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NFATC2
| Symbol: | NFATC2 | | Name(s): | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | KIAA0611, NFAT1, NFATP | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18097033 |
The promoter/enhancer activity of the NFAT-binding site in the TNF-alpha gene was up-regulated by NFATc2 but not by NFATc1, whereas both NFATs associated similarly with this region. |
| 18218901 |
study found that Homer2 and Homer3 are negative regulators of T cell activation; this is achieved through binding of nuclear factor of activated T cells (NFAT) and by competing with calcineurin |
| 17584983 |
NFAT1 mediates proinflammatory gene expression in response to mechanotransduction |
| 17882263 |
O-GlcNAc modification might be required for nuclear translocation of the transcription factors NFkappaB and NFAT |
| 17711847 |
the WIP-WASP complex plays an important role in WASP stabilization and NFAT activation |
| 17785820 |
NFAT1 is a critical regulator of CTLA-4 gene expression that binds to the CTLA-4 promoter in human T cells. |
| 17463169 |
NFAT1 could explain low FOXP3 expression and diminished Treg frequency in aplastic anemia. |
| 17588603 |
Changes in AP-1 composition and the level of participating NFAT proteins can differentially influence cytokine gene expression, resulting in biological consequences for the modulation and dynamics of the immune response. |
| 17398070 |
MAP3K8 and PRKCZ cooperate in the regulation of the transcriptional activity of NFATC2 through the phosphorylation of its amino-terminal domain. |
| 16497967 |
NFKB and NFAT regulate BLyS expression via at least one NFKB and 2 NFAT BLYS promoter binding sites. Constitutive activation of NFKB and BLyS in NHL-B cells forms a positive feedback loop associated with lymphoma cell survival and proliferation | →View more information from publications. |
Interacting gene products |
| Interaction Type |
Gene 1 |
Gene 2 |
Interaction description |
Complex |
Publication Link |
| HPRD | CREBBP | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 isoform C | - | - | Pubmed |
| HPRD | CREB binding protein | NFAT1 | - | - | Pubmed |
| HPRD | early growth response 1 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 isoform C | - | - | Pubmed |
| HPRD | early growth response 1 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 isoform C | - | - | Pubmed |
| HPRD | early growth response 4 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 isoform C | - | - | Pubmed |
| HPRD | early growth response 4 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 isoform C | - | - | Pubmed |
| HPRD | E1A binding protein p300 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 isoform C | - | - | Pubmed |
| HPRD | E1A binding protein p300 | NFAT1 | - | - | Pubmed |
| HPRD | v-fos FBJ murine osteosarcoma viral oncogene homolog | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 isoform C | - | - | Pubmed |
| HPRD | v-fos FBJ murine osteosarcoma viral oncogene homolog | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 isoform C | - | - | Pubmed |
Recent Publications on NFATC2: |  |
Poor in vitro induction of FOXP3 and ICOS in type 1 cytokine environment activated T-cells from children with type 1 diabetes.
BACKGROUND: Type 1 diabetes (T1D) is characterised by loss of tolerance to... | 1st November, 2008
| Department of Viral Diseases and Immunology, National Public Health
| Diabetes Metab Res Rev. 2008 Oct 30;24(8):635-641.
DOI Direct Link |
Negative regulators in homeostasis of naive peripheral T cells.
It is now apparent that naive peripheral T cells are a dynamic population... | 15th October, 2008
| Integrated Department of Immunology, University of Colorado-Denver,
| Immunol Res. 2008;41(2):137-53.
DOI Direct Link |
The transcription factor NFATc2 controls IL-6-dependent T cell activation in experimental colitis.
The nuclear factor of activated T cells (NFAT) family of transcription... | 20th September, 2008
| Institute of Molecular Medicine, Johanes Gutenberg Univeristy, 55131
| J Exp Med. 2008 Sep 1;205(9):2099-110. Epub 2008 Aug 18.
DOI Direct Link |
NFATc2 is a necessary mediator of calcineurin-dependent cardiac hypertrophy and heart failure.
One major intracellular signaling pathway involved in heart failure... | 18th September, 2008
| Hubrecht Institute and Interuniversity Cardiology Institute Netherlands,
| J Biol Chem. 2008 Aug 8;283(32):22295-303. Epub 2008 May 12.
DOI Direct Link |
Enforced expression of GATA3 allows differentiation of IL-17-producing cells, but constrains Th17-mediated pathology.
The zinc-finger transcription factor GATA3 serves as a master regulator of... | 16th September, 2008
| Department of Immunology, Erasmus MC Rotterdam, Rotterdam, The
| Eur J Immunol. 2008 Sep;38(9):2573-86.
DOI Direct Link |
→View more research publications. |
NFATC2 results (if any) from reagent suppliers | 
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HPA008789 Anti NFATC2 antibody produced in rabbit Prestige ...
HPA008789 Anti-NFATC2 antibody produced in rabbit Prestige Antibodies™ Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol ...
http://www.sigmaaldrich.com/catalog/search/ProductDetail/SIG...
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NFATc2 (4G6-G5) Antibody sc-7296
See how others have used NFATc2 (4G6-G5): sc-7296 and or NFATc2 (4G6-G5) ... Western blot analysis of NFATc2 isoform expression in Ramos whole cell lysate.
...
http://www.scbt.com/datasheet-7296-nfatc2-4g6-g5-antibody.ht...
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Phospho-NFATC2-pS326 Antibody
Phospho-NFATC2-pS326 Antibody. Peptide Affinity Purified Rabbit ... Background, NFATC2 is a member of the nuclear factor of activated T cells (NFAT) family. ...
http://www.abgent.com/products/catalog_no/AP3508a/background...
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NFATc2 (G1-D10) Antibody sc-7295
See how others have used NFATc2 (G1-D10): sc-7295 and or NFATc2 (G1-D10) antibody ... Western blot analysis of NFATc2 expression in Ramos whole cell
lysate ...
http://www.scbt.com/datasheet-7295-nfatc2-g1-d10-antibody.ht...
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WH0004773M1 Monoclonal Anti NFATC2 antibody produced in mouse ...
WH0004773M1 Monoclonal Anti-NFATC2 antibody produced in mouse clone 2A4, purified immunoglobulin, buffered aqueous solution.
http://www.sigmaaldrich.com/catalog/search/ProductDetail/SIG...
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NFATc2 (G-20) Antibody sc-23815
NFATc2 (G-20) P, sc-23815 P (peptide), 100 µg/0.5 ml, $58. NFATc2 (G-20) X, sc- 23815 X, 200 µg/0.1 ml ... NFATc2 shRNA Plasmid (h), sc-36055-SH, 20 µg ...
http://www.scbt.com/datasheet-23815-nfatc2-g-20-antibody.htm...
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Phospho-NFATC2-pS326 Antibody Blocking Peptide
NFATC2 is a member of the nuclear factor of activated T cells (NFAT) family. ... AP3508a: Phospho-NFATC2-pS326 Antibody. related Data Rewards Program ...
http://www.abgent.com/products/catalog_no/BP3508a...
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NFATc2 (M-20) Antibody sc-1151
NFATc2 (M-20) P, sc-1151 P (peptide), 100 µg/0.5 ml ... See how others have used NFATc2 (M-20): sc-1151 and or NFATc2 (M-20) antibody conjugates. ...
http://www.scbt.com/datasheet-1151-nfatc2-m-20-antibody.html...
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Eurogentec - Therapeutic - NFATc2 (E, WB), Polyclonal Antibody
Eurogentec is a leading provider of products and services for Life Science Research, in vitro Diagnostic and Therapeutic applications.
http://www.eurogentec.com/product/therapeutic-nfatc2-e-wb-po...
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p-NFATc2 (Ser 274) Antibody sc-68698
rabbit polyclonal IgG, 200µg/ml; epitope corresponding to phosphorylated Ser 274 of NFATc2 of human origin; recommended for detection of Ser 274 ...
http://www.scbt.com/datasheet-68698-r-p-nfatc2-ser-274-r-ant...
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