit polyclonal to Neurofibromin; 4763; NF1; 162200; P21359; ... Mouse monoclonal anti-human NFIB antibody; Nuclear factor 1/B; NF1-B; NFI-B; NF-I/B; ... http://www.genwaybio.com/advanced_search_result.php?so=c&exa...

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NF1

Gene Information from Publications

Interacting gene products

Recent Publications on NF1:

Press Releases on NF1:

Clinical Trials:

Patents:

NF1 results from Abnova

Sponsored Results:

NF1 results (if any) from reagent suppliers