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ATP2B1

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Symbol:	ATP2B1
Name(s):	ATPase, Ca++ transporting, plasma membrane 1
Type:	protein-coding
Organism:	Homo sapiens
Synonyms:	PMCA1, PMCA1kb
Links:	Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications
Publication Link	Summary of findings
16933204	Despite similar total calcium contents, lower SERCA and PMCA activities were found in sacs associated with hydrocele compared to those associated with undescended testis suggest a difference among the levels of cytosolic calcium.
12851406	PMCA1 has a high sensitivity to degradation by calpain
16669348	This phenomenon correlates with the greater increase in [Ca2+]c induced by higher concentrations of thrombin, which further confirms that SERCA and PMCA activities are regulated by [Ca2+]c
15911623	modulation of PMCA has important effects in regulating the proliferation of human breast cancer MCF-7 cells, involving changes in cell cycle kinetics but not cell cycle arrest
12784250	role in the intracellular Ca(2+) extrusion of syncytiotrophoblast-like structure originating from the differentiation of cultured trophoblast cells isolated from human term placenta
16488415	Alterations in the region of the alternative splicing site A change the sensitivity to Ca(2+) of the human isoform 4 of the PMCA.
16328033	Inactivation of the PMCA1 gene is a frequent and early event during oral carcinogenesis, and gene expression may be regulated by an epigenetic mechanism.
16412504	PMCA activity is influenced by membrane lipid composition and structure. The naturally high degree of lipid order in plasma membranes such as those found in human lens may serve to support PMCA activity.
11786550	Plasma membrane Ca2+ ATPase isoform 2b interacts preferentially with Na+/H+ exchanger regulatory factor 2 in apical plasma membranes

Recent Publications on ATP2B1:
Analysis of the mouse high-growth region in pigs. In the mouse, homozygous animals for the high growth mutation show a...	22nd September, 2009	Department of Animal Science, Center for Integrated Animal Genomics, Iowa	J Anim Breed Genet. 2009 Oct;126(5):404-12. DOI Direct Link
Dietary calcium and 1,25-dihydroxyvitamin D3 regulate transcription of calcium transporter genes in calbindin-D9k knockout mice. The effect(s) of oral calcium and vitamin D(3) were examined on the...	31st July, 2009	Laboratory of Veterinary Biochemistry and Molecular Biology, College of	J Reprod Dev. 2009 Apr;55(2):137-42. Epub 2008 Dec 24.
Active Ca(2+) reabsorption in the connecting tubule. The kidney plays a crucial role in the maintenance of the body calcium...	25th July, 2009	Department of Physiology, Nijmegen Centre for Molecular Life Sciences,	Pflugers Arch. 2009 May;458(1):99-109. Epub 2008 Nov 7. DOI Direct Link
A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits. To identify genetic factors influencing quantitative traits of biomedical...	30th June, 2009	Center for Genome Science, National Institute of Health, Seoul, Korea.	Nat Genet. 2009 May;41(5):527-34. Epub 2009 Apr 26. DOI Direct Link
Genome-wide association study of blood pressure and hypertension. Blood pressure is a major cardiovascular disease risk factor. To date, few...	12th May, 2009	[1] National Heart, Lung, and Blood Institute's Framingham Heart Study,	Nat Genet. 2009 May 10. DOI Direct Link
→View more research publications.

Patents:
US Patent No.	Title
7611839	Methods for diagnosing RCC and other solid tumors
7208313	Combined growth factor-deleted and thymidine kinase-deleted vaccinia virus vector
7244571	Methods for producing Ex vivo models for inflammatory disease and uses thereof
7435548	Methods for producing ex vivo models for inflammatory disease and uses thereof
7482334	Therapeutic treatment methods
→View more patents.

ATP2B1 results (if any) from reagent suppliers

PMCA (H-300) Antibody sc-28765 Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, ATP2B1, 490, 12q21.33, NM_001001323, ... http://www.scbt.com/datasheet-28765-pmca-h-300-antibody.html...
Antibodies to Calcium Channels Atp2b1(29598), rat, WB, pricing. P1244, Anti-PMCA2 antibody produced in rabbit, (polyclonal), affinity isolated antibody, human ... ATP2B2(491), human, rat ... http://www.sigmaaldrich.com/etc/controller/controller-page.h...
PMCA (H-300) Antibody sc-28765 Human, ATP2B1, 490, 12q21.33, NM_001001323, NM_001682 · P20020 · 108731. Maus, Atp2b2, 11941, 6 E3, Q9R0K7, n.n.. Maus, Atp2b1, 67972, 10 C3, NP_080758 ... http://www.scbt.com/de/datasheet-28765-pmca-h-300-antibody.h...
3C-3E Monoclonal Anti-ATP2B1 antibody produced in mouse clone 3E2, purified immunoglobulin, buffered aqueous solution, 3E2 (monoclonal) ... http://www.sigmaaldrich.com/etc/controller/controller-page.h...
Abgent - Cell and Function Antibodies AT1234aNEW, ATP2A3 monoclonal antibody (M01), ELISA,IHC-P,S-ELISA,WB-Ce,WB-Re, H . AT1235aNEW, ATP2B1 monoclonal antibody (M01), ELISA,S-ELISA,WB-Re, H ... http://www.abgent.com/products/category/cell_function...
PMCA1 (C-16) Antibody sc-16488 Human, ATP2B1, 490, 12q21.33, NM_001001323, NM_001682 · P20020 · 108731. Maus, Atp2b1, 67972, 10 C3, NP_080758, n.n.. Produkte und Bestellinformationen ... http://www.scbt.com/de/datasheet-16488-pmca1-c-16-antibody.h...
PMCA Antibody / PMCA Antibodies 製品名, カタログ番号, アイソタイプ, エピトープ, アプリケーション, 動物種. PMCA ( H-300) 抗体, sc-28765, rabbit IgG, cytoplasmic (h), WB, IP, IF, ELISA, m, r, ... http://www.scbt.com/ja/table-pmca.html...

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ATP2B1

Gene Information from Publications

Recent Publications on ATP2B1:

Patents:

ATP2B1 results (if any) from reagent suppliers