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P2RY1


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Symbol:P2RY1
Name(s):purinergic receptor P2Y, G-protein coupled, 1
Type:protein-coding
Organism:Homo sapiens
Synonyms:P2Y1
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18057028 These results highlight a role of P2Y(1)R in EGFR-dependent epithelial cell proliferation. P2Y(1)R could potentially mediate both trophic stimuli of basally released nucleotides and first-line mitogenic stimulation upon tissue damage.
15514209 Observational study of gene-disease association. (HuGE Navigator)
16581111 Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator)
17559347 Observational study of gene-disease association and pharmacogenomic / toxicogenomic. (HuGE Navigator)
17559347 Presence of the P2Y1 893CC genotype appears to confer an attenuated antiplatelet effect during aspirin treatment in healthy Chinese volunteers.
17824841 oligomerization of the P2Y11 receptor with the P2Y1 receptor controls the internalization and ligand selectivity of the P2Y11 receptor
14644082 Supports P2Y(12) as a drug target compared with P2Y(1).
15203713 both P2Y12 and P2Y1 contribute to ADP-potentiation of platelet-derived microparticles generation induced by collagen
17095747 To determine if polymorphisms in P2X7 are associated with increased risk of TB. The 1513C allele increases susceptibility to extrapulmonary TB.
12787128 Different purinergic receptors have different functional roles in human epidermis with P2Y1 and P2Y2 receptors controlling proliferation, while P2X5 and P2X7 receptors control early differentiation, terminal differentiation and death of keratinocytes.

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDAdenosine A1 receptorpurinergic receptor P2Y1--Pubmed
HPRDadenosine A1 receptorPurinoceptor P2Y1--Pubmed
HPRDpurinergic receptor P2Y1solute carrier family 9, isoform 3 regulator 1--Pubmed
HPRDpurinergic receptor P2Y1solute carrier family 9, isoform 3 regulator 1--Pubmed
BINDpurinergic receptor P2Y1solute carrier family 9, isoform 3 regulator 1NHERF interacts with P2Y1R.-Pubmed
HPRDpurinergic receptor P2Y1solute carrier family 9 isoform 3 regulator 2--Pubmed
HPRDpurinergic receptor P2Y1solute carrier family 9 isoform 3 regulator 2--Pubmed

Recent Publications on P2RY1:

Pubmed Logo
Ticagrelor yields consistent dose-dependent inhibition of ADP-induced platelet aggregation in patients with atherosclerotic disease regardless of genotypic variations in P2RY12, P2RY1, and ITGB3.
The platelet P2Y(12) receptor is the target of clopidogrel therapy, which...
29th October, 2009
Cardiovascular Research Unit, University of Sheffield, Sheffield, UK. Platelets. 2009 Aug;20(5):341-8.
DOI Direct Link
Genetics of Platelet Reactivity in Normal, Healthy Individuals.
Summary Background: The Platelet Function Analyzer-100 (PFA-100) is widely...
11th September, 2009
Department of Molecular and Experimental Medicine, The Scripps Research J Thromb Haemost. 2009 Sep 9.
DOI Direct Link
Lack of association between aspirin responsiveness and seven candidate gene haplotypes in patients with symptomatic vascular disease.
We studied the effect of prophylactic aspirin (ASA) ingestion on platelet...
28th February, 2009
Department of Molecular and Experimental Medicine, The Scripps Research Thromb Haemost. 2009 Jan;101(1):123-33.
Expression analysis of G Protein-Coupled Receptors in mouse macrophages.
ABSTRACT: BACKGROUND: Monocytes and macrophages express an extensive...
30th April, 2008
Cooperative Research Centre for Chronic Inflammatory Diseases and Special Immunome Res. 2008 Apr 29;4(1):5.
DOI Direct Link
Nucleotide P2Y1 receptor regulates EGF receptor mitogenic signaling and expression in epithelial cells.
Epidermal growth factor receptor (EGFR) function is transregulated by a...
18th March, 2008
Centro de Regulacion Celular y Patologia JV Luco, Facultad de Ciencias J Cell Sci. 2007 Dec 15;120(Pt 24):4289-301.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
7588771 Microorganisms for therapy
7588767 Microorganisms for therapy
7208313 Combined growth factor-deleted and thymidine kinase-deleted vaccinia virus vector
7186812 Isolated human G-protein coupled receptors, nucleic acid molecules encoding human GPCR proteins, and uses thereof

P2RY1 results (if any) from reagent suppliers

Google CSE Logo
P2Y1 (H-120) Antibody sc-20123
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, P2RY1, 5028, 3q25.2, NM_002563 ...
http://www.scbt.com/datasheet-20123-p2y1-h-120-antibody.html...

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P1-PC
HPA015577, Anti-P2RY1 antibody produced in rabbit, (polyclonal), affinity isolated antibody, human ... P2RY1(5028), human, IHC (p), PA, WB, pricing ...
http://www.sigmaaldrich.com/etc/controller/controller-page.h...

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Antibodies to Neurotransmitter Receptors
rat ... P2ry1(25265) human ... P2RY1(5028), rat, human, IHC, WB, pricing. P4871, Anti-Purinergic Receptor P2Y12 antibody produced in rabbit, (polyclonal) ...
https://www.sigmaaldrich.com/etc/controller/controller-page....

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P2Y1 (H-120) Antibody sc-20123
... Numéro d'accès de la protéine, Numéro OMIM™. Humain, P2RY1, 5028, 3q25.2, NM_002563 · P47900 · 601167. Souris, P2ry1, 18441, 3 D, P49650, Non disponible
...
http://www.scbt.com/fr/datasheet-20123-p2y1-h-120-antibody.h...

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BIOMOL International - Purinergic Receptor Antibodies
+, Ubiquitons and Zomes (Ubiquitin and Proteasome). +, Special Purpose Biochemicals. Purinergic Receptor Antibodies. Anti-P2Y1 (P2RY1) · Anti-P2Y2 (
P2RY2) ...
http://www.biomol.com/?pageId=36&categoryId=965...

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P2Y1 (A-15) Antibody sc-15204
Species, 遺伝子名, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. ヒト, P2RY1, 5028, 3q25.2, NM_002563 ...
http://www.scbt.com/ja/datasheet-15204-p2y1-a-15-antibody.ht...

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BIOMOL International - P2Y Receptors
+, Bioactive Lipids. +, Neuroscience. +, Ubiquitons and Zomes (Ubiquitin and Proteasome). +, Special Purpose Biochemicals. P2Y Receptors. Anti-P2Y1 (P2RY1)
...
http://www.biomol.com/Online_Catalog/Online_Catalog/Products...

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