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NGFR


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Symbol:NGFR
Name(s):nerve growth factor receptor (TNFR superfamily, member 16)
Type:protein-coding
Organism:Homo sapiens
Synonyms:CD271, Gp80-LNGFR, TNFRSF16, p75(NTR), p75NTR
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18203754 Observational study of gene-disease association. (HuGE Navigator)
16215672 p75(NTR) and Fas receptors could share common signalling pathways.
18221326 Basal keratinocytes in oral lichen planus showed no or only weak cytoplasmic staining but in normal oral mucosa there was a clear cell membrane staining
18196575 p75(NTR) suppresses progression of human retinoblastoma and is a potential target for therapy.
12768436 Observational study of genotype prevalence. (HuGE Navigator)
15274039 Observational study of gene-disease association. (HuGE Navigator)
18081157 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
17971243 in astrocytomas, Trk receptors (TrkA, TrkB, TrkC) expression, but not p75NTR may promote tumor growth independently of grade
17619016 Data show that functional cooperation between TrkA and p75(NTR) accelerates neuronal differentiation by increased transcription of GAP-43 and p21(CIP/WAF) genes via ERK1/2 and AP-1 activities.
17947706 Nerve growth factor facilitates TLR4 signaling-induced maturation of human dendritic cells through LPS-up-regulated p75(NTR) via activation of p38 MAPK and NF-kappaB pathways

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDmyelin associated glycoprotein isoform a precursorNerve growth factor receptor--Pubmed
HPRDNecdinnerve growth factor receptor precursor--Pubmed
HPRDnecdinNerve growth factor receptor--Pubmed
HPRDnerve growth factor, beta polypeptidenerve growth factor receptor precursor--Pubmed
HPRDnerve growth factor, beta polypeptidenerve growth factor receptor precursor--Pubmed
BINDnerve growth factor, beta polypeptidenerve growth factor receptor precursorNGF interacts with p75NTR.-Pubmed
BINDnerve growth factor, beta polypeptidenerve growth factor receptor precursorp75NTR interacts with NGF.-Pubmed
HPRDNerve growth factor receptorTNF receptor-associated factor 4--Pubmed
HPRDNerve growth factor receptorsplicing factor, arginine/serine-rich 10--Pubmed
HPRDNerve growth factor receptorkinase D-interacting substrate of 220 kDa--Pubmed

Recent Publications on NGFR:

Pubmed Logo
Sertoli cell androgen receptor DNA binding domain is essential for the completion of spermatogenesis.
We examined the biological importance of Sertoli cell androgen receptor...
23rd October, 2009
Andrology Laboratory, ANZAC Research Institute, Concord Hospital, Sydney, Endocrinology. 2009 Oct;150(10):4755-65. Epub 2009 Jul 2.
DOI Direct Link
Dual response of BDNF to sublethal concentrations of beta-amyloid peptides in cultured cortical neurons.
Beta-amyloid (Abeta) deposition is one important pathological hallmark in...
14th October, 2009
Centro de Neurobiologia y Plasticidad del Desarrollo, Departamento de Neurobiol Dis. 2009 Oct 12.
DOI Direct Link
Growth factors/cytokines/defensins and apoptosis in periodontal pathologies.
In the recent past there has been an increased emphasis on morphogenetic...
24th September, 2009
Riga Stradins University, Institute of Stomatology, 20 Dzirciema Street, Stomatologija. 2009;11(2):48-54.
Natural killer cells kill human melanoma cells with characteristics of cancer stem cells.
Experimental and clinical data suggest that tumours harbour a cell...
10th September, 2009
Dipartimento di Medicina Sperimentale and Centro di Eccellenza per la Int Immunol. 2009 Jul;21(7):793-801. Epub 2009 Jun 2.
DOI Direct Link
Increased expression of nerve growth factor receptor and neural endopeptidase in the lesional skin of melasma.
BACKGROUND: Characteristic clinical features of melasma are symmetry of...
1st September, 2009
Department of Dermatology, Asan Medical Center, College of Medicine, Dermatol Surg. 2009 Aug;35(8):1244-50. Epub 2009 May 12.
DOI Direct Link

View more research publications.

Clinical Trials:

Clinical Trials Logo
Neurogenic Mechanisms in Burning Mouth Syndrome

Patents:

Patents logo
US Patent No.Title
7371388 Treatment of Sjogren's syndrome by administration of TR18 polypeptides
7447594 Molecular cardiotoxicology modeling
7452538 Death domain containing receptor 4 antibodies and methods
7465707 Methods of treatment with TR10 polypeptides
7476384 Death domain containing receptor 4 antibody and methods

View more patents.

NGFR results (if any) from reagent suppliers

Google CSE Logo
NGFR Antibody / NGFR Antibodies
NGFR Antibody / NGFR Antibodies. ... NGFR specific siRNA, sHRNA Plasmid and shRNA Lentiviral Particles gene silencers are also available. ...
http://www.scbt.com/table-ngfr.html...

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NGFR Antibody low affinity nerve growth factor receptor
NGFR antibody can be used for the detection of NGFR by Western blot at 1 ug/ml.,
http://www.prosci-inc.com/shop/catalog1/NGFR-Antibody-p-6307...

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Purified Anti-human CD271 NGFR Antibody Anti-CD271 - BioLegend
Purified Anti-human CD271 NGFR Antibody Anti-CD271 - CD271, also known as p75NTR , TNFRSF16, p75(NTR), Gp80-LNGFR, NGFR, is a type I transmembrane protein ...
http://www.biolegend.com/purified-anti-human-cd271-ngfr-anti...

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NGFR p75 (H-137) Antibody sc-8317
See how others have used NGFR p75 (H-137): sc-8317 antibody and or NGFR p75 (H- 137) ... Western blot analysis of human recombinant NGFR p75 fusion protein. ...
http://www.scbt.com/datasheet-8317-ngfr-p75-h-137-antibody.h...

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N3908 Anti-Nerve Growth Factor Receptor (NGFR p75) antibody ...
N3908 Anti-Nerve Growth Factor Receptor (NGFR p75) antibody produced in rabbit affinity isolated antibody, buffered aqueous solution.
http://www.sigmaaldrich.com/catalog/ProductDetail.do?D7=0&N5...

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NGFR p75 (H-92) Antibody sc-5634
See how others have used NGFR p75 (H-92): sc-5634 antibody and or NGFR p75 (H-92 ) ... Patterns of expression and function of the p75(NGFR) protein in ...
http://www.scbt.com/datasheet-5634-ngfr-p75-h-92-antibody.ht...

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p75 NGF Receptor antibody (ab8874) | Abcam
During early development, activation of NGFR p75 by NGF induces apoptotic cell death ... In rat Schwann cells, NGF binding to NGFR p75 activates NF kappaB, ...
http://www.abcam.com/p75-ngf-receptor-antibody-ab8874.html...

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