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OGDH


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Gene DB Home
Symbol:OGDH
Name(s):oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
Type:protein-coding
Organism:Homo sapiens
Synonyms:AKGDH, E1k, OGDC
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17343268 Association with autosomal recessive DOOR syndrome not found.
15466852 2-oxoglutarate (alpha-ketoglutarate) dehydrogenase stability is regulated by the RING finger ubiquitin ligase Siah
15649899 Reduction in the E2k subunit of the alpha-ketoglutarate dehydrogenase complex has effects independent of complex activity.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDdihydrolipoamide dehydrogenase precursoroxoglutarate dehydrogenase isoform 1 precursor--Pubmed
HPRDdihydrolipoamide dehydrogenase precursoroxoglutarate dehydrogenase isoform 1 precursor--Pubmed
HPRDdihydrolipoamide S-succinyltransferaseoxoglutarate dehydrogenase isoform 1 precursor--Pubmed
HPRDdihydrolipoamide S-succinyltransferaseoxoglutarate dehydrogenase isoform 1 precursor--Pubmed

Recent Publications on OGDH:

Pubmed Logo
Phosphono analogues of 2-oxoglutarate protect cerebellar granule neurons upon glutamate excitotoxicity.
Glutamate excitotoxicity is an important contributor to neuronal loss....
24th September, 2009
Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State Ann N Y Acad Sci. 2009 Aug;1171:521-9.
DOI Direct Link
Novel isoenzyme of 2-oxoglutarate dehydrogenase is identified in brain, but not in heart.
2-Oxoglutarate dehydrogenase (OGDH) is the first and rate-limiting...
25th December, 2008
Bioengineering and Bioinformatics Department, Lomonosov Moscow State FEBS J. 2008 Oct;275(20):4990-5006. Epub 2008 Sep 9.
DOI Direct Link
Changes in ECG and enzyme activity in rat heart after myocardial infarction: effect of TPP and MnCl2.
Heart infarction is one of the main causes of death in the human...
17th December, 2008
Department of Animal Biochemistry, Institute of Biology, University of J Physiol Biochem. 2008 Jun;64(2):93-101.
Structural bases for the specific interactions between the E2 and E3 components of the Thermus thermophilus 2-oxo acid dehydrogenase complexes.
Pyruvate dehydrogenase (PDH), branched-chain 2-oxo acid dehydrogenase...
1st October, 2008
RIKEN SPring-8 Center, Harima Institute, Sayo, Hyogo 679-5148, Japan. J Biochem. 2008 Jun;143(6):747-58. Epub 2008 Mar 3.
DOI Direct Link
Exclusion of OGDH and BMP4 as candidate genes in two siblings with autosomal recessive DOOR syndrome.
Pyruvate dehydrogenase (PDH), branched-chain 2-oxo acid dehydrogenase...
4th October, 2007
Department of Medical Genetics, University Hospital Antwerp, Edegem, Am J Med Genet A. 2007 Apr 1;143(7):763-7.
DOI Direct Link

View more research publications.

Clinical Trials:

Clinical Trials Logo
Brain Energy Metabolism in Patients With Chronic Liver Disease and Impaired Central Nervous System

Patents:

Patents logo
US Patent No.Title
7598031 Method for the detection of gene transcripts in blood and uses thereof
6613506 Compositions and methods for inhibiting human immunodeficiency virus infection by down-regulating human cellular genes
6828150 Antigen presenting system and methods for activation of T-cells
7208313 Combined growth factor-deleted and thymidine kinase-deleted vaccinia virus vector
7226761 Manufacture of five-carbon sugars and sugar alcohols

View more patents.

OGDH results (if any) from reagent suppliers

Google CSE Logo
α-KGD (C-20) Antibody sc-49589
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, OGDH, 4967, 7p13, NM_001003941, ...
http://www.scbt.com/datasheet-49589-alpha-kgd-c-20-antibody....

Thumbshot
α-KGD (C-20) Antibody sc-49589
Humain, OGDH, 4967, 7p13, NM_001003941, NM_002541 · Q02218 · 203740. Souris, Ogdh, 18293, 11 A1, Q60597, Non disponible ...
http://www.scbt.com/fr/datasheet-49589-alpha-kgd-c-20-antibo...

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α-KGD (D-14) Antibody sc-49590
种属, 基因名称, 基因ID, 染色质位置, 亚型(mRNA)即位号码, 蛋白质即位号码, OMIM™ 号码. 人类, OGDH, 4967, 7p13, NM_001003941, NM_002541 · Q02218 ...
http://www.scbt.com/zh/datasheet-49590-alpha-kgd-d-14-antibo...

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α-KGD (E-15) Antibody sc-49591
Species, Nome del gene, Codice del gene, Locus cromosoma, Isoform (mRNA) Accession #, codice accesso proteina, Numero d' ordine. Human, OGDH, 4967, 7p13
...
http://www.scbt.com/it/datasheet-49591-alpha-kgd-e-15-antibo...

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