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ACO1


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Symbol:ACO1
Name(s):aconitase 1, soluble
Type:protein-coding
Organism:Homo sapiens
Synonyms:ACONS, IREB1, IREBP, IREBP1, IRP1
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17604281 analysis of the iron regulatory protein system
17613866 Hypertransfusional (>8 transfusions/year) iron in liver biopsies correlated with increased expression (RNA) for iron regulatory proteins 1 and 2 (3-, 9- to 11-fold) and hepcidin RNA: (5- to 8-fold), while ferritin H and L RNA remained constant.
17200797 Results describe thet effect of hypoxia on the binding and subcellular distribution of iron regulatory proteins 1 and 2.
17521334 Although the iron-responsive element does not itself hydrolyze ATP, its presence enhances iron regulatory protein-1's ATPase activity, and ATP hydrolysis results in loss of the complex in gel shift assays.
11812787 Structural changes associated with switching activities of human iron regulatory protein 1
12572667 functional in the activation of iron uptake
12972614 A phosphomimetic mutation at Ser-138 renders IRP1 sensitive to iron-dependent degradation.
17244191 Thus, proper folding of human iron regulatory protein 1 strongly depends on its cellular environment, in contrast to other members of the aconitase family.
16424901 IRP1 controls iron homeostasis during cell proliferation, inflammation, and in response to diseases altering cytosolic Fe-S cluster assembly or disassembly.
16503547 IRP1 activity level is higher in monocytes and macrophages of hereditary hemochrosis (HH) patients than in those of control subjects, and is increased in the duodenal samples of the patients with HH and iron-deficiency anemia.

View more information from publications.

Recent Publications on ACO1:

Pubmed Logo
Karyological characterization of the butterfly lizard (Leiolepis reevesii rubritaeniata, Agamidae, Squamata) by molecular cytogenetic approach.
Karyological characterization of the butterfly lizard (Leiolepis reevesii...
26th September, 2009
Department of Genetics, Faculty of Science, Kasetsart University, Bangkok, Cytogenet Genome Res. 2009;125(3):213-23. Epub 2009 Sep 4.
DOI Direct Link
Effect of nitric oxide on ethylene synthesis and softening of banana fruit slice during ripening.
The effects of nitric oxide (NO) on ethylene synthesis and softening of...
24th September, 2009
South China Botanical Garden, Chinese Academy of Sciences, Guangzhou J Agric Food Chem. 2009 Jul 8;57(13):5799-804.
DOI Direct Link
Proteomic Analysis Reveals a Synergistic Mechanism of Fluconazole and Berberine against Fluconazole-Resistant Candida albicans: Endogenous ROS Augmentation.
Our previous study showed that concomitant use of berberine (BBR) and...
17th September, 2009
Department of Pharmacology, School of Pharmacy, Second Military Medical J Proteome Res. 2009 Sep 28.
DOI Direct Link
Virus-induced gene silencing reveals the involvement of ethylene-, salicylic acid- and mitogen-activated protein kinase-related defense pathways in the resistance of tomato to bacterial wilt.
Bacterial wilt (BW), caused by Ralstonia solanacearum, is a devastating...
21st July, 2009
Graduate Institute of Plant Biology and Department of Life Science, Physiol Plant. 2009 Jul;136(3):324-35. Epub 2009 May 11.
DOI Direct Link
LeCTR2, a CTR1-like protein kinase from tomato, plays a role in ethylene signalling, development and defence.
Arabidopsis AtCTR1 is a Raf-like protein kinase that interacts with ETR1...
1st July, 2009
Plant Sciences Division, School of Biosciences, University of Nottingham, Plant J. 2008 Jun;54(6):1083-93. Epub 2008 Mar 13.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
7608395 Systemic lupus erythematosus diagnostic assay
5922556 Parkinson's disease tests
6107548 DNA sequences from muskmelon (Cucumis melo) related to fruit ripening
6204437 DNA constructs and plants incorporating them
6262346 Ripening-related DNAs from banana

View more patents.

ACO1 results (if any) from reagent suppliers

Google CSE Logo
ACO1 antibody, ACO1 (aconitase 1. soluble) Antibody, Rabbit ...
Buy quality rabbit ACO1 antibody (interacts with human rat), anti-ACO1, ACO1 ( aconitase 1. soluble) antibody, rabbit polyclonal antibody, ACO1 (aconitase 1.
...
http://www.genwaybio.com/product_info.php?products_id=43581...

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IRP-1 (H-64) Antibody sc-25535
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, ACO1, 48, 9p21.1, NM_002197 · P21399
...
http://www.scbt.com/datasheet-25535-irp-1-h-64-antibody.html...

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Abgent - Translation and Regulation Antibodies ...
AT1025aNEW, ACHE monoclonal antibody (M02), ELISA,WB-Ce, H. AT1026aNEW, ACO1 monoclonal antibody (M01), ELISA,S-ELISA,WB-Re, H ...
http://www.abgent.com/products/category/nuclear_signaling/tr...

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Aconitase 1 antibody (ab54718) | Abcam
Aconitase 1 (ACO1) also known as iron regulatory element binding protein 1 ( IREB1), is a cytosolic protein which binds to iron-responsive elements (IR...
http://www.abcam.com/Aconitase-1-antibody-ab54718.html...

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Abgent - Cell and Function Antibodies
AP7696aNEW, ACK1 Antibody (N-term), WB, E, H. AP7696eNEW, ACK1 Antibody (Y826), WB, E, H. AT1026a, ACO1 monoclonal antibody (M01), ELISA,S-ELISA,WB-Re, H ...
http://www.abgent.com/products/category/cell_function...

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IRP Antibody / IRP Antibodies
제품명, 카탈로그 번호, ISOTYPE, EPITOPE, APPLICATIONS, SPECIES. IRP-1 (E-12) Antibody, sc-166022, mouse IgG2a, N-terminal (h), WB, IP, IF, ELISA, m, r, h ...
http://www.scbt.com/ko/table-irp.html...

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