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PA2G4


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Symbol:PA2G4
Name(s):proliferation-associated 2G4, 38kDa
Type:protein-coding
Organism:Homo sapiens
Synonyms:EBP1, HG4-1, p38-2G4
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17951246 B23 distinctively binds Ebp1 isoforms and regulates cell proliferation and survival through p42 and p48, respectively.
17765895 The structure provides insights in how Ebp1 discriminates between its different interaction partners.
17768350 ErbB-3-binding protein 1 (Ebp1) is a member of the family of proliferation-associated 2G4 proteins (PA2G4s) and plays a role in cellular growth and differentiation.
17641068 ErbB-3-binding protein-1 is an immunogenic protein with cancer-related immunoreactivity, capable of eliciting CD8-positive T cell-mediated responses in vivo and in vitro.
15064750 EBP1 is in the cytoplasm & nucleolus. Nucleolar localization requires AA sequences at the NH2- and COOH-ends. Overexpression inhibits proliferation of human fibroblasts. It is part of RNP complexes & associates with different rRNAs.
15994225 Ebp1 suppresses androgen receptor-mediated gene transcription and tumorigenesis of prostate cancer cells.
15583694 These studies suggest that Ebp1 is an AR corepressor whose biological activity can be regulated by the ErbB3 ligand, HRG.
16396631 Ebp1 is present in protein-ARE(bcl-2) RNA complexes. Ebp1 & nucleolin are present in the same bcl-2 mRNP complexes. Ebp1 decreases the rate of decay of beta-globin-ARE(bcl-2) transcripts. Ebp1 contributes to bcl-2 expression regulation in HL-60 cells.
16631606 Our results demonstrate that Ebp1 is a new dsRNA-binding protein that acts as a cellular inhibitor of eIF2alpha phosphorylation suggesting that it could be involved in protein translation control
17295834 over-expression of Ebp1 interfered with virus production

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDandrogen receptor isoform 1proliferation-associated 2G4, 38kDa--Pubmed
HPRDv-erb-b2 erythroblastic leukemia viral oncogene homolog 3proliferation-associated 2G4, 38kDa--Pubmed
HPRDv-erb-b2 erythroblastic leukemia viral oncogene homolog 3proliferation-associated 2G4, 38kDa--Pubmed
BINDv-erb-b2 erythroblastic leukemia viral oncogene homolog 3proliferation-associated 2G4, 38kDaErbB-3 interacts with EBP1.-Pubmed
HPRDhistone deacetylase 2proliferation-associated 2G4, 38kDa--Pubmed
HPRDhistone deacetylase 2proliferation-associated 2G4, 38kDa--Pubmed
BINDhistone deacetylase 2proliferation-associated 2G4, 38kDaHDAC2 interacts with Ebp1-Pubmed
HPRDPA2G4retinoblastoma 1--Pubmed
HPRDproliferation-associated 2G4, 38kDaRetinoblastoma 1--Pubmed
HPRDproliferation-associated 2G4, 38kDaexosome component Rrp46--Pubmed

Recent Publications on PA2G4:

Pubmed Logo
Molecular-assisted immunohistochemical optimization.
Immunohistochemistry (IHC) is an essential tool in diagnostic surgical...
25th July, 2009
Oncology Research Institute, National University of Singapore, Singapore; Acta Histochem. 2009 Jul 21.
DOI Direct Link
Quantitative mass spectrometry identifies drug targets in cancer stem cell-containing side population.
A multifaceted approach is presented as a general strategy to identify new...
12th June, 2009
The Skaggs Institute for Chemical Biology and Department of Chemistry and Stem Cells. 2008 Dec;26(12):3037-46. Epub 2008 Sep 18.
DOI Direct Link
Human BRE1 is an E3 ubiquitin ligase for Ebp1 tumor suppressor.
Human Bre1, an E3 ligase for H2B monoubiquitination, binds p53 and...
11th April, 2009
Department of Pathology and Laboratory Medicine, Emory University School Mol Biol Cell. 2009 Feb;20(3):757-68. Epub 2008 Nov 26.
DOI Direct Link
Alterations in cell growth and signaling in ErbB3 binding protein-1 (Ebp1) deficient mice.
BACKGROUND: The ErbB3 binding protein-1 (Ebp1) belongs to a family of...
19th March, 2009
Department of Pathology, University of Maryland School of Medicine, BMC Cell Biol. 2008 Dec 18;9:69.
DOI Direct Link
Riboproteomic analysis of polypeptides interacting with the internal ribosome-entry site element of foot-and-mouth disease viral RNA.
Initiation of translation driven by internal ribosome entry site (IRES)...
14th January, 2009
Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Proteomics. 2008 Nov;8(22):4782-90.
DOI Direct Link

View more research publications.

Clinical Trials:

Clinical Trials Logo
Erlotinib and RAD001 (Everolimus) in Patients With Previously Treated Advanced Pancreatic Cancer

Patents:

Patents logo
US Patent No.Title
7588771 Microorganisms for therapy
7588767 Microorganisms for therapy
7579434 Peptide having ability to activate cancer-related gene
7495147 Neuregulin-1 transgenic mouse and methods of use
7235358 Methods and compositions for diagnosing and monitoring transplant rejection

View more patents.

PA2G4 results (if any) from reagent suppliers

Google CSE Logo
P1-PC
HPA016484, Anti-PA2G4 antibody produced in rabbit, (polyclonal), affinity isolated antibody, human ... PA2G4(5036), human, IHC (p), PA, WB, pricing ...
http://www.sigmaaldrich.com/etc/controller/controller-page.h...

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Abgent - Stem Cell
AP2002b, Osteocalcin Antibody (C-term), IHC, E, H. AP2002a, Osteocalcin Antibody (N-term), WB, IHC, E, H. AP2848cNEW, PA2G4 Antibody (Center P205), WB, E, H ...
http://www.abgent.com/products/category/stem_cell...

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EBP1 (T-21) Antibody sc-133531
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, PA2G4, 5036, 12q13.2, Q9UQ80 ...
http://www.scbt.com/ko/datasheet-133531-ebp1-t-21-antibody.h...

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EBP1 Antibody (C-term)
Proliferation-associated protein 2G4; Cell cycle protein p38-2G4 homolog; hG4-1; ErbB3-binding protein 1; PA2G4; EBP1. Application Data: Calculated MW: ...
http://www.abgent.com/products/catalog_no/AP2848b_EBP1_Antib...

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EBP1 (T-21) Antibody sc-133531
人类, PA2G4, 5036, 12q13.2, Q9UQ80 · 602145. 小鼠, Pa2g4, 18813, 10 D3, P50580, N/A. 订购信息. 产品名称, 产品编号, 规格, 价格, 数量, 欲购列单 ...
http://www.scbt.com/zh/datasheet-133531-ebp1-t-21-antibody.h...

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Mar05_denovo_No prices.qxd
PA2G4. Suppressor of Ty16 Homolog. SUPT16H. TABLE 2. The M24 family. R&D Systems ' aminopeptidases are all purified from mammalian cells that express the ...
http://www.rndsystems.com/DAM_public/5317.pdf...

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EBP1 (T-21) Antibody sc-133531
... Numero de Accesion de la Proteina, Número de pedido: Humano, PA2G4, 5036, 12q13.2, Q9UQ80 · 602145. Ratón, Pa2g4, 18813, 10 D3, P50580, No Aplicable ...
http://www.scbt.com/es/datasheet-133531-ebp1-t-21-antibody.h...

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