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P4HA1
| Symbol: | P4HA1 | | Name(s): | procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide I | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | 4-PH alpha-1, P4HA | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 16837461 |
Results suggest that the alteration of translational efficiency by nucleolin, which occurs through a hypoxia inducible factor independent pathway, is an important step in collagen prolyl 4-hydroxylase-alpha(I) regulation under hypoxia. |
| 16877351 |
In comparison with healthy cartilage, Osteoarthritis articular chondrocytes exhibit increased in vivo synthesis of collagen prolyl-4-hydroxylase type II, a pivotal enzyme in collagen triple helix formation. |
| 15369792 |
These in vivo data demonstrated that smokers had thinner atherosclerotic cap thickness and lower levels of P4Halpha and collagen. |
| 16464861 |
Collagen prolyl 4-hydroxylase-alpha (I)mRNA is stabilized by interation of RNA-binding proteins hnRNP-A2/B1 with a U(16) element within the 3'-UTR |
| 16885164 |
HIF-P4H, HIF-1alpha and HIF-2alpha are effective oxygen sensors |
| 16488890 |
positive (transforming growth factor beta1) and negative (cigarette smoking extract) regulators appear to influence the USF-E-box interaction and affect P4Halpha(I) expression |
Recent Publications on P4HA1: |  |
Hepatic gene expression in morbidly obese women: implications for disease susceptibility.
The objective of this study was to determine the molecular bases of... | 9th October, 2009
| Department of Medicine and Research Service, Veterans Affairs Medical
| Obesity (Silver Spring). 2009 Aug;17(8):1563-73. Epub 2009 Mar 5.
DOI Direct Link |
Cellular oxygen sensing: Importins and exportins are mediators of intracellular localisation of prolyl-4-hydroxylases PHD1 and PHD2.
Hypoxia-inducible factors are crucial in the regulatory process of oxygen... | 27th August, 2009
| Department of Physiology, Center for Structural and Cell Biology in
| Biochem Biophys Res Commun. 2009 Oct 2;387(4):705-11. Epub 2009 Jul 23.
DOI Direct Link |
Variations within oxygen-regulated gene expression in humans.
The effects of hypoxia on gene transcription are mainly mediated by a... | 20th February, 2009
| Dept. of Physiology, University of Oxford, Oxford OX1 3PT, UK.
| J Appl Physiol. 2009 Jan;106(1):212-20. Epub 2008 Nov 13.
DOI Direct Link |
Differential gene expression associated with postnatal equine articular cartilage maturation.
BACKGROUND: Articular cartilage undergoes an important maturation process... | 27th January, 2009
| University of Kentucky, Department of Veterinary Science, M.H. Gluck
| BMC Musculoskelet Disord. 2008 Nov 5;9:149.
DOI Direct Link |
Role of NonO-histone interaction in TNFalpha-suppressed prolyl-4-hydroxylase alpha1.
Inflammation is a key process in cardiovascular diseases. The... | 2nd August, 2008
| Division of Cardiovascular Surgery, the Texas Heart Institute at St.
| Biochim Biophys Acta. 2008 Aug;1783(8):1517-28. Epub 2008 Mar 29.
DOI Direct Link |
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