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NPM1


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Symbol:NPM1
Name(s):nucleophosmin (nucleolar phosphoprotein B23, numatrin)
Type:protein-coding
Organism:Homo sapiens
Synonyms:B23, MGC104254, NPM
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18261272 Observational study of gene-disease association. (HuGE Navigator)
18268276 Observational study of genotype prevalence. (HuGE Navigator)
17943167 AML cells are a major source of Ang-1 in leukemic bone marrow, especially in patients with NPM1 mutations
17690700 mutated NPM peptides can be presented by HLA molecules, suggesting that AML cells carrying cytoplasmic mutated NPM could induce an anti-leukaemic T-cell response
18192111 In this general and unselected AML patient population, NPM1 mutation was not a prognostic indicator of a favorable outcome.
15870172 Observational study of genotype prevalence. (HuGE Navigator)
15973451 Observational study of genetic testing. (HuGE Navigator)
16046528 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
16076867 Observational study of genotype prevalence. (HuGE Navigator)
16455956 Observational study of gene-disease association. (HuGE Navigator)

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDanaplastic lymphoma kinase Ki-1nucleophosmin 1 isoform 1--Pubmed
HPRDADP-ribosylation factor 1nucleophosmin 1 isoform 1--Pubmed
HPRDgrowth arrest and DNA-damage-inducible, alphanucleophosmin 1 isoform 1--Pubmed
BINDv-myc myelocytomatosis viral oncogene homologHomo sapiens chromosome 5, reference assembly.Myc interacts with NPM1 (B23)-Pubmed
HPRDnucleolinnucleophosmin 1 isoform 1--Pubmed
HPRDnucleolinnucleophosmin 1 isoform 1--Pubmed
HPRDnucleolar protein 1, 120kDanucleophosmin 1 isoform 1--Pubmed
BIND-exportin 1An unspecified isoform of NPM1 (NPM) interacts with XPO1 (CRM1).-Pubmed
HPRDNucleophosmin 1SWAP-70 protein--Pubmed
HPRDNucleophosmin 1basic helix-loop-helix transcription factor HAND2--Pubmed

Recent Publications on NPM1:

Pubmed Logo
Mutual exclusion of ASXL1 and NPM1 mutations in a series of acute myeloid leukemias.
The aim of the study was to present our experience in treating children...
30th October, 2009
Centre de Recherche en Cancerologie de Marseille, Laboratoire d'Oncologie Leukemia. 2009 Oct 29.
DOI Direct Link
[Classification of myeloid leukemias]
Myeloid leukemia in this series corresponds to the myeloid neoplasms of...
29th October, 2009
Hematoimmunology, School of Health Science, Faculty of Medicine, Nippon Rinsho. 2009 Oct;67(10):1853-62.
Detection of exon 12 type A mutation of NPM1 gene in IMS-M2 cell line.
Nucleophosmin 1 (NPM1), a protein that shuttles between the nucleus and...
27th October, 2009
Division of Ultrafine Structure, Department of Pathology, Research Leuk Res. 2009 Oct 23.
DOI Direct Link
Gene expression profiling in acute myeloid leukaemia (AML).
In view of the genetic heterogeneity of acute myeloid leukaemia (AML),...
27th October, 2009
Department of Stem Cell Transplantation, University Cancer Center Hamburg, Best Pract Res Clin Haematol. 2009 Jun;22(2):169-80.
DOI Direct Link
Influence of NPM1 and FLT3-ITD status on outcome in relapsed/refractory AML patients receiving salvage therapy including gemtuzumab ozogamicin.
Nucleophosmin 1 (NPM1), a protein that shuttles between the nucleus and...
23rd October, 2009
[1] Service d'Hematologie Clinique, CHU, Nantes, France [2] Universite de Leukemia. 2009 Oct 22.
DOI Direct Link

View more research publications.

BioNews Results for NPM1

: RSS Logo
BioPortfolio Logo
Mutual exclusion of ASXL1 and NPM1 mutations in a series of acute myeloid leukemias
Leukemia:  Oct 29 2009 1:40PM Matching: npm1
Influence of NPM1 and FLT3-ITD status on outcome in relapsed/refractory AML patients receiving salvage therapy including gemtuzumab ozogamicin
Leukemia:  Oct 22 2009 2:37PM Matching: npm1

Clinical Trials:

Clinical Trials Logo
Study of Chemotherapy in Combination With All-Trans Retinoic Acid (ATRA) With or Without Gemtuzumab Ozogamicin in Patients With Acute Myeloid Leukemia (AML) and Mutant Nucleophosmin-1 (NPM1) Gene Mutation

Patents:

Patents logo
US Patent No.Title
7608395 Systemic lupus erythematosus diagnostic assay
7354725 Kinase peptides and antibodies
7342390 Reference voltage generation circuit
7251568 Methods and compositions for regulating bone and cartilage formation
7235358 Methods and compositions for diagnosing and monitoring transplant rejection

View more patents.

NPM1 results (if any) from reagent suppliers

Google CSE Logo
NPM1 monoclonal antibody (M01)
NPM1 (AAH02398, 1 a.a. ~ 295 a.a) full length recombinant protein with GST tag. ... Immunofluorescence of monoclonal antibody to NPM1 (AT3085a) on HeLa cell ...
http://www.abgent.com/products/catalog_no/AT3085a_NPM1_monoc...

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NPM1 Antibody AbVantage™ Pack Bethyl Laboratories
Nucleophosmin (NPM1) is involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, ...
http://www.bethyl.com/product/A310-870A/NPM1_Antibody/AAAAAA...

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NPM1 - R&D Systems
NPM1. Products By Product Type. All Products for this Molecule · Antibodies · Legal; |; Sitemap. United States (change country); |; (800) 343-7475 ...
http://www.rndsystems.com/molecule_detail.aspx?m=4108...

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B0556 Monoclonal Anti-B23 antibody produced in mouse ~0.5 mg/mL ...
isotype, IgG1. Gene Information, human ... NPM1(4869). rat ... Npm1(25498). mouse ... Npm1(18148). shipped in, dry ice. storage temp. −20°C ...
http://www.sigmaaldrich.com/catalog/ProductDetail.do?D7=0&N5...

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Melanoma antibody, Melanoma [HMB45 + DT101 + BC199] Antibody ...
Interacts with NPM1/B23 and promotes its polyubiquitination and degradation, ... Binds to BCL6, E2F1, HUWE1, MDM2, MYC, NPM1/B23, TOP1/TOPOI and UBE2I/UBC9. ...
http://www.genwaybio.com/product_info.php?products_id=192073...

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B23 (3F291) Antibody sc-70392
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, NPM1, 4869, 5q35.1, NM_001037738, ...
http://www.scbt.com/datasheet-70392-b23-3f291-antibody.html...

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Abgent - Cancer Antibodies - Cancer
AP2834aNEW, NPM1 Antibody (N-term), WB, IHC, E, H. AT3085aNEW, NPM1 monoclonal antibody (M01), ELISA,IF,IHC-P,WB-Ce,WB-Re, H ...
http://www.abgent.com/products/category/cell_function/cancer...

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