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OLR1


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Gene DB Home
Symbol:OLR1
Name(s):oxidized low density lipoprotein (lectin-like) receptor 1
Type:protein-coding
Organism:Homo sapiens
Synonyms:CLEC8A, LOX1, SCARE1
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18054331 CC genotype of OLR-1 G501C polymorphism is associated with susceptibility and serum C-reactive protein concentration in Chinese essential hypertensive population
18220661 This review summarizes recent advances related to the role of LOX-1 in atherosclerosis.
12384789 Observational study of gene-disease association. (HuGE Navigator)
12646194 Observational study of gene-disease association. (HuGE Navigator)
12807963 Observational study of gene-disease association. (HuGE Navigator)
15562935 Observational study of gene-disease association. (HuGE Navigator)
15860461 Observational study of gene-disease association. (HuGE Navigator)
16013913 Observational study of gene-disease association. (HuGE Navigator)
16251892 Observational study of gene-disease association. (HuGE Navigator)
16328515 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)

View more information from publications.

Recent Publications on OLR1:

Pubmed Logo
Dyslipidemia-induced neuropathy in mice: the role of oxLDL/LOX-1.
OBJECTIVE: Neuropathy is a frequent and severe complication of diabetes....
24th October, 2009
Department of Neurology, University of Michigan, Ann Arbor, Michigan, USA. Diabetes. 2009 Oct;58(10):2376-85. Epub 2009 Jul 10.
DOI Direct Link
Deletion of LOX-1 attenuates renal injury following angiotensin II infusion.
Angiotensin II upregulates the expression of LOX-1, a recently identified...
23rd October, 2009
Department of Medicine, University of Arkansas for Medical Sciences and Kidney Int. 2009 Sep;76(5):521-7. Epub 2009 Jun 24.
DOI Direct Link
Evidence for increased methylglyoxal in the vasculature of women with preeclampsia: role in upregulation of LOX-1 and arginase.
Preeclampsia is characterized by vascular endothelial dysfunction partly...
21st October, 2009
Department of Physiology, University of Alberta, Edmonton, Alberta, Hypertension. 2009 Oct;54(4):897-904. Epub 2009 Aug 17.
DOI Direct Link
Oligomerization is required for the activity of recombinant soluble LOX-1.
LOX-1 is a scavenger receptor that functions as the primary receptor for...
15th October, 2009
Department of Biological Technologies, Wyeth Research, Cambridge, MA FEBS J. 2009 Sep;276(17):4909-20. Epub 2009 Jul 31.
DOI Direct Link
Scavenger receptors of endothelial cells mediate the uptake and cellular proatherogenic effects of carbamylated LDL.
OBJECTIVE: Carbamylated LDL (cLDL) has been recently shown to have robust...
30th September, 2009
Department of Pharmacology & Toxicology, University of Arkansas for Arterioscler Thromb Vasc Biol. 2009 Oct;29(10):1622-30. Epub 2009 Aug 20.
DOI Direct Link

View more research publications.

Clinical Trials:

Clinical Trials Logo
Molecular Targeting of 15-Lipoxygenase-1 (15-LOX-1) for Apoptosis Induction in Human Colorectal Cancers

Patents:

Patents logo
US Patent No.Title
7547687 Therapeutic treatment methods
4306265 Power interruption protection system for electric motors
6756228 Atherosclerosis susceptibility gene locus 1 (Athsq1) and atherosclerosis susceptibility gene locus 2 (Athsq2)
6905827 Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases
7026121 Methods and compositions for diagnosing and monitoring transplant rejection

View more patents.

OLR1 results (if any) from reagent suppliers

Google CSE Logo
Monoclonal Anti-mouse LOX-1/OLR1-Phycoerythrin
(OLR-1), is a type II transmembrane receptor belonging to the C-type lectin family.1 It also belongs to the functionally defined ...
http://www.rndsystems.com/pdf/FAB1564P.pdf...

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OLR1/LOX1, Clone 23C11, Human mAb
OLR1/LOX1, Clone 23C11, Human mAb. Description: The monoclonal antibody 23C11 reacts with lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1). ...
http://www.cellsciences.com/PDF/HM2138.pdf...

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Ox-LDL R-1 (H-140) Antibody sc-20753
In vivo and in vitro studies support that a new splicing isoform of OLR1 gene is protective against acute myocardial infarction. Circ Res. 97(2): 152-158. ...
http://www.scbt.com/datasheet-20753-ox-ldl-r-1-h-140-antibod...

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FITC CONJUGATED MONOCLONAL ANTIBODY TO HUMAN LOX-1
SCARE1, CLEC8A, OLR1. Species. Mouse IgG1. Formulation. 1 ml (100 µg/ml) 0.2 µm filtered FITC conjugated antibody solution in PBS, containing 1% bovine ...
http://www.hbt.nl/HM2138F.pdf...

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Ox-LDL R-1 (Y-21) Antibody sc-11653
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Mouse, Olr1, 108078, 6 F3, Q9EQ09 ...
http://www.scbt.com/datasheet-11653-ox-ldl-r-1-y-21-antibody...

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MONOCLONAL ANTIBODY TO HUMAN LOX-1
SCARE1, CLEC8A, OLR1. Species. Mouse IgG1. Formulation. 1 ml (100 µg/ml) 0.2 µm filtered antibody solution in PBS, containing 0.1% bovine serum albumin. ...
http://www.hbt.nl/HM2138.pdf...

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Ox-LDL R-1 (E-19) Antibody sc-11650
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, OLR1, 4973, 12p13.2, NM_002543 ...
http://www.scbt.com/datasheet-11650-ox-ldl-r-1-e-19-antibody...

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