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ODC1


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Symbol:ODC1
Name(s):ornithine decarboxylase 1
Type:protein-coding
Organism:Homo sapiens
Synonyms:ODC
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
12810952 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
15734972 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
17047198 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
17957960 Among colorectal cancer patients, ODC activity in cancer tissue was correlated with T factors, lymph node metastasis and stages.
17569126 The expression of ornithine decarboxylase is positively correlated with the degree of malignity of gastric mucosa and development of gastric lesions.
15534104 MTAP activity is frequently lost, and ODC activity is frequently elevated in both pancreatic adenocarcinoma and neuroendocrine tumors
17088079 This is the first report showing the existence of a causal relationship between ornithine decarboxylase expression, Erk and p38 MAP kinase activation, and MMP-2 expression.
16520895 Data suggest that prolaction-mediated induction of ornithine decarboxylase activity enhances expression of Bcl-2 strongly enough to bring about prolactin's anti-apoptotic function.
11830503 Overexpression of ornithine decarboxylase enhances endothelial proliferation by suppressing endostatin expression.
16219697 Data show that expressing whole proteins, protein domains, or peptide ligands fused to the N terminus of ornithine decarboxylase promotes proteasome-dependent degradation of these chimeric fusion proteins and their interacting cellular target proteins.

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDornithine decarboxylase antizyme 1Ornithine decarboxylase 1--Pubmed
HPRDornithine decarboxylase antizymeOrnithine decarboxylase 1--Pubmed

Recent Publications on ODC1:

Pubmed Logo
Associations of a polymorphism in the ornithine decarboxylase gene with colorectal cancer survival.
PURPOSE: Activity of ornithine decarboxylase (ODC), the first enzyme in...
1st October, 2009
Department of Epidemiology, University of California, Irvine, California Clin Cancer Res. 2009 Oct 1;15(19):6208-16. Epub 2009 Sep 29.
DOI Direct Link
Select nutrients in the ovine uterine lumen. V. Nitric oxide synthase, GTP cyclohydrolase, and ornithine decarboxylase in ovine uteri and peri-implantation conceptuses.
Nitric oxide (NO) and polyamines are critical for implantation and...
23rd September, 2009
Center for Animal Biotechnology and Genomics, Texas A&M University, Biol Reprod. 2009 Jul;81(1):67-76. Epub 2009 Feb 25.
DOI Direct Link
ODC1 is a critical determinant of MYCN oncogenesis and a therapeutic target in neuroblastoma.
Neuroblastoma is a frequently lethal childhood tumor in which MYC gene...
17th January, 2009
Division of Oncology, The Children's Hospital of Philadelphia, Department Cancer Res. 2008 Dec 1;68(23):9735-45.
DOI Direct Link
Impaired skeletal muscle development and function in male, but not female, genomic androgen receptor knockout mice.
To identify mechanisms of anabolic androgen action in muscle, we generated...
4th September, 2008
Department of Medicine, University of Melbourne, Austin Health, FASEB J. 2008 Aug;22(8):2676-89. Epub 2008 Apr 7.
DOI Direct Link
Identification of predictive biomarkers for the histone deacetylase inhibitor belinostat in a panel of human cancer cell lines.
Histone deacetylase inhibitors (HDACi) are promising epigenetic cancer...
21st August, 2008
Experimental Pathology Unit, National University Hospital, Copenhagen Cancer Biomark. 2008;4(2):101-9.

View more research publications.

Patents:

Patents logo
US Patent No.Title
7608395 Systemic lupus erythematosus diagnostic assay
5744131 Sequence-directed DNA-binding molecules compositions and methods
5869241 Method of determining DNA sequence preference of a DNA-binding molecule
6010849 Sequence-directed DNA binding molecules compositions and methods
6169615 Wavelength division multiplex optical transmission apparatus

View more patents.

ODC1 results (if any) from reagent suppliers

Google CSE Logo
ODC (N-15) Antibody sc-21515
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, ODC1, 4953, 2p25.1, NM_002539 ...
http://www.scbt.com/datasheet-21515-odc-n-15-antibody.html...

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Antibodies for Nitric Oxide Research
ascites fluid, mouse ... Odc1(18263) human ... ODC1(4953), human, mouse, ARR, ELISA (i), IHC (p), IP, WB, pricing. Sigma Aldrich Logo. Site Use Terms ...
http://www.sigmaaldrich.com/etc/controller/controller-page.h...

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Ornithine Decarboxylase (ODC) Ab-1 (Clone MP16-2)
ODC1. Applications: • Immunohistology (Frozen only). • Western Blotting1 (Not verified). The optimal dilution for a specific application should ...
http://www.labvision.com/pdf/464.pdf...

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ODC (N-15) Antibody sc-21515
Spezies, Gen, Gen ID, Chromosomaler Locus, mRNA (Isoform) Accession #, Protein Accession #, OMIM™ Nummer. Human, ODC1, 4953, 2p25.1, NM_002539 · P11926 ...
http://www.scbt.com/de/datasheet-21515-odc-n-15-antibody.htm...

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D193 DL-α-Difluoromethylornithine hydrochloride hydrate DFMO ...
assay, ≥97% (NMR). form, solid. color, white. solubility, H2O: >10 mg/mL, soluble. DMSO: <2 mg/mL, insoluble. Gene Information, human ... ODC1(4953) ...
http://www.sigmaaldrich.com/catalog/ProductDetail.do?N4=D193...

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Select Nutrients in the Ovine Uterine Lumen. VI. Expression of ...
18 Mar 2009 ... factor 2 (IGF2), ornithine decarboxylase 1 (ODC1) and nitric oxide synthases ( NOS) [13-15]. Additionally, FRAP1 promotes translation of the ...
http://www.abgent.com/downloads/Select_Nutrients_in_the_Ovin...

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D13208 1,4-Diaminobutane 99%
refractive index, n 20/D 1.457(lit.) bp, 158-160 °C(lit.) mp, 25-28 °C(lit.) density, 0.877 g/mL at 25 °C(lit.) Gene Information, rat ... Odc1(24609) ...
http://www.sigmaaldrich.com/catalog/ProductDetail.do?D7=0&N5...

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