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NFKB2
| Symbol: | NFKB2 | | Name(s): | nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | LYT-10, LYT10 | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18025196 |
The findings demonstrate a key role for NF-kappaB2 in the regulation of RelA activation and suggest overlap in the function of NF-kappaB members in canonical and noncanonical pathway signaling. |
| 17715223 |
activation of NF-kappaB2/p100 plays a crucial role in the Tax1-mediated transformation of T cells |
| 17476277 |
cell adhesion-mediated proteolysis of the NF-kappaB precursor, p100 (NF-kappaB2) resulted in the generation of active p52, which translocated to the nucleus in complex with p65 and RelB |
| 12835724 |
p50 and p52 homodimers can transactivate the bcl-2 promoter through association with Bcl-3; in breast cancer and leukemic cells (CLL), high NF-kappaB2/p100 expression was associated with high Bcl-2 expression |
| 12894228 |
Constitutive processing of C-terminal truncation mutants of p100 is associated with their active nuclear translocation. , Mutation of the nuclear localization signal (NLS) of p100 abolishes its processing. |
| 17028057 |
We herein report that STP-A11 activates non-canonical NF-kappaB pathway, resulting in p100 processing to p52. |
| 16651533 |
Stat3-mediated p100 processing to p52 requires activation of Stat3 by the acetyltransferase activity of cAMP-response element-binding protein (CREB)-binding protein (CBP)/p300 |
| 12389034 |
NF-kappa B2 p100 has I kappa B-independent apoptotic activity and a unique tumour suppressor role |
| 17363471 |
C-terminally truncated NF-kappaB2 precursors are endoproteolytically processed at kappaB-containing promoters |
| 12874295 |
RelB has an effect on p100 processing, which is possibly regulated in a signal-dependent manner | →View more information from publications. |
Recent Publications on NFKB2: |  |
Combined genome-wide expression profiling and targeted RNA interference in primary mouse macrophages reveals perturbation of transcriptional networks associated with interferon signalling.
BACKGROUND: Interferons (IFNs) are potent antiviral cytokines capable of... | 1st October, 2009
| Division of Pathway Medicine, The University of Edinburgh, The
| BMC Genomics. 2009 Aug 10;10:372.
DOI Direct Link |
Effect of curcumin on nuclear factor kappaB signaling pathways in human chronic myelogenous K562 leukemia cells.
Curcumin, a natural product isolated from the plant Curcuma longa, has a... | 24th September, 2009
| Laboratoire de Biologie Moleculaire et Cellulaire du Cancer, Hopital
| Ann N Y Acad Sci. 2009 Aug;1171:436-47.
DOI Direct Link |
NF-kappaB2 (p100) limits TNF-alpha-induced osteoclastogenesis.
Bone undergoes a continuous cycle of renewal, and osteoclasts - the cells... | 23rd September, 2009
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| J Clin Invest. 2009 Oct;119(10):2879-81. doi: 10.1172/JCI40629. Epub 2009
DOI Direct Link |
Increased Levels of NOTCH1, NF-kappaB, and Other Interconnected Transcription Factors Characterize Primitive Sets of Hematopoietic Stem Cells.
As previously showed, higher levels of NOTCH1 and increased NF-kappaB... | 19th August, 2009
| Regional Blood Center and Faculty of Medicine - USP, Ribeirao Preto,
| Stem Cells Dev. 2009 Aug 17.
DOI Direct Link |
The genome-wide expression profile of Nelumbinis semen on lipopolysaccharide-stimulated BV-2 microglial cells.
This study was conducted to evaluate the protective mechanisms of... | 25th July, 2009
| Department of Physiology, College of Oriental Medicine, Kyung Hee
| Biol Pharm Bull. 2009 Jun;32(6):1012-20.
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→View more research publications. |
NFKB2 results (if any) from reagent suppliers | 
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Recent Citations: R&D Systems Products in Neuroscience-Related ...
Mouse anti-Human NFKB2 Monoclonal Antibody (Catalog # MAB2888) Sample Type: HEK293 human embryonic kidney cells expressing human APP with Swedish mutation
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http://www.rndsystems.com/cb_detail_objectname_su07_RecentCi...
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NFκB p52 (C-5) Antibody sc-7386
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, NFKB2, 4791, 10q24.32, NM_002502 ...
http://www.scbt.com/datasheet-7386-nfkappab-p52-c-5-antibody...
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NFkB p100 / p52 antibody (ab31432) | Abcam
There is a cleavage site on the NFKB2 (Swiss-Prot No.: Q00653). ... Subunits have been identified as p50 (NFkB1), p65 (RelA), c-Rel, RelB and p52 (NFkB2).
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http://www.abcam.com/NFkB-p100-p52-antibody-ab31432.html...
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NFKBIA antibody, NFKBIA Antibody, Rabbit Polyclonal Antibody
NFKB1 or NFKB2 is bound to REL. RELA. or RELB to form the NFKB complex. ... Summary: NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910),
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http://www.genwaybio.com/product_info.php?products_id=43046...
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RELA Antibody
NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA, or RELB (MIM 604758) to form the NFKB complex. The p50 (NFKB1)/p65 (RELA) ...
http://www.piercenet.com/products/Browse.cfm?fldID=FEAB8C1B-...
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IKK alpha antibody, IKK alpha phospho S176, S180 Antibody, Rabbit ...
As part of the non-canonical pathway of NF-kappa-B activation, the MAP3K14- activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB,
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http://www.genwaybio.com/product_info.php?products_id=196653...
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Phospho-NF-kB p65 (Ser536) (93H1) Rabbit mAb (Alexa Fluor® 647 ...
nfkb2 (p100/p52). Both p105 and p100 are proteolyti- ... Processing of nfkb2 p100 is regulated by. NIK and IKK1 (IKKα), which triggers the phosphorylation
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http://www.cellsignal.com/pdf/4887.pdf...
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