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NF1


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Symbol:NF1
Name(s):neurofibromin 1 (neurofibromatosis, von Recklinghausen disease, Watson disease)
Type:protein-coding
Organism:Homo sapiens
Synonyms:DKFZp686J1293, NFNS, VRNF, WSS
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17914445 There is a statistically significant difference in the frequency of second hit NF1 mutations in cafe au lait spots (CALM) melanocytes compared with CALM fibroblasts, and with CALM keratinocytes.
12552569 Observational study of genetic testing. (HuGE Navigator)
14722914 Observational study of genotype prevalence and genetic testing. (HuGE Navigator)
15146469 Observational study of genotype prevalence and gene-disease association. (HuGE Navigator)
15389774 Observational study of gene-disease association. (HuGE Navigator)
15523626 Observational study of genotype prevalence. (HuGE Navigator)
16380919 Observational study of genotype prevalence. (HuGE Navigator)
17102080 Observational study of genotype prevalence. (HuGE Navigator)
18214791 The responsible gene and its protein product, neurofibromin have been identified.
18086893 In addition to providing the first mechanistic insight into tissue-specific control of NF1 splicing, these studies establish a novel strategy whereby Hu proteins regulate RNA processing.

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDNMDA receptor 1 isoform NR1-3 precursorHuman neurofibromin gene, and translated products--Pubmed
HPRDH-RasHuman neurofibromin gene, and translated products--Pubmed
HPRDv-Ha-ras Harvey rat sarcoma viral oncogene homolog isoform 1Neurofibromatosis type I--Pubmed
HPRDNeurofibromatosis type IDNAJC7 protein--Pubmed
HPRDHuman neurofibromin gene, and translated productsDnaJ homolog subfamily C member 7--Pubmed

Recent Publications on NF1:

Pubmed Logo
Widespread ischemic brain lesions caused by vasculopathy associated with neurofibromatosis type 1.
We report the autopsy findings of a 63-year-old man with neurofibromatosis...
2nd February, 2010
Department of Pathology, Niigata University, Niigata, Japan. Neuropathology. 2010 Jan 26.
DOI Direct Link
Novel human pathological mutations. Gene symbol: SPRED1. Disease: Legius syndrome.
We report the autopsy findings of a 63-year-old man with neurofibromatosis...
29th January, 2010
NF1 lab, Institute of Medical Genetics, University of Wales College of Hum Genet. 2010 Jan;127(1):112.
Novel human pathological mutations. Gene symbol: SPRED1. Disease: Legius syndrome.
We report the autopsy findings of a 63-year-old man with neurofibromatosis...
29th January, 2010
NF1 lab, Institute of Medical Genetics, University of Medical Genetics, Hum Genet. 2010 Jan;127(1):111.
Novel human pathological mutations. Gene symbol: SPRED1. Disease: Legius syndrome.
We report the autopsy findings of a 63-year-old man with neurofibromatosis...
29th January, 2010
NF1 lab, Institute of Medical Genetics, University of Wales College of Hum Genet. 2010 Jan;127(1):111.
Novel human pathological mutations. Gene symbol: NF1. Disease: Neurofibromatosis 1.
We report the autopsy findings of a 63-year-old man with neurofibromatosis...
29th January, 2010
Molecular Biology, NGHA, P O Box 22490, (2216), 11426, Riyadh, Saudi Hum Genet. 2010 Jan;127(1):114.

View more research publications.

Press Releases on NF1:

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Novo Nordisk publish data demonstrating proof of concept for potassium 1st November, 2003 Dailyupdates

Novo Nordisk publish data demonstrating proof of concept for potassium channel openers as

Clinical Trials:

Clinical Trials Logo
Trial to Evaluate the Safety of Lovastatin in Individuals With Neurofibromatosis Type I (NF1)

Patents:

Patents logo
US Patent No.Title
7528255 Hydroxy, .omega.-carboxyaryl substituted diphenyl ureas and dirivatives thereof as raf kinase inhibitors
7554828 Power converter with retractable cable system
7556924 Detection of nucleic acid sequence differences using coupled ligase detection with padlock probes and polymerase chain reactions
7560253 HLS-5 tumor suppressor factor
7560438 Genetic inhibition by double-stranded RNA

View more patents.

NF1 results from Abnova

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Sponsored Results:

Abnova Logo
NF1 polyclonal antibody (A01)
Mouse polyclonal antibody raised against a partial recombinant NF1.
Symbol: NF1  Alias: DKFZp686J1293, NFNS, VRNF, WSS
http://www.abnova.com/products/products_detail.asp?catalog_id=H00004763-A01
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Abnova Logo
NF1 polyclonal antibody
Rabbit polyclonal antibody raised against synthetic peptide of NF1.
Symbol: NF1  Alias: DKFZp686J1293, FLJ21220, NFNS, VRNF, WSS
http://www.abnova.com/products/products_detail.asp?catalog_id=PAB12717
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Abnova Logo
NF1 Pre-design Chimera RNAi
Homo sapiens neurofibromin 1 (neurofibromatosis, von Recklinghausen disease, Watson disease) (NF1), transcript variant 1, mRNA
Symbol: NF1  Alias: DKFZp686J1293, NFNS, VRNF, WSS
http://www.abnova.com/products/products_detail.asp?catalog_id=H00004763-R02
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Abnova Logo
NF1 Pre-design Chimera RNAi
Homo sapiens neurofibromin 1 (neurofibromatosis, von Recklinghausen disease, Watson disease) (NF1), mRNA.
Symbol: NF1  Alias: DKFZp686J1293, NFNS, VRNF, WSS
http://www.abnova.com/products/products_detail.asp?catalog_id=H00004763-R01
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Abnova Logo
NF1 monoclonal antibody (M01), clone 2D1
Mouse monoclonal antibody raised against a partial recombinant NF1.
Symbol: NF1  Alias: DKFZp686J1293, NFNS, VRNF, WSS
http://www.abnova.com/products/products_detail.asp?catalog_id=H00004763-M01
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Abnova Logo
NF1 (phospho S2515) polyclonal antibody
Rabbit polyclonal antibody raised against synthetic phosphopeptides of NF1.
Symbol: NF1  Alias: DKFZp686J1293, NFNS, VRNF, WSS
http://www.abnova.com/products/products_detail.asp?catalog_id=PAB0543
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Search for NF1 products at Abnova.

NF1 results (if any) from reagent suppliers

Google CSE Logo
NF-1 Antibody / NF-1 Antibodies
NF-1 Antibody / NF-1 Antibodies. ... NF-1 specific siRNA, sHRNA Plasmid and shRNA Lentiviral Particles gene silencers are also available. ...
http://www.scbt.com/table-nf-1.html...

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NF1 Antibody Antibody Bethyl Laboratories
Inactivating mutations in NF1 (neurofibromin 1) result in neurofibromatosis type I (NF1) which is characterized by Schwann cell neurofibromas, café-au-lait ...
http://www.bethyl.com/product/A300-140A...

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Phospho-NF1-S2515 Antibody
Phospho-NF1-S2515 Antibody Cell Function, Phospho-NF1-S2515 Antibody Neurosciences, Phospho-NF1-S2515 Antibody Phospho-Specific, Phospho-NF1-S2515
Antibody ...
http://www.abgent.com/catalog_no/AP3327a...

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NF1 Antibody Bethyl Laboratories
Inactivating mutations in NF1 (neurofibromin 1) result in neurofibromatosis ... At the cellular level, NF1 functions as a negative regulator of Ras activity.
http://www.bethyl.com/category/NF1...

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NSEP1 antibody, NSEP1 Antibody, Rabbit Polyclonal Antibody
Synonym Names for NSEP1 antibody: NSEP1; BP-8, CSDB, DBPB, MDR-NF1, MGC110976, NSEP-1, YB-1, YB1, YBX1; Y-box-binding protein 1; Y-box transcription factor;
...
http://www.genwaybio.com/product_info.php?products_id=42521...

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Neurofibromin (D) Antibody sc-67
Urinary Bladder Transitional CellCarcinogenesis is Associated with Down- Regulation of NF1 Tumor Suppressor Gene in Vivo and In Vitro. Am. J. Pathology.
...
http://www.scbt.com/datasheet-67-neurofibromin-d-antibody.ht...

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Protein and Antibody Solutions Provider - GenWay
Rabbit polyclonal to Neurofibromin; 4763; NF1; 162200; P21359; ... Mouse monoclonal anti-human NFIB antibody; Nuclear factor 1/B; NF1-B; NFI-B; NF-I/B;
...
http://www.genwaybio.com/advanced_search_result.php?so=c&exa...

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