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ORC2L
Gene Information from Publications |
| Publication Link |
Summary of findings |
| 11779870 |
ORC2 physically interacts with ORC1 on non-chromatin nuclear structures |
| 15910003 |
Study using HCT116 haplo-insufficient cells and Orc2 hypomorphic cells demonstrates that human Ku80 and Orc2 bind to replication origins independently of each other. |
| 16407251 |
The low level of Orc2 in Orc2 hypomorphic cells hinders normal cell cycle progression by delaying the activation of G1 cyclin-dependent kinases. |
| 12912926 |
The precise nucleotide of binding for ORC2 was identified near the stgart site for leading-strand synthesis; the transition to the post-replicative complex is accompanied by a 17 bp displacement of ORC2 towards the start site. |
| 12897055 |
the human origin recognition complex has a role in sequence-independent DNA binding and replication initiation |
| 16762929 |
human Orc2 has specific domains that are required in vivo for assembly and nuclear localization of the origin recognition complex |
Interacting gene products |
| Interaction Type |
Gene 1 |
Gene 2 |
Interaction description |
Complex |
Publication Link |
| HPRD | CDC6 | origin recognition complex, subunit 2 | - | - | Pubmed |
| HPRD | cell division cycle 6 protein | ORC2 | - | - | Pubmed |
| HPRD | cyclin-dependent kinase 2 isoform 1 | origin recognition complex, subunit 2 | - | - | Pubmed |
| BIND | Homo sapiens chromosome 11, reference assembly. | origin recognition complex, subunit 2 | Orc2 interacts with beta-globin origin. | - | Pubmed |
| HPRD | Minichromosome maintenance protein 2 | origin recognition complex, subunit 2 | - | - | Pubmed |
| HPRD | minichromosome maintenance complex component 2 | ORC2 | - | - | Pubmed |
| HPRD | MCM7 | origin recognition complex, subunit 2 | - | - | Pubmed |
| HPRD | minichromosome maintenance complex component 7 isoform 1 | Origin recognition complex subunit 2 | - | - | Pubmed |
| BIND | Homo sapiens chromosome 8, reference assembly. | origin recognition complex, subunit 2 | Ocr2 interacts with C-Myc origin. | - | Pubmed |
| HPRD | origin recognition complex, subunit 1 | origin recognition complex, subunit 2 | - | - | Pubmed |
Recent Publications on ORC2L: |  |
Gene expression profiles in liver of mouse after chronic exposure to drinking water.
cDNA micorarray approach was applied to hepatic transcriptional profile... | 16th May, 2009
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| J Appl Toxicol. 2009 Oct;29(7):569-77.
DOI Direct Link |
Global analysis of metastasis-associated gene expression in primary cultures from clinical specimens of clear-cell renal-cell carcinoma.
Metastatic clear-cell renal-cell carcinoma (ccRCC) has a poor prognosis... | 19th July, 2008
| Department of Epidemiology, Second Military Medical University, Shanghai,
| Int J Cancer. 2008 Sep 1;123(5):1080-8.
DOI Direct Link |
Interactions and subcellular distribution of DNA replication initiation proteins in eukaryotic cells.
For initiation of eukaryotic DNA replication the origin recognition... | 26th January, 2008
| Department of Biochemistry, University of Wurzburg, Biozentrum, Am
| Mol Genet Genomics. 2007 Dec;278(6):623-32. Epub 2007 Aug 7.
DOI Direct Link |
ATP-dependent assembly of the human origin recognition complex.
The origin recognition complex (ORC) was initially discovered in budding... | 14th December, 2007
| Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA.
| J Biol Chem. 2007 Nov 2;282(44):32370-83. Epub 2007 Aug 22.
DOI Direct Link |
Acute reduction of an origin recognition complex (ORC) subunit in human cells reveals a requirement of ORC for Cdk2 activation.
The origin recognition complex (ORC) is involved in formation of... | 24th September, 2005
| Department of Biochemistry and Molecular Genetics, University of Virginia
| J Biol Chem. 2005 Jul 29;280(30):27624-30. Epub 2005 Jun 7.
DOI Direct Link |
→View more research publications. |
ORC2L results (if any) from reagent suppliers | 
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Orc2 antibody [3G6] (ab22537) | Abcam
ORC2L is a subunit of the ORC complex. ORC2L forms a core complex with ORC3L ... ORC2L specifically associate with the origin of replication of Epstein Barr ...
http://www.abcam.com/Orc2-antibody-3G6-ab22537.html...
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ORC2 (H-300) Antibody sc-28742
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, ORC2L, 4999, 2q33.1, NM_006190 ...
http://www.scbt.com/datasheet-28742-orc2-h-300-antibody.html...
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3C-3E
Monoclonal Anti-ORC2L antibody produced in mouse clone 3E11-1G5, purified immunoglobulin, buffered aqueous solution, 3E11-1G5 (monoclonal) ...
http://www.sigmaaldrich.com/etc/controller/controller-page.h...
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ORC2 (H-300) Antibody sc-28742
Humano, ORC2L, 4999, 2q33.1, NM_006190 · Q13416 · 601182. Ratón, Orc2l, 18393, 1 C1.3, Q60862, No Aplicable. Información sobre pedidos ...
http://www.scbt.com/es/datasheet-28742-orc2-h-300-antibody.h...
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Western Blot Image Gallery
Western blot detection of ORC2L in Jurkat lysate using PA1-9075. SPP1. Western blot detection of SPP1 in human thymus lysate using PA1-9076. ...
http://www.bioreagents.com/products/productLists/westernBlot...
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