Tuesday November 24 2009 | Biotechnology feed | All feeds

BioPortfolio Biotechnology Pharmaceutical Healthcare Medical Life Science Drug Discovery Disease

OCLN


Suggest Content
Advertise Here
Gene DB Home
Symbol:OCLN
Name(s):occludin
Type:protein-coding
Organism:Homo sapiens
Synonyms:-
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17855770 Complete/partial truncation of the COOH-terminal tail of occludin did not prevent targeting to epithelial cell tight junctions. TM4 deletions abolished tight junction targeting.
18005733 B coxsackievirus entry depends on occludin and require the activity of Rab34, Ras, and Rab5, GTPases known to regulate macropinocytosis.
17635647 Selected neurons, astrocytes and oligodendrocytes expressed occludin, in all cases studied.
17553883 Rhesus monkey rotavirus infection of Caco-2 cells induced the disappearance of occludin.
15806147 Tight junction protein occludin has a potent inhibitory effect on the Raf1-mediated tumorigenesis
15659655 distinct properties for these two extracellular segments of the occludin protein and provide an improved understanding of how specific domains of occludin may interact with proteins present at tight junction structures
17038551 Estrogen modulates tight junctional resistance through estrogen receptor-alpha-mediated remodeling of occludin
17243118 OCLN accumulated at cell-to-cell junctions of the breast neoplasm cell line.
15500294 The occludin present in the tight junctions in HepG2 cells .
17359339 Tight junction proteins contribute to the permeability barrier in epidermal keratinocytes

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDgap junction protein, beta 1, 32kDaOccludin--Pubmed
HPRDgap junction protein, beta 1, 32kDaoccludin--Pubmed
HPRDOccludintight junction protein 2 isoform 1--Pubmed
HPRDOccludinviral oncogene yes-1 homolog 1--Pubmed
HPRDOccludintight junction protein 3--Pubmed
HPRDOccludintight junction protein 3--Pubmed
HPRDOccludinE3 ubiquitin-protein ligase Itchy homolog.--Pubmed
HPRDoccludinTight junction protein 2--Pubmed
HPRDoccludinItch--Pubmed
HPRDoccludinc-Yes--Pubmed

Recent Publications on OCLN:

Pubmed Logo
Novel STAT3 target genes exert distinct roles in the inhibition of mesoderm and endoderm differentiation in cooperation with Nanog.
Leukemia inhibitory factor (LIF) activates the transcription factor signal...
23rd June, 2009
Institut National de la Sante et de la Recherche Medicale, U846, Bron, Stem Cells. 2009 Aug;27(8):1760-71.
DOI Direct Link
VEGF-mediated disruption of endothelial CLN-5 promotes blood-brain barrier breakdown.
Breakdown of the blood-brain barrier (BBB) is an early and significant...
11th March, 2009
Corinne Goldsmith Dickinson Center for Multiple Sclerosis and Department Proc Natl Acad Sci U S A. 2009 Feb 10;106(6):1977-82. Epub 2009 Jan 27.
DOI Direct Link
Human occludin is a hepatitis C virus entry factor required for infection of mouse cells.
Hepatitis C virus (HCV) is a leading cause of liver disease worldwide. The...
21st February, 2009
Center for the Study of Hepatitis C, The Rockefeller University, New York, Nature. 2009 Feb 12;457(7231):882-6. Epub 2009 Jan 28.
DOI Direct Link
Claudin-1 is a metastasis suppressor and correlates with clinical outcome in lung adenocarcinoma.
RATIONALE: Claudin (CLDN)-1, a key component of tight junction complexes,...
24th January, 2009
Graduate Institute of Life Sciences, National Defense Medical Center, Am J Respir Crit Care Med. 2009 Jan 15;179(2):123-33. Epub 2008 Sep 11.
DOI Direct Link
Genome-wide identification of aberrantly methylated promoter associated CpG islands in acute lymphocytic leukemia.
We performed a genome-wide analysis of promoter associated CpG island...
13th September, 2008
Department of Leukemia, University of Texas MD Anderson Cancer Center, Leukemia. 2008 Aug;22(8):1529-38. Epub 2008 Jun 5.
DOI Direct Link

View more research publications.

OCLN results (if any) from reagent suppliers

Google CSE Logo
OCLN Antibody a component of tight junction strands
OCLN antibody can be used for detection of OCLN by Western blot at 1 - 2 μg/ml.,
http://www.prosci-inc.com/shop/catalog1/OCLN-Antibody-p-6909...

Thumbshot
Occludin (N-19) Antibody sc-8145
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, OCLN, 4950, 5q13.2, NM_002538 ...
http://www.scbt.com/datasheet-8145-occludin-n-19-antibody.ht...

Thumbshot
Products :: ProSci Incorporated
OCLN Antibody · SCARB1 Antibody · CD81 Antibody · MACC1 Antibody (IN) · MC4R Antibody · RGS21 Antibody · Fibulin 3 Antibody · SHOC2 Antibody ...
http://www.prosci-inc.com/shop/home.php...

Thumbshot
PhosphoSignature™
OCLN. Occludin. Q16625. 59. 287. SNILWDKEHIyDEQPPNVEEWVK ...... OCLN ezrin. CDLN3. CTNNB. DLG3. Iressa adhesion cytoskeletal reorganization survival ...
http://www.cellsignal.com/technologies/phosphoscan/pdfs/PSig...

Thumbshot
New Antibodies :: ProSci Incorporated
OCLN Antibody · ODZ3 Antibody · op18 Antibody (CT) · op18 Antibody (NT) · ORAI1 Antibody · ORAI1 Antibody (CT) · ORAI1 Monoclonal Antibody ...
http://www.prosci-inc.com/new-antibodies.php...

Thumbshot

Search Bioportfolio and other Life Science Sites for OCLN, or search for OCLN on BioPortfolio's antibody search engine.
This page has been viewed 147 times
Recent Search Terms used to find this page:
occludin | Occludin OCLN rat antibody | .


Resources from the NCBI used on this page, NCBI's standard disclaimer applies.

 

Nothing in this website should be used in place of personal medical advice from your own qualified medical practitioner.

All rights reserved. All other trademarks recognized.
Copyright 1997-2009 - BioPortfolio Limited.