Gene Information from Publications |
| Publication Link |
Summary of findings |
| 17948127 |
Data suggest that furin levels in cystic fibrosis respiratory epithelial cells contributes to bacterial toxin-induced cell death, fibrosis, and local immunosuppression. |
| 17938254 |
s-HJV originates from a furin cleavage at position 332-335 |
| 18037384 |
These data support the hypothesis of a direct binding of heparin with site1 and site2, allowing selective exposure/accessibility of the REKR sequence, which is only then optimally cleaved by furin. |
| 17905608 |
HEPC MISSENSE MUTATION CAUSING INEFFICIENT CLEAVAGE INDICATES THAT THE FURIN BINDING SITE BE MORE THAN 4 RESIDUES |
| 17905609 |
the hepatic prohormone convertase furin mediates the posttranslational processing of hepcidin. The proteolytic cleavage of prohepcidin to hepcidin is not regulated by iron-transferrin or the HIF pathway |
| 17641413 |
Furin may constitute a marker for ovarian tumor progression and could contribute to predict the outcome of this disease. |
| 17909005 |
ppFurin expression in breast cancer cells decreased MMP-9 activity, but had no significant effect on TIMP-1 secretion. |
| 17477394 |
This study provides valuable insights into the structural properties of the furin prodomain in relation to its role in the folding of the furin zymogen and its inhibitory action toward furin. |
| 17360815 |
Furin P1A promoter undergoes transactivation via Sox9 binding during chondrogenesis. |
| 14644155 |
findings established the existence of a novel alternative/complementary pathway by which furin increases tumor cell invasion through an amplification/activation loop between MMP-2 and TGFbeta |
| 15564468 |
releases Feline foamy virus (FFV) Env leader protein (Elp)from ENV precursor protein. |
| 16627761 |
IL-12 caused Furin to be preferentially expressed in differentiated Th1 cells in a Stat4-dependent manner |
| 12736257 |
furin has a role in processing human pro-CNP |
| 16912035 |
PCSK9 levels are finely regulated by the basic amino acid convertases furin and PC5/6A |
| 15637056 |
furin can directly cleave the RXXR amino acid sequence in the propeptide domain of proMMP-2 leading to inactivation of the enzyme. |
| 15611046 |
Analysis of furin promoters revealed the presence of putative binding sites for HIF-1; hypoxic/HIF-1 regulation of furin correlated with increased proteolytic activation of substrates MMP1 and TFGbeta1. |
| 15371436 |
HIV-1 gp160 processing by furin is inhibited by polyarginine |
| 12584323 |
role in Semliki Forest virus p62 processing |
| 15659365 |
serpin/furin complex stability depends on pH and regulation at the deacylation step |
| 16407210 |
an amino acid substitution in the PC1/3 propeptide can induce significant modifications of its inhibitory profile toward furin |
| 11861638 |
Furin proteolytically processes the heparin-binding region of extracellular superoxide dismutase |
| 15584904 |
HGF and BCL-2 family proteins use a furin-dependent pathway to promote invasion via TGF-beta and MMP in human malignant glioma cells and the pro-invasive properties of TGF-beta require furin- dependent MMP activity. |
| 15911696 |
furin and PC5 play a role in a MT-MMP-MMP-2 proteolytic cascade, involving provision of macrophage MT1-MMP for the activation of pro-MMP-2; furin and PC5 are expressed in monocytes and colocalize with MT1-MMP in macrophages in the atherosclerotic plaque |
| 12411321 |
involvement of the proximal GATA recognition motif in the P1 promoter and impact on the maturation of furin substrates of Furin gene regulation in differentiating megakaryoblastic cells. |
| 12547702 |
Increased activity of this enzyme enhances the malignant phenotype of human head and neck cancer cells. |
| 15606899 |
From a brain cDNA library of possible interacting proteins, furin efficiently processes both the beta-secretase beta-amyloid protein converting enzyme pro-BACE1 and its novel interacting partner brain-specific type II membrane protein pro-BRI3. |
| 14596804 |
Data suggest that mutations that diminish domain 2 Ca(2+) binding allow furin access to an otherwise protected cleavage site, initiating the proteolytic cascade that leads to gelsolin amyloidogenesis and familial amyloidosis of Finnish type. |
| 11723118 |
we investigated the specificity and potency of complete prodomains and short C-terminal prodomain peptides of each SPC on highly purified, soluble enzyme preparations of human SPC1, SPC6, and SPC7. |
| 12220680 |
results show that shedding of furin occurs rapidly and further suggest that specific cysteine residues may impart a conformation to the enzyme, thereby affecting its susceptibility to proteolysis |
| 16648485 |
Furin mediates cleavage of a receptor tyrosine phosphatase and regulation of beta catenin's transcriptional activity. |
| 15240540 |
furin is responsible for VEGF-C processing in human oral tongue squamous cell carcinoma progression |
| 17283058 |
These findings highlight a pivotal role for furin, MT1-MMP, and MMP2 in TNF-alpha-induced sphingolipid signaling, and they identify this system as a possible target to inhibit SMC proliferation in vascular diseases. |
| 14739277 |
furin is a novel chemokine-modifying enzyme in vitro and most probably also in vivo, generating a C-terminally truncated CXCL10, which fully retains its (inverse) agonistic properties. |
| 14741044 |
modelling of furin's pro-region revealed that Ile-60 and His-66 might be crucial in forming the binding interface with the catalytic domain, while residues Trp-34 and Phe-67 might be involved in maintaining a hydrophobic core within the pro-region itself |
| 15247425 |
Results report the identification of Spn4A, a previously uncharacterized secretory pathway serine protease inhibitor (serpin) from Drosophila melanogaster that contains a consensus furin cleavage site. |
| 16537537 |
pro-ADAMTS9 is processed at the cell surface by furin |
| 16942750 |
furin enhances alpha-secretase activity via the cleavage of ADAM10 and TACE, and attenuated furin activity is connected to the production of Abeta |
