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PAK1
| Symbol: | PAK1 | | Name(s): | p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast) | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | MGC130000, MGC130001, PAKalpha | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 14607331 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17981134 |
Rac1/Pak1/LIMK1 signaling pathway controls cofilin activity within the lamellipodium. |
| 17911169 |
study reports that elevated (alpha6)beta4 integrin-dependent Rac-Pak1 signaling supports resistance to apoptosis in mammary acini by permitting stress-dependent activation of the p65 subunit of NF-kappaB through Pak1 |
| 18006851 |
16k PRL inhibits cell migration by blocking the Ras-Tiam1-Rac1-Pak1 signaling pathway in endothelial cells |
| 17486065 |
Amplification of PAK1 is associated with recurrence and tamoxifen resistance in postmenopausal breast cancer |
| 17621631 |
point to Pak1 as an exciting target for therapy of renal cancer, which remains highly refractory to existing treatments |
| 17018616 |
TGF-ss, via PI3K, recruits the actin cytoskeleton to HER2, which colocalizes with Vav2, activated Rac1, & its effector Pak1 at lamellipodia, leading to prolonged Rac1 activation, enhanced cell motility & survival. Dominant-negative Pak1 abrogates this. |
| 17609315 |
we present a model for Pak1 signaling that provides a mechanism for specifically affecting cardiac cellular processes--REVIEW |
| 17491012 |
ESE-1 functions are coordinately regulated by Pak1 phosphorylation and beta-TrCP-dependent ubiquitin-proteasome pathways. |
| 16800003 |
Phosphorylation of caldesmon by PAK is a dynamic process required to regulate actin dynamics and membrane protrusions in wound-induced cell migration. | →View more information from publications. |
Recent Publications on PAK1: |  |
Mutant polycystin-2 induces proliferation in primary rat tubular epithelial cells in a STAT-1/p21-independent fashion accompanied instead by alterations in expression of p57KIP2 and Cdk2.
BACKGROUND: Autosomal Dominant Polycystic Kidney Disease (ADPKD) is... | 28th October, 2008
| Department of Biological Sciences, University of Cyprus, Cyprus.
| BMC Nephrol. 2008 Aug 25;9:10.
DOI Direct Link |
Urokinase (uPA) mediates endothelial cell survival via induction of the X-linked inhibitor of apoptosis protein (XIAP).
The fibrinolytic system was originally implicated to assist the angiogenic... | 25th October, 2008
| Clinical Division of Oncology, Department of Medicine I and Cancer Center,
| Blood. 2008 Oct 23.
DOI Direct Link |
PAK1-mediated activation of ERK1/2 regulates lamellipodial dynamics.
PAK1 is a member of the p21-activated kinase (PAK) family of... | 23rd October, 2008
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| J Cell Sci. 2008 Oct 21.
DOI Direct Link |
Scaffolding function of PAK in the PDK1-Akt pathway.
Many extracellular signals stimulate phosphatidylinositol-3-kinase, which... | 22nd October, 2008
| [1] Institute of Molecular and Cellular Biosciences, University of Tokyo,
| Nat Cell Biol. 2008 Nov;10(11):1356-64. Epub 2008 Oct 19.
DOI Direct Link |
Expression of Active p21-Activated Kinase-1 (Pak1) Induces Ca2+-flux Modification with Altered Regulatory Protein Phosphorylation in Cardiac Myocytes.
P21 activated kinase-1 (Pak1) is a serine-threonine kinase, which... | 17th October, 2008
| University of Illinois at Chicago.
| Am J Physiol Cell Physiol. 2008 Oct 15.
DOI Direct Link |
→View more research publications. |
PAK1 results (if any) from reagent suppliers | 
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PAK1 Antibody #2602
PAK1 Antibody detects endogenous levels of total PAK1 protein. It does not cross -react with PAK2, PAK3 or other PAK family members. ...
http://www.cellsignal.com/products/2602.html...
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PAK1 antibody (ab1178) datasheet | Abcam
Rabbit polyclonal to PAK1. The serine/threonine kinase Pak1 is an effector of small Rho GTPases, Rac1 and Cdc42. Pak1 complex specifically with Rac1 and ...
http://www.abcam.com/PAK1-antibody-ab1178.html...
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Phospho-PAK1 (Thr423)/PAK2 (Thr402) Antibody #2601
Western blot analysis of extracts from guinea pig neutrophils stimulated with 1 µM fMLP for indicated times, using Phospho-PAK1 (Thr423)/PAK2 (Thr402) ...
http://www.cellsignal.com/products/2601.html...
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Pak1 Antibody / Pak1 Antibodies
Pak1 Antibody / Pak1 Antibodies. ... Pak1 (yC-18) Antibody, sc-31685, goat IgG, C-terminus (Sc), WB, IF, ELISA, S. cerevisiae. Pak1 (yD-16) Antibody ...
http://www.scbt.com/table-pak1.html...
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Phospho-PAK1 (Ser144)/PAK2 (Ser141) Antibody #2606
Western blot analysis of extracts from guinea pig neutrophils stimulated with fMLP for indicated times, using Phospho-PAK1 (Ser144)/PAK2 (Ser141) Antibody ...
http://www.cellsignal.com/products/2606.html...
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PAK1 antibody, PAK1 (Phospho-Thr212) Antibody, Rabbit IgG ...
Buy quality rabbit PAK1 antibody (interacts with human mouse rat), anti-PAK1, PAK1 (Phospho-Thr212) antibody, rabbit igg polyclonal antibody, ...
http://www.genwaybio.com/product_info.php?products_id=210349...
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PAK1/2/3 Antibody #2604
PAK1/2/3 Antibody detects endogenous levels of PAK1, PAK2 and PAK3 protein. The antibody does not react with PAK4, PAK5 or PAK6. ...
http://www.cellsignal.com/products/2604.html...
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PAK1 Antibody (N-term)
Abgent develops powerful tools to profile posttranslational modifications related to cellular function and disease. Abgent antibodies target protein
kinases ...
http://www.abgent.com/products/catalog_no/AP7926a/background...
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PAK1 + PAK2 + PAK3 (phospho S141) antibody (ab5247) datasheet | Abcam
Rabbit polyclonal to PAK1 + PAK2 + PAK3 (phospho S141). In mammals, there are several identified isoforms of p21 Activated Protein Kinases or PAKs: PAK1 and
...
http://www.abcam.com/index.html?datasheet=5247...
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Pak1 (yN-19) Antibody sc-31683
See how others have used Pak1 (yN-19): sc-31683 and or Pak1 (yN-19) antibody ... PAK1 hyperactivation is sufficient for mammary gland tumor formation. ...
http://www.scbt.com/datasheet-31683-pak1-yn-19-antibody.html...
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