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NF1

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Symbol:	NF1
Name(s):	neurofibromin 1 (neurofibromatosis, von Recklinghausen disease, Watson disease)
Type:	protein-coding
Organism:	Homo sapiens
Synonyms:	DKFZp686J1293, NFNS, VRNF, WSS
Links:	Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications
Publication Link	Summary of findings
17914445	There is a statistically significant difference in the frequency of second hit NF1 mutations in cafe au lait spots (CALM) melanocytes compared with CALM fibroblasts, and with CALM keratinocytes.
12552569	Observational study of genetic testing. (HuGE Navigator)
14722914	Observational study of genotype prevalence and genetic testing. (HuGE Navigator)
15146469	Observational study of genotype prevalence and gene-disease association. (HuGE Navigator)
15389774	Observational study of gene-disease association. (HuGE Navigator)
15523626	Observational study of genotype prevalence. (HuGE Navigator)
16380919	Observational study of genotype prevalence. (HuGE Navigator)
17102080	Observational study of genotype prevalence. (HuGE Navigator)
18214791	The responsible gene and its protein product, neurofibromin have been identified.
18086893	In addition to providing the first mechanistic insight into tissue-specific control of NF1 splicing, these studies establish a novel strategy whereby Hu proteins regulate RNA processing.
→View more information from publications.

Interacting gene products
Interaction Type	Gene 1	Gene 2	Interaction description	Complex	Publication Link
HPRD	NMDA receptor 1 isoform NR1-3 precursor	Human neurofibromin gene, and translated products	-	-	Pubmed
HPRD	H-Ras	Human neurofibromin gene, and translated products	-	-	Pubmed
HPRD	v-Ha-ras Harvey rat sarcoma viral oncogene homolog isoform 1	Neurofibromatosis type I	-	-	Pubmed
HPRD	Neurofibromatosis type I	DNAJC7 protein	-	-	Pubmed
HPRD	Human neurofibromin gene, and translated products	DnaJ homolog subfamily C member 7	-	-	Pubmed

Recent Publications on NF1:
Multiple gastrointestinal stromal tumors in neurofibromatosis type 1: Report of a case. This report presents a case of multiple gastrointestinal stromal tumors...	3rd November, 2009	Department of Gastroenterological Surgery, Kumamoto University, 1-1-1	Surg Today. 2009;39(11):979-83. Epub 2009 Nov 1. DOI Direct Link
[Usefulness of systematic brain magnetic resonance imaging in children with neurofibromatosis type 1.] BACKGROUND AND AIM: The aim of this study was to evaluate the usefulness...	30th October, 2009	Service de neurologie pediatrique, hopital Femme-Mere-Enfant, hospices	Arch Pediatr. 2009 Oct 26. DOI Direct Link
Multiple spinal ganglioneuromas in a patient harboring a pathogenic NF1 mutation. Bacci C, Sestini R, Ammannati F, Bianchini E, Palladino T, Carella M,...	30th October, 2009	Department of Clinical Physiopathology, Medical Genetics Unit, University	Clin Genet. 2009 Oct 23. DOI Direct Link
[Hereditary diseases with propensity to myeloid malignancy] Hematological malignancy is known to be associated with Down syndrome...	29th October, 2009	Department of Pediatrics, Nihon University School of Medicine.	Nippon Rinsho. 2009 Oct;67(10):1884-8.
Plurifocal malignant peripheral nerve sheath tumor demonstrated by 18F-fluorodeoxyglucose positron emission tomography/computed tomography. Malignant peripheral nerve sheath tumors (MPNSTs) are sarcomas that derive...	27th October, 2009	Department of Nuclear Medicine, Spedali Civili di Brescia, Piazza Spedali	Jpn J Radiol. 2009 Oct;27(8):320-3. Epub 2009 Oct 27. DOI Direct Link
→View more research publications.

Press Releases on NF1:
Novo Nordisk publish data demonstrating proof of concept for potassium	1st November, 2003	Dailyupdates	Novo Nordisk publish data demonstrating proof of concept for potassium channel openers as

BioNews Results for NF1 :
Loss of Tumor Supressor Gene Essential in Transforming Benign Nerve Tumors into Cancers	Innovations Report: Oct 14 2009 11:12AM Matching: nf1
Loss Of Tumor Supressor Gene Essential To Transforming Benign Nerve Tumors Into Cancers	Red Orbit: Oct 13 2009 8:43PM Matching: nf1
Loss Of Tumor Supressor Gene Essential To Transforming Benign Nerve Tumors Into Cancers	Science Daily: Oct 13 2009 7:18PM Matching: nf1

Clinical Trials:
Neurofibromatosis Type 1 (NF1) and Tibial Dysplasia

Patents:
US Patent No.	Title
7490145	LiveException system
7528255	Hydroxy, .omega.-carboxyaryl substituted diphenyl ureas and dirivatives thereof as raf kinase inhibitors
7531356	Promoter sequences for corticotropin releasing-factor receptor CRF2.alpha. and method of identifying agents that alter the activity of the promoter sequences
7531562	Compositions and methods for protecting cells during cancer chemotherapy and radiotherapy
7534568	Methods for detection of a target nucleic acid by forming a cleavage structure with a cleavage resistant probe
→View more patents.

NF1 results (if any) from reagent suppliers

NF-1 Antibody / NF-1 Antibodies NF-1 Antibody / NF-1 Antibodies. ... NF-1 specific siRNA, sHRNA Plasmid and shRNA Lentiviral Particles gene silencers are also available. ... http://www.scbt.com/table-nf-1.html...
Monoclonal Anti-Neurofibromin antibody produced in mouse (N3537 ... Mutation in NF1 gene is one of the most common inherited human autosomal dominant disorders. ... functional and biochemical consequences of Nf1 ... http://www.sigmaaldrich.com/etc/medialib/docs/Sigma/Datashee...
< 다음 5 논문 > NF-1 (N-20) Antibody sc-870 NF-1 (N-20) Antibody sc-870. ... Western blot analysis of NF-1 expression in nuclear extracts prepared from PMA-treated HeLa ( A) ... http://www.scbt.com/ko/product.php?datasheet=870&page=4&tota...
NSEP1 antibody, NSEP1 Antibody, Rabbit Polyclonal Antibody Synonym Names for NSEP1 antibody: NSEP1; BP-8, CSDB, DBPB, MDR-NF1, MGC110976, NSEP-1, YB-1, YB1, YBX1; Y-box-binding protein 1; Y-box transcription factor; ... http://www.genwaybio.com/product_info.php?products_id=42521...
Neurofibromin (D) Antibody sc-67 NF1 Gene Expression in Mouse Fracture Healing and in Experimental Rat ... Characterization of functional elements in the neurofibromatosis (NF1) proximal ... http://www.scbt.com/datasheet-67-neurofibromin-d-antibody.ht...
Antibodies to Axon Guidance and Neuronal Development rat ... Nf1(24592) mouse ... Nf1(18015), mouse, human, rat, ARR, IHC, WB, pricing. N3287, Monoclonal Anti-Neuropilin-1 antibody produced in mouse, 130603 ... http://www.sigmaaldrich.com/etc/controller/controller-page.h...
Neurofibromin (N) Antibody sc-68 Characterization of functional elements in the neurofibromatosis (NF1) proximal ... Dynamic regulation of the Ras pathway via proteolysis of the NF1 tumor ... http://www.scbt.com/datasheet-68-neurofibromin-n-antibody.ht...

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NF1

Gene Information from Publications

Interacting gene products

Recent Publications on NF1:

Press Releases on NF1:

BioNews Results for NF1

Clinical Trials:

Patents:

NF1 results (if any) from reagent suppliers