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P2RX3


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Symbol:P2RX3
Name(s):purinergic receptor P2X, ligand-gated ion channel, 3
Type:protein-coding
Organism:Homo sapiens
Synonyms:MGC129956, P2X3
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
15475563 negative residues in the P2X3 ATP receptor ectodomain are structural determinants for desensitization and the Ca2+-sensing modulatory sites
17052768 These data indicate that PKC activation can enhance both the Ca(2+) signal as well as the cation current through P2X(3)R, however it appears that the regulation is unlikely to be a result of direct phosphorylation of the receptor.
14520770 in fibers of human tooth pulp ... may play a role in perception of dental pain
12885270 Review. Activation of P2X(3)-containing channels is an important mediator of persistent nociceptive signalling. The data also indicate potential discrete roles for homomeric P2X(3) & heteromeric P2X(2/3) receptor activation in acute & chronic pain.
15331767 Effect of acute hypoxia on cloned homo- and heteromeric P2X3 receptors expressed in human embryonic kidney 293 cells.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDPurinergic receptor P2X ligand gated ion channel 3purinergic receptor P2X2 isoform D--Pubmed

Recent Publications on P2RX3:

Pubmed Logo
Ectodermal P2X receptor function plays a pivotal role in craniofacial development of the zebrafish.
P2X receptors are non-selective cation channels operated by extracellular...
17th June, 2009
Department of Pharmacological and Physiological Science, Saint Louis Purinergic Signal. 2009 Sep;5(3):395-407. Epub 2009 Jun 16.
DOI Direct Link
Comparative expression of p2x receptors and ecto-nucleoside triphosphate diphosphohydrolase 3 in hypocretin and sensory neurons in zebrafish.
The hypocretin/orexin (HCRT/ORX) excitatory neuropeptides are expressed in...
11th March, 2008
Department of Psychiatry and Behavioral Sciences, Stanford University, Brain Res. 2007 Oct 12;1174:66-75. Epub 2007 Aug 9.
DOI Direct Link
Selective labeling of central and peripheral sensory neurons in the developing zebrafish using P2X(3) receptor subunit transgenes.
The two paralogous P2X receptor subunit genes p2rx3.1 and p2rx3.2 are...
17th August, 2006
Department of Pharmacological and Physiological Science, Saint Louis Neuroscience. 2006;138(2):641-52. Epub 2006 Jan 18.
DOI Direct Link

Patents:

Patents logo
US Patent No.Title
7588771 Microorganisms for therapy
7588767 Microorganisms for therapy
7208313 Combined growth factor-deleted and thymidine kinase-deleted vaccinia virus vector
6673908 Tumor necrosis factor receptor 2

P2RX3 results (if any) from reagent suppliers

Google CSE Logo
P2X3 antibody (ab10269) | Abcam
P2RX3 is a member of the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and transduces ATP-evoked nociceptor a..
.
http://www.abcam.com/P2X3-antibody-ab10269.html...

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Anti- Purinergic Receptor P2X3 (P0121) - Data Sheet
Anti- Purinergic Receptor P2X3 recognizes rat P2rx3. (gene ID: 81739). ... P2rx3 (gene ID: 228139 ). In human 13 out of 15 residues are identical. ...
http://www.sigmaaldrich.com/etc/medialib/docs/Sigma/Datashee...

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P2X3 (H-60) Antibody sc-25694
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, P2RX3, 5024, 11q12.1, NM_002559 ...
http://www.scbt.com/ko/datasheet-25694-p2x3-h-60-antibody.ht...

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P1-PC
affinity isolated antibody, mouse ... P2rx3(228139) human ... P2RX3(5024) rat .. . P2rx3(81739), rat, mouse, human, IF (i), IHC, WB, pricing ...
http://www.sigmaaldrich.com/etc/controller/controller-page.h...

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P2X3 (A-16) Antibody sc-12215
Species, 遺伝子名, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. ヒト, P2RX3, 5024, 11q12.1, NM_002559 ...
http://www.scbt.com/ja/datasheet-12215-p2x3-a-16-antibody.ht...

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P2X3 (A-16) Antibody sc-12215
Humain, P2RX3, 5024, 11q12.1, NM_002559 · P56373 · 600843. Souris, P2rx3, 228139 , 2 D, Q3UR32, Non disponible. Produits disponibles ...
http://www.scbt.com/fr/datasheet-12215-p2x3-a-16-antibody.ht...

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P2X3 (H-60) Antibody sc-25694
Humano, P2RX3, 5024, 11q12.1, NM_002559 · P56373 · 600843. Ratón, P2rx3, 228139, 2 D, Q3UR32, No Aplicable. Información sobre pedidos ...
http://www.scbt.com/es/datasheet-25694-p2x3-h-60-antibody.ht...

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