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P2RX4


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Symbol:P2RX4
Name(s):purinergic receptor P2X, ligand-gated ion channel, 4
Type:protein-coding
Organism:Homo sapiens
Synonyms:P2X4, P2X4R
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
15167446 Observational study of gene-disease association. (HuGE Navigator)
17197037 Observational study of gene-disease association. (HuGE Navigator)
17895406 This review discusses the need to reinterpret the assumed "go-it alone" function of the P2X7 receptor in light of convincing biochemical and electrophysiological evidence for the existence of P2X4/P2X7 heteromeric receptors.
15130891 Increased contractility likely underlies survival benefit from P2X4 receptor overexpression.
15006691 We have identified a distinct subpopulation of P2X4-positive macrophages infiltrating the dystrophic fibres. These cells were absent from normal muscle and rarely present in the dystrophic muscle taken before and after the onset of degeneration.
17264311 Main role for P2X(4) receptor in nucleotide-induced apoptosis in human mesangial cells, indicating a relevant role for purinergic signaling in regulating death rate in these cells.
15262999 in human parotid acinar cells, in addition to modulation of Ca(2+) release, Ca(2+) influx through P2X(4)R may constitute a further locus for the synergistic effects of Ca(2+) and PKA activation.
12088286 Results show that P2X4 and P2X6 receptors are associated with VE-cadherin at HUVEC adherens junctions.
12714321 shear stress stimulates pulmonary artery endothelial cells to release ATP, which activates Ca2+ influx via P2X4 receptors.
16533808 wild-type desensitization properties requires an aromatic moiety at position 374 and an amino rather than a guanidino group at position 373

View more information from publications.

Recent Publications on P2RX4:

Pubmed Logo
Behavioral phenotypes of mice lacking purinergic P2X4 receptors in acute and chronic pain assays.
A growing body of evidence indicates that P2X receptors (P2XRs), a family...
16th September, 2009
Department of Molecular and System Pharmacology, Graduate School of Mol Pain. 2009 Jun 11;5:28.
DOI Direct Link
Association of polymorphisms in P2RX7 and CaMKKb with anxiety disorders.
BACKGROUND: There is considerable evidence that genetic factors play an...
19th August, 2007
Max Planck Institute of Psychiatry, Kraepelinstr. 2-10, D-80804 Munchen, J Affect Disord. 2007 Aug;101(1-3):159-68. Epub 2007 Jan 2.
DOI Direct Link
Regulation of neuronal type genes in congestive heart failure rats.
AIM: After myocardial infarction (MI), complex changes in the heart occur...
16th September, 2006
Institute for Experimental Medical Research, Ullevaal University Hospital, Acta Physiol (Oxf). 2006 Jan;186(1):17-27.
DOI Direct Link
Linkage and potential association of obesity-related phenotypes with two genes on chromosome 12q24 in a female dizygous twin cohort.
Obesity is a multifactorial disorder with a complex phenotype. It is a...
26th May, 2006
Department of Endocrinology & Diabetes, Sir Charles Gairdner Hospital, Eur J Hum Genet. 2006 Mar;14(3):340-8.
DOI Direct Link
Impaired flow-dependent control of vascular tone and remodeling in P2X4-deficient mice.
The structure and function of blood vessels adapt to environmental changes...
28th February, 2006
Department of Biomedical Engineering, Graduate School of Medicine, Nat Med. 2006 Jan;12(1):133-7. Epub 2005 Dec 4.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
7598031 Method for the detection of gene transcripts in blood and uses thereof
6905827 Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases
7026121 Methods and compositions for diagnosing and monitoring transplant rejection
7205146 Nucleotide and amino acid sequences relating to respiratory diseases and obesity
7208313 Combined growth factor-deleted and thymidine kinase-deleted vaccinia virus vector

View more patents.

P2RX4 results (if any) from reagent suppliers

Google CSE Logo
P2RX4 antibodies: Cardiovascular > Blood > Blood Pressure ...
P2RX4 antibodies. ... Applications (see key) & Reactivity (see key). Image Abreview Publication. ab50319 · P2RX4 antibody. WB. Rabbit polyclonal ...
http://www.abcam.com/index.html?t=203289&pt=1&c=4432&ei=&mu=...

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P2X4 (N-15) Antibody sc-15187
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIMâ„¢ Number. Human, P2RX4, 5025, 12q24.31, NM_002560 ...
http://www.scbt.com/datasheet-15187-p2x4-n-15-antibody.html...

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All P2X Receptors | Abcam
P2RX4 antibody. WB. Rabbit polyclonal ... P2RX4 antibody. WB, ELISA. Goat polyclonal ... P2RX4 antibody. IHC-P, WB, IHC-Fr. Rabbit polyclonal ...
http://www.abcam.com/index.html?c=464...

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Antibodies to P2X Receptors
P2rx4(29659), rat, IHC (p), WB CL, pricing. P8232, Anti-P2X7 Purinergic Receptor antibody produced in rabbit, (polyclonal), affinity isolated antibody ...
https://www.sigmaaldrich.com/etc/controller/controller-page....

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P1-PC
rat ... P2rx4(29659), rat, IHC (p), WB CL, pricing ... human ... P2RX4(5025), rat, canine, human, bovine, mouse, ELISA (i), WB, pricing ...
http://www.sigmaaldrich.com/etc/controller/controller-page.h...

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P2X4 (N-15) Antibody sc-15187
Humain, P2RX4, 5025, 12q24.31, NM_002560 · Q99571 · 600846. Souris, P2rx4, 18438 , 5 F, Q9JJX6, Non disponible. Produits disponibles ...
http://www.scbt.com/fr/datasheet-15187-p2x4-n-15-antibody.ht...

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Abcam antibodies and reagents product map
... Natriuretic Peptide Receptor C antibodies (2) · Natriuretic Peptide Receptor C proteins and peptides (2) · P2RX4 antibodies (3) · PER2 antibodies (3) ...
http://www.abcam.com/index.html?c=253...

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