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FURIN


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Symbol:FURIN
Name(s):furin (paired basic amino acid cleaving enzyme)
Type:protein-coding
Organism:Homo sapiens
Synonyms:FUR, PACE, PCSK3, SPC1
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17948127 Data suggest that furin levels in cystic fibrosis respiratory epithelial cells contributes to bacterial toxin-induced cell death, fibrosis, and local immunosuppression.
17938254 s-HJV originates from a furin cleavage at position 332-335
18037384 These data support the hypothesis of a direct binding of heparin with site1 and site2, allowing selective exposure/accessibility of the REKR sequence, which is only then optimally cleaved by furin.
17905608 HEPC MISSENSE MUTATION CAUSING INEFFICIENT CLEAVAGE INDICATES THAT THE FURIN BINDING SITE BE MORE THAN 4 RESIDUES
17905609 the hepatic prohormone convertase furin mediates the posttranslational processing of hepcidin. The proteolytic cleavage of prohepcidin to hepcidin is not regulated by iron-transferrin or the HIF pathway
17641413 Furin may constitute a marker for ovarian tumor progression and could contribute to predict the outcome of this disease.
17909005 ppFurin expression in breast cancer cells decreased MMP-9 activity, but had no significant effect on TIMP-1 secretion.
17477394 This study provides valuable insights into the structural properties of the furin prodomain in relation to its role in the folding of the furin zymogen and its inhibitory action toward furin.
17360815 Furin P1A promoter undergoes transactivation via Sox9 binding during chondrogenesis.
14644155 findings established the existence of a novel alternative/complementary pathway by which furin increases tumor cell invasion through an amplification/activation loop between MMP-2 and TGFbeta

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDAP2M1furin preproprotein--Pubmed
HPRDadaptor-related protein complex 2, mu 1 subunit isoform aFurin--Pubmed
HPRDFilamin Afurin preproprotein--Pubmed
HPRDfilamin 1Furin--Pubmed
HPRDgamma filaminfurin preproprotein--Pubmed
HPRDgamma filaminfurin preproprotein--Pubmed
HPRDLow density lipoprotein receptor-related protein 1furin preproprotein--Pubmed
HPRDlow density lipoprotein-related protein 1Furin--Pubmed
HPRDfurin preproproteinserine proteinase inhibitor, clade B, member 8--Pubmed
HPRDfurin preproproteinserine proteinase inhibitor, clade B, member 8--Pubmed

Recent Publications on FURIN:

Pubmed Logo
Cell-surface processing of the metalloprotease pro-ADAMTS9 is influenced by the chaperone GRP94/GP96.
A Disintegrin-like And Metalloprotease domain with Thrombospondin type 1...
31st October, 2009
Cleveland Clinic, United States. J Biol Chem. 2009 Oct 29.
DOI Direct Link
Role of L2 cysteines in papillomavirus infection and neutralization.
ABSTRACT: Vaccination of mice with minor capsid protein L2 or passive...
29th October, 2009
Virol J. 2009 Oct 27;6(1):176.
DOI Direct Link
Human testicular orphan receptor 4 enhances thyroid hormone receptor signaling.
The thyroid hormone receptor (TR) and human testicular orphan receptor 4...
28th October, 2009
Department of Biochemistry, School of Medicine, Chang-Gung University, J Cell Physiol. 2009 Oct 26.
DOI Direct Link
Alternative mechanism of activation of the epithelial Na+ channel by cleavage.
We examined activation of the human epithelial sodium channel (ENaC) by...
28th October, 2009
Univ. Buffalo, United States; J Biol Chem. 2009 Oct 26.
DOI Direct Link
The proprotein convertase furin in human trophoblast: Possible role in promoting trophoblast cell migration and invasion.
Furin, a proprotein convertase (PC), is ubiquitously expressed and...
27th October, 2009
State Key Laboratory of Reproductive Biology, Institute of Zoology, Placenta. 2009 Nov;30(11):929-38. Epub 2009 Oct 22.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
7538091 Intracellular delivery of biological effectors
7563760 P-selectin ligand protein
7566565 PC5 as a factor IX propeptide processing enzyme
7569391 Method for making .beta.-secretase co-crystals complexed with a ligand
7569544 Methods of increasing delivery of active agents to brain comprising administering receptor associated protein (RAP) fragments conjugated to active agents

View more patents.

FURIN results (if any) from reagent suppliers

Google CSE Logo
Furin Antibody / Furin Antibodies
Furin Antibody / Furin Antibodies. ... Furin specific siRNA, sHRNA Plasmid and shRNA Lentiviral Particles gene silencers are also available. ...
http://www.scbt.com/table-furin.html...

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Furin antibody (ab3467) | Abcam
Rabbit polyclonal to Furin. Furin is a membrane-associated, calcium-dependent, serine protease that belongs to the subtilisin-like prohormone convertase ...
http://www.abcam.com/Furin-Convertase-antibody-ab3467.html...

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Furin (H-220) Antibody sc-20801
See how others have used Furin (H-220): sc-20801 antibody and or Furin (H-220) antibody ... Sorting of Furin in Polarized Epithelial and Endothelial Cells: ...
http://www.scbt.com/datasheet-20801-furin-h-220-antibody.htm...

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ADAMTS6 antibody - First furin cleavage site of the propeptide ...
Rabbit polyclonal to ADAMTS6 - First furin cleavage site of the propeptide domain. ADAMTS6 was first described along with ADAMTS5 and ADAMTS7 in database
...
http://www.abcam.com/ADAMTS6-antibody-First-furin-cleavage-s...

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Furin(P8077), Proteases, NEB
Furin is a ubiquitous subtilisin-like proprotein convertase. It is the major processing enzyme of the secretory pathway and is localized in the trans-golgi
...
http://www.neb.com/nebecomm/products/productP8077.asp...

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ADAMTS9 antibody - Between first and second furin site (ab28277 ...
Rabbit polyclonal to ADAMTS9 - Between first and second furin site. ADAMTS proteases are secreted enzymes containing a prometalloprotease domain of the ...
http://www.abcam.com/ADAMTS9-antibody-Between-first-and-seco...

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Human Furin MAb (Clone 222722)
Furin is a type I transmembrane serine protease of the proprotein convertase family. ... Furin has an essential role in embryogenesis and homeostasis and is
...
http://www.rndsystems.com/pdf/MAB1503.pdf...

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