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ATP2B2


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Symbol:ATP2B2
Name(s):ATPase, Ca++ transporting, plasma membrane 2
Type:protein-coding
Organism:Homo sapiens
Synonyms:PMCA2, PMCA2a, PMCA2i
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17488275 Our results indicate that a loss of PMCA such as occurs in aging brain likely leads to subtle disruptions in normal Ca(2+) signaling and enhanced susceptibility to stresses that can alter the regulation of Ca(2+) homeostasis.
16216224 We conclude that PMCA2 mRNA can be highly overexpressed in some breast cancer cells.
12784250 role in the intracellular Ca(2+) extrusion of syncytiotrophoblast-like structure originating from the differentiation of cultured trophoblast cells isolated from human term placenta
17234811 plasma-membrane calcium-pump isoform 2 mutants have roles in causing digenic deafness
12624087 Alternative splicing of the first intracellular loop of PMCA2 alters its membrane targeting
15926914 Decrease in PMCA2 transcript and protein levels and correlation between expression and disease course in two different allergic encephalomyelitis models further highlight the importance of this calcium pump in neuronal dysfunction during inflammation.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDATP2B2chapsyn-110--Pubmed
HPRDATP2B2postsynaptic density protein 95--Pubmed
HPRDATP2B2discs, large homolog 1--Pubmed
HPRDplasma membrane calcium ATPase 2 isoform 1Synapse associated protein 97--Pubmed
HPRDplasma membrane calcium ATPase 2 isoform 1Channel associated protein of synapse 110--Pubmed
HPRDplasma membrane calcium ATPase 2 isoform 1Synapse associated protein 90--Pubmed
HPRDplasma membrane calcium ATPase 2 isoform 1solute carrier family 9 isoform 3 regulator 2--Pubmed
HPRDplasma membrane calcium ATPase 2 isoform 1PDZ domain containing 11--Pubmed
BINDATPase, Ca++ transporting, plasma membrane 2chapsyn-110PMCA2b interacts with SAP93. This interaction was modeled on a demonstrated interaction between human PMCA2b and SAP93 from rat and an unspecified source.-Pubmed
BINDATPase, Ca++ transporting, plasma membrane 2postsynaptic density protein 95PMCA2b interacts with SAP90. This interaction was modeled on a demonstrated interaction between human PMCA2b and rat SAP90.-Pubmed

Recent Publications on ATP2B2:

Pubmed Logo
Identification of Novel Candidate Genes for Treatment Response to Risperidone and Susceptibility for Schizophrenia: Integrated Analysis Among Pharmacogenomics, Mouse Expression, and Genetic Case-Control Association Approaches.
BACKGROUND: Pharmacogenomic approaches based on genomewide sets of single...
24th October, 2009
MRC, Centre for Neuropsychiatric Genetics and Genomics, Department of Biol Psychiatry. 2009 Oct 21.
DOI Direct Link
Tonotopic gradient in the developmental acquisition of sensory transduction in outer hair cells of the mouse cochlea.
Inner ear hair cells are exquisite mechanosensors that transduce nanometer...
4th August, 2009
Department of Neuroscience, University of Virginia School of Medicine, J Neurophysiol. 2009 Jun;101(6):2961-73. Epub 2009 Apr 1.
DOI Direct Link
Life and death of sensory hair cells expressing constitutively active TRPML3.
The varitint-waddler mutation A419P renders TRPML3 constitutively active,...
1st July, 2009
Departments of Otolaryngology-Head and Neck Surgery and Molecular and J Biol Chem. 2009 May 15;284(20):13823-31. Epub 2009 Mar 19.
DOI Direct Link
Apical localization of PMCA2w/b is lipid raft-dependent.
Alternative splicing of the first intracellular loop differentially...
10th June, 2009
Department of Biochemistry and Molecular Biology, College of Medicine, Biochem Biophys Res Commun. 2009 Jun 19;384(1):32-6. Epub 2009 Apr 18.
DOI Direct Link
Sarcolemmal Ca2+-ATPase ability to transport Ca2+ gradually diminishes after myocardial infarction in the rat.
AIMS: Plasmalemmal Ca(2+)-ATPase (PMCA) is involved in Ca(2+) handling and...
27th March, 2009
Department of Clinical Physiology, Postgraduate Medical School, Marymoncka Cardiovasc Res. 2009 Feb 15;81(3):546-54. Epub 2008 Oct 22.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
7588771 Microorganisms for therapy
7588767 Microorganisms for therapy
7547687 Therapeutic treatment methods
7510845 Assay employing G protein-coupled receptor expressed in dorsal root ganglia
7482334 Therapeutic treatment methods

View more patents.

ATP2B2 results (if any) from reagent suppliers

Google CSE Logo
PMCA2 (28) Antibody sc-136043
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, ATP2B2, 491, 3p25.3, Q01814 ...
http://www.scbt.com/datasheet-136043-pmca2-28-antibody.html...

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Antibodies to Calcium Channels
ATP2B2(491), human, rat, WB, pricing. P1369, Anti-PMCA3 antibody produced in rabbit, (polyclonal), affinity isolated antibody, rat ... Atp2b3(29599) ...
http://www.sigmaaldrich.com/etc/controller/controller-page.h...

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PMCA (H-300) Antibody sc-28765
Mouse, Atp2b2, 11941, 6 E3, Q9R0K7, N/A. Mouse, Atp2b1, 67972, 10 C3, NP_080758, N/A. Mouse, Atp2b3, 320707, X A7.3, NP_796210 ...
http://www.scbt.com/datasheet-28765-pmca-h-300-antibody.html...

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Search Results
Stock# - 001276 Strain name - C3H/HeJ-Atp2b2/J JAX® Mice Database Site Section: JAX® Mice and services · jaxmice.jax.org/strain/001276.html - 39Kb ...
http://www.jax.org/search/Main.jsp?sg=4&qt=chromosomal&page=...

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PMCA (H-300) Antibody sc-28765
Maus, Atp2b2, 11941, 6 E3, Q9R0K7, n.n.. Maus, Atp2b1, 67972, 10 C3, NP_080758, n.n.. Maus, Atp2b3, 320707, X A7.3, NP_796210 ...
http://www.scbt.com/de/datasheet-28765-pmca-h-300-antibody.h...

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Search Results
A-Atp2b2/J JAX® Mice Database Site Section: JAX® Mice and services · jaxmice.jax.org/strain/002894.html - 34Kb. Page 3 of 12 results «‹12345678›»
http://www.jax.org/search/Main.jsp?sg=4&qt=modifiers&page=3...

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PMCA (H-300) Antibody sc-28765
Mouse, Atp2b2, 11941, 6 E3, Q9R0K7, 없음. Mouse, Atp2b1, 67972, 10 C3, NP_080758 , 없음. Mouse, Atp2b3, 320707, X A7.3, NP_796210 ...
http://www.scbt.com/ko/datasheet-28765-pmca-h-300-antibody.h...

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