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P2RX1


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Symbol:P2RX1
Name(s):purinergic receptor P2X, ligand-gated ion channel, 1
Type:protein-coding
Organism:Homo sapiens
Synonyms:P2X1
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17399929 P2X1 mRNA expression may occur as a result of an increased component of neural ATP release in the aging bladder.
12521992 plays a role in hemostasis and thrombosis through its participation in collagen-, thromboxane A(2)-, and shear stress-triggered platelet responses
14699168 residues Lys-68, Phe-185, Phe-291, Arg-292, and Lys-309 contribute to ligand binding at P2X(1) receptors, with Phe-185 and Phe-291 coordinating the binding of the adenine ring of ATP
16420578 P2X(1) and ERK2 both participate in shear stress controlled thrombosis, but ERK2 activation is initiated predominantly via GPIb-VWF interactions.
14675100 P2X1 stimulation can induce/potentiate platelet activation in combination with other platelet agonists
15686781 P2X1 receptors are expressed in human cardiomyocytes and mainly distributed in the regions of intercalated discs; there is some close association of P2X1 receptors and connexin43 in some, not all, regions.
16359770 P2X receptor-mediated contractions of human pregnant uterus to alpha,beta-meATP and EFS, but not to ATP, are increased with the progression of pregnancy
11816716 P2X1 ion channel acts as a positive regulator of platelet responses to collagen.
12239162 Mediates activation of extracellular signal-regulated kinase 2 and contributes to platelet secretion and aggregation induced by collagen
16236030 glycine 250 substitution by serine gave functional responses to ATP with no effect on ATP sensitivity but a reduction in peak amplitude to P2X1 receptors

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDPurinergic receptor P2X ligand gated ion channel 1purinergic receptor P2X2 isoform D--Pubmed

Recent Publications on P2RX1:

Pubmed Logo
Smooth muscle and purinergic contraction of the human, rabbit, rat, and mouse testicular capsule.
The smooth-muscle cells of the testicular capsule (tunica albuginea) of...
11th November, 2005
Autonomic Neuroscience Centre, Royal Free Hospital, London NW3 2PF, United Biol Reprod. 2006 Mar;74(3):473-80. Epub 2005 Nov 9.
DOI Direct Link

Patents:

Patents logo
US Patent No.Title
6706867 DNA array sequence selection
6673908 Tumor necrosis factor receptor 2
6406853 Interventions to mimic the effects of calorie restriction

P2RX1 results (if any) from reagent suppliers

Google CSE Logo
CHO PhotoScreen™ P2RX1 Cell Line from PerkinElmer - USA
The kit contains two vials of cryopreserved CHO PhotoScreen P2RX1 cells. The technical data sheet includes detailed cell line information as well as culture
...
http://las.perkinelmer.com/Catalog/ProductInfoPage.htm?Produ...

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Antibodies to P2X Receptors
P2rx1(25505) human ... P2RX1(5023), human, rat, IHC (p), WB CL, pricing. P7982, Anti-P2X2 Purinergic Receptor antibody produced in rabbit, (polyclonal) ...
https://www.sigmaaldrich.com/etc/controller/controller-page....

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P2X1 (Y-14) Antibody sc-31491
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, P2RX1, 5023, 17p13.2, NM_002558 ...
http://www.scbt.com/datasheet-31491-p2x1-y-14-antibody.html...

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P1-PC
AV35105, Anti-P2RX1 antibody produced in rabbit, (polyclonal), IgG fraction of antiserum ... human ... P2RX1(5023), human, rat, IHC (p), WB CL, pricing ...
http://www.sigmaaldrich.com/etc/controller/controller-page.h...

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P2X1 (H-100) Antibody sc-25692
Humano, P2RX1, 5023, 17p13.2, NM_002558 · P51575 · 600845. camundongo, P2rx1, 18436, 11 B4, P51576, N/A. Informacoes sobre ordens ...
http://www.scbt.com/pt/datasheet-25692-p2x1-h-100-antibody.h...

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S2671 Suramin sodium salt ≥95%
assay, ≥95%. solubility, H2O: >10 mg/mL. Gene Information, human ... EGF(1950), P2RX1(5023), P2RY1(5028), PDGFA(5154), PLD1(5337) ...
http://www.sigmaaldrich.com/catalog/ProductDetail.do?N4=S267...

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P2X1 (H-100) Antibody sc-25692
Humain, P2RX1, 5023, 17p13.2, NM_002558 · P51575 · 600845. Souris, P2rx1, 18436, 11 B4, P51576, Non disponible. Produits disponibles ...
http://www.scbt.com/fr/datasheet-25692-p2x1-h-100-antibody.h...

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