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ATP2A2
| Symbol: | ATP2A2 | | Name(s): | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | ATP2B, DAR, DD, DKFZp686P0211, FLJ20293, FLJ38063, MGC45367, SERCA2 | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18164028 |
These results indicate that failure of nitric oxide to inhibit migration in vascular smooth muscle cells exposed to high glucose is due to oxidation of the SERCA reactive cysteine-674. |
| 17116488 |
Observational study of genotype prevalence. (HuGE Navigator) |
| 17439322 |
Observational study of gene-disease association. (HuGE Navigator) |
| 11244492 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17635506 |
The Japanese pedigree presented here has the same mutation, p.N767S, as three previously reported unrelated European families, establishing it as a common mutation in HDD. |
| 18071073 |
platelets from patients with type 2 diabetes mellitus, were found to have enhanced tyrosine nitration and inactivation of the sarcoplasmic endoplasmic reticulum Ca2+-ATPase (SERCA-2), elevated platelet [Ca2+]i, and activation of mu-calpain. |
| 17597815 |
Sp1 plays an important and positive role in ATP2A2 gene expression in normal human keratinocytes in vivo and in vitro. |
| 17526652 |
Histidine-rich Ca-binding protein may play a key role in the regulation of SR Ca cycling through its direct interactions with SERCA2 and triadin, mediating a fine cross talk between SR Ca uptake and release in the heart. |
| 17588601 |
The sarco(endo)plasmic reticulum Ca(2+) ATPase 2b (SERCA2b), which maintains high Ca(2+) concentration in the lumen of the endoplasmic reticulum, interacts specifically with the human delta opioid receptor. |
| 14749390 |
TRAM2, as a part of the translocon, is required for the biosynthesis of type I collagen by coupling the activity of SERCA2b with the activity of the translocon | →View more information from publications. |
Interacting gene products |
| Interaction Type |
Gene 1 |
Gene 2 |
Interaction description |
Complex |
Publication Link |
| HPRD | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 isoform 1 | B-cell lymphoma protein 2 alpha isoform | - | - | Pubmed |
| HPRD | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 isoform 1 | B-cell lymphoma protein 2 alpha isoform | - | - | Pubmed |
| HPRD | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 isoform 1 | tumor necrosis factor receptor 1 precursor | - | - | Pubmed |
| HPRD | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 isoform 1 | tumor necrosis factor receptor 2 precursor | - | - | Pubmed |
| HPRD | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 isoform 1 | phospholamban | - | - | Pubmed |
| HPRD | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 isoform 1 | TNFRSF1A-associated via death domain | - | - | Pubmed |
| HPRD | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 isoform 1 | TNFRSF1A-associated via death domain | - | - | Pubmed |
| HPRD | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 isoform 1 | S100 calcium binding protein A1 | - | - | Pubmed |
| HPRD | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 isoform 1 | TNF receptor-associated factor 6 | - | - | Pubmed |
Recent Publications on ATP2A2: |  |
No indications for HPV involvement in the hypertrophic skin lesions of a Darier disease case without ATP2A2 gene mutations.
Darier disease (DD) is a relatively common genodermatosis characterized by... | 29th October, 2009
| Department of Clinical and Experimental Medicine, Medical School of
| J Cutan Pathol. 2009 Sep;36(9):1005-9.
DOI Direct Link |
SR/ER-mitochondrial local communication: calcium and ROS.
Mitochondria form junctions with the sarco/endoplasmic reticulum (SR/ER),... | 23rd October, 2009
| Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson
| Biochim Biophys Acta. 2009 Nov;1787(11):1352-62. Epub 2009 Jun 13.
DOI Direct Link |
New mutations of Darier disease in Tunisian patients.
Darier's disease (DD, MIM 124200) also known as Darier-White disease and... | 23rd October, 2009
| Molecular Investigation of Genetic Orphan Diseases Research Unit, Institut
| Arch Dermatol Res. 2009 Sep;301(8):615-9. Epub 2009 Jun 2.
DOI Direct Link |
Markers of squamous cell carcinoma in sarco/endoplasmic reticulum Ca(2+) ATPase 2 heterozygote mice keratinocytes.
A mutation of Atp2a2 gene encoding the sarco/endoplasmic reticulum... | 21st October, 2009
| Department of Oral Biology, Brain Korea 21 Project, Oral Science Research
| Prog Biophys Mol Biol. 2009 Oct 17.
DOI Direct Link |
Impaired contractile function and calcium handling in hearts of cardiac-specific calcineurin b1-deficient mice.
To define the necessity of calcineurin (Cn) signaling for cardiac... | 9th October, 2009
| Departments of Medicine, Washington University School of Medicine, Center
| Am J Physiol Heart Circ Physiol. 2009 Oct;297(4):H1263-73. Epub 2009 Aug
DOI Direct Link |
→View more research publications. |
ATP2A2 results (if any) from reagent suppliers | 
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ATP2A2/SERCA2 Antibody #4388
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide (KLH-coupled) derived from a sequence around Leu32 of human ATP2A2/
SERCA2. ...
http://www.cellsignal.com/products/4388.html...
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Antibodies to Ion Pumps
ATP2A2(488), rat, mouse, guinea pig, rabbit, canine, human, IP, WB, pricing ... ATP2A2(488), pig, human, canine, rabbit, bovine, rat, ICC, IF (i), IHC (f), ...
http://www.sigmaaldrich.com/etc/controller/controller-page.h...
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ATP2A2/SERCA2 Antibody
detects endogenous levels of total ATP2A2/SERCA2 protein. ... ATP2A2/SERCA2. Antibodies are purified by protein A and peptide affinity chromatography. ...
http://www.cellsignal.com/pdf/4388.pdf...
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SERCA2 (N-19) Antibody sc-8095
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, ATP2A2, 488, 12q24.11, NM_001681, ...
http://www.scbt.com/datasheet-8095-serca2-n-19-antibody.html...
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SERCA2 Antibody Bethyl Laboratories
Alternate Names, ATP2A2: ATPase, Ca++ transporting, cardiac muscle, slow twitch 2; ATP2B, ... SERCA2 is also known as ATP2A2, ATP2B, DAR, DD, and MGC45367. ...
http://www.bethyl.com/product/A300-406A/SERCA2_Antibody/AAAA...
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Product Pathways: Ca / cAMP / Lipid Signaling
new, 4388 · ATP2A2/SERCA2 Antibody, W IP, H M R Mk. 9841 · Bisindolylmaleimide I , Hydrochloride · 2173 · Calbindin (C26D12) Rabbit mAb, W IP IHC-P, H M R ...
http://www.cellsignal.com/pathways/ca-camp-lipid-signaling.j...
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SERCA Antibody / SERCA Antibodies
PRODUCT NAME, CATALOG #, ISOTYPE, EPITOPE, APPLICATIONS, SPECIES. SERCA1 (6D138) Antibody, sc-73019, mouse IgG1, FL (rabbit), WB, IF, m, h, rabbit, dog ...
http://www.scbt.com/table-serca.html...
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