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P2RX7


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Symbol:P2RX7
Name(s):purinergic receptor P2X, ligand-gated ion channel, 7
Type:protein-coding
Organism:Homo sapiens
Synonyms:MGC20089, P2X7
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18268501 Observational study of gene-disease association. (HuGE Navigator)
18089587 a novel P2X7 purinoceptor inflammatory pathway may be involved in the release of interleukin-1 beta, which may be linked to the onset of labor.
12404161 Observational study of gene-disease association. (HuGE Navigator)
12493261 Observational study of gene-disease association. (HuGE Navigator)
12931211 Observational study of gene-disease association. (HuGE Navigator)
14510944 Observational study of gene-disease association. (HuGE Navigator)
15089763 Observational study of gene-disease association. (HuGE Navigator)
15184265 Observational study and meta-analysis of gene-disease association. (HuGE Navigator)
15862308 Observational study of genotype prevalence. (HuGE Navigator)
16321858 Observational study of gene-disease association. (HuGE Navigator)

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDActin betapurinergic receptor P2X7--Pubmed
HPRDbeta actinPurinergic receptor P2X, ligand gated ion channel, 7--Pubmed
HPRDpurinergic receptor P2X7supervillin isoform 2--Pubmed

Recent Publications on P2RX7:

Pubmed Logo
Pathways in external apical root resorption associated with orthodontia.
To review studies investigating if genetic factors play a role in external...
30th October, 2009
Department of Oral Health Science, University of Kentucky College of Orthod Craniofac Res. 2009 Aug;12(3):236-42.
DOI Direct Link
Purinergic P2X7 receptors regulate secretion of interleukin-1 receptor antagonist and beta cell function and survival.
AIMS/HYPOTHESIS: In obesity, beta cells activate compensatory mechanisms...
24th October, 2009
Department of Medicine, Larry L. Hillblom Islet Research Center, UCLA, Los Diabetologia. 2009 Aug;52(8):1579-88. Epub 2009 Apr 25.
DOI Direct Link
A functional P2X7 splice variant with an alternative transmembrane domain 1 escapes gene inactivation in P2X7 knock-out mice.
The ATP-activated P2X7 receptor channel is involved in immune function and...
20th October, 2009
Department of Neurochemistry, Max Planck Institute (MPI) for Brain J Biol Chem. 2009 Sep 18;284(38):25813-22. Epub 2009 Jun 22.
DOI Direct Link
Synopsis and synthesis of candidate-gene association studies in chronic lymphocytic leukemia: the CUMAGAS-CLL information system.
A comprehensive and systematic assessment of the current status of...
24th September, 2009
Department of Biomathematics, University of Thessaly School of Medicine, Am J Epidemiol. 2009 Sep 15;170(6):671-8. Epub 2009 Aug 21.
DOI Direct Link
Activation of the NLRP3 inflammasome in dendritic cells induces IL-1beta-dependent adaptive immunity against tumors.
The therapeutic efficacy of anticancer chemotherapies may depend on...
22nd September, 2009
Institut National de la Sante et de la Recherche Medicale, U805, Nat Med. 2009 Oct;15(10):1170-8. Epub 2009 Sep 20.
DOI Direct Link

View more research publications.

BioNews Results for P2RX7

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Activation of the NLRP3 inflammasome in dendritic cells induces IL-1EUR'dependent adaptive immunity against t
Nature:  Oct 9 2009 3:46PM Matching: p2rx7

Patents:

Patents logo
US Patent No.Title
7612181 Dual variable domain immunoglobulin and uses thereof
7598031 Method for the detection of gene transcripts in blood and uses thereof
7560243 White blood cell functional assay
7547687 Therapeutic treatment methods
7482334 Therapeutic treatment methods

View more patents.

P2RX7 results (if any) from reagent suppliers

Google CSE Logo
Antibodies to P2X Receptors
P2RX7(5027) rat ... P2rx7(29665) mouse ... P2rx7(18439), rat, human, mouse, FACS , pricing. P0120, Anti-Purinergic Receptor P2Y13 antibody produced in rabbit ...
https://www.sigmaaldrich.com/etc/controller/controller-page....

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P8232 Anti-P2X7 Purinergic Receptor antibody produced in rabbit ...
Gene Information, human ... P2RX7(5027). rat ... P2rx7(29665). mouse ... P2rx7( 18439). shipped in, dry ice. storage temp. −20°C ...
http://www.sigmaaldrich.com/catalog/ProductDetail.do?N4=P823...

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All P2X Receptors | Abcam
P2RX7 antibody. IHC-P, WB, ELISA. Images. Rabbit polyclonal ... P2RX7 antibody - C-terminal. IHC-P, WB, IHC-Fr. Rabbit polyclonal ...
http://www.abcam.com/index.html?c=464...

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P2X7 (G-20) Antibody sc-31500
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, P2RX7, 5027, 12q24.31, NM_002562 ...
http://www.scbt.com/datasheet-31500-p2x7-g-20-antibody.html...

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Antibodies to Neurotransmitter Receptors
P2RX7(5027), rat, mouse, human, WB, pricing. P1231, Anti-P2Y4 Purinergic Receptor antibody produced in rabbit, (polyclonal), affinity isolated antibody
...
http://www.sigmaaldrich.com/etc/controller/controller-page.h...

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P2X7 (G-20) Antibody sc-31500
Spezies, Gen, Gen ID, Chromosomaler Locus, mRNA (Isoform) Accession #, Protein Accession #, OMIM™ Nummer. Human, P2RX7, 5027, 12q24.31, NM_002562 · Q99572 ...
http://www.scbt.com/de/datasheet-31500-p2x7-g-20-antibody.ht...

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Cayman Chemical | KN-62 | Description (CAS 127191-97-3)
2 KN-62 also acts as a non-competitive antagonist of the purinergic receptor P2RX7 (IC50 = 15 nM). 3. 1 Tokunitsu, H., Chijiwa, T., Hagiwara, M., et al. ...
http://www.caymanchem.com/app/template/Product.vm/catalog/13...

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