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PAK1
| Symbol: | PAK1 | | Name(s): | p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast) | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | MGC130000, MGC130001, PAKalpha | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 14607331 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17981134 |
Rac1/Pak1/LIMK1 signaling pathway controls cofilin activity within the lamellipodium. |
| 17911169 |
study reports that elevated (alpha6)beta4 integrin-dependent Rac-Pak1 signaling supports resistance to apoptosis in mammary acini by permitting stress-dependent activation of the p65 subunit of NF-kappaB through Pak1 |
| 18006851 |
16k PRL inhibits cell migration by blocking the Ras-Tiam1-Rac1-Pak1 signaling pathway in endothelial cells |
| 17486065 |
Amplification of PAK1 is associated with recurrence and tamoxifen resistance in postmenopausal breast cancer |
| 17621631 |
point to Pak1 as an exciting target for therapy of renal cancer, which remains highly refractory to existing treatments |
| 17018616 |
TGF-ss, via PI3K, recruits the actin cytoskeleton to HER2, which colocalizes with Vav2, activated Rac1, & its effector Pak1 at lamellipodia, leading to prolonged Rac1 activation, enhanced cell motility & survival. Dominant-negative Pak1 abrogates this. |
| 17609315 |
we present a model for Pak1 signaling that provides a mechanism for specifically affecting cardiac cellular processes--REVIEW |
| 17491012 |
ESE-1 functions are coordinately regulated by Pak1 phosphorylation and beta-TrCP-dependent ubiquitin-proteasome pathways. |
| 16800003 |
Phosphorylation of caldesmon by PAK is a dynamic process required to regulate actin dynamics and membrane protrusions in wound-induced cell migration. | →View more information from publications. |
Recent Publications on PAK1: |  |
Differential expression and phosphorylation of Pak1 and Pak2 in ovarian cancer: Effects on prognosis and cell invasion.
Ovarian cancer is a gynecological malignancy of high mortality.... | 31st October, 2009
| Department of Pathology and The University of Hong Kong, Queen Mary
| Int J Cancer. 2009 Oct 28.
DOI Direct Link |
FTY720 prevents ischemia/reperfusion injury-associated arrhythmias in an ex vivo rat heart model via activation of Pak1/Akt signaling.
Recent studies demonstrated a role of sphingosine-1-phosphate (S1P) in the... | 27th October, 2009
| Cardiovascular Research Group, School of Clinical and Laboratory Sciences,
| J Mol Cell Cardiol. 2009 Oct 21.
DOI Direct Link |
The Rho Guanosine 5'-Triphosphatase, Cell Division Cycle 42, Is Required for Insulin-Induced Actin Remodeling and Glucagon-Like Peptide-1 Secretion in the Intestinal Endocrine L Cell.
Rho GTPases, such as cell division cycle 42 (Cdc42) and ras-related C3... | 13th October, 2009
| Departments of Physiology (G.E.L., M.X., T.J., P.L.B.), Laboratory
| Endocrinology. 2009 Oct 9.
DOI Direct Link |
CHL1 cooperates with PAK1-3 to regulate morphological differentiation of embyronic cortical neurons.
The cell adhesion molecule close homologue of L1 (CHL1) is important for... | 13th October, 2009
| Department of Biochemistry and Biophysics, School of Medicine, The
| Neuroscience. 2009 Oct 9.
DOI Direct Link |
Role of p47phox in Regulating Cdc42GAP, Vimentin, and Contraction in Smooth Muscle Cells.
Cdc42GAP (GTPase activating protein) has been shown to regulate smooth... | 9th October, 2009
| 1Albany Medical College.
| Am J Physiol Cell Physiol. 2009 Oct 7.
DOI Direct Link |
→View more research publications. |
PAK1 results (if any) from reagent suppliers | 
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PAK1 Antibody #2602
Western blot analysis of extracts from HeLa cells transfected with 100 nM control siRNA #6201 (-) or PAK1 siRNA, using PAK1 Antibody #2602 and p42 MAP ...
http://www.cellsignal.com/products/2602.html...
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PAK1 antibody (ab1178) | Abcam
Rabbit polyclonal to PAK1. The serine/threonine kinase Pak1 is an effector of small Rho GTPases, Rac1 and Cdc42. Pak1 complex specifically with Rac1 and ...
http://www.abcam.com/PAK1-antibody-ab1178.html...
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Phospho-PAK1 (Thr423)/PAK2 (Thr402) Antibody #2601
Western blot analysis of extracts from guinea pig neutrophils stimulated with 1 µM fMLP for indicated times, using Phospho-PAK1 (Thr423)/PAK2 (Thr402) ...
http://www.cellsignal.com/products/2601.html...
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PAK1 antibody, PAK1 (Phospho-Thr212) Antibody, Rabbit Polyclonal ...
Buy quality rabbit PAK1 antibody (interacts with human mouse rat), anti-PAK1, PAK1 (Phospho-Thr212) antibody, rabbit polyclonal antibody, ...
http://www.genwaybio.com/product_info.php?products_id=210349...
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Phospho-PAK1 (Ser144)/PAK2 (Ser141) Antibody #2606
Western blot analysis of extracts from guinea pig neutrophils stimulated with fMLP for indicated times, using Phospho-PAK1 (Ser144)/PAK2 (Ser141) Antibody ...
http://www.cellsignal.com/products/2606.html...
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PAK1 + PAK2 + PAK3 (phospho T423) antibody (ab2477) | Abcam
Rabbit polyclonal to PAK1 + PAK2 + PAK3 (phospho T423). In mammals, there are several identified isoforms of p21 Activated Protein Kinases or PAKs: PAK1 and
...
http://www.abcam.com/PAK1-PAK2-PAK3-phospho-T423-antibody-ab...
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PAK 1/2/3 Antibody Sampler Kit #4750
The PAK antibody sampler kit provides and economical means to evaluate the activation status of PAK1, 2, and 3. This kit includes enough primary and ...
http://www.cellsignal.com/products/4750.html...
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