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PAK2
Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18176785 |
protein phosphatase 1alpha can act directly on phosphorylated Thr-402 in the activation loop of PAK2 and down-regulate its kinase activity |
| 17881449 |
interaction of Nef with PAK2 does not play a major role in T-cell activation, viral replication, and apoptosis. |
| 14749374 |
Pak2 phosphorylates Myc at three sites (T358, S373, and T400) and affects Myc functions both in vitro and in vivo |
| 16281055 |
Pak2 binds to and phosphorylates initiation factor eIF4G, which inhibits association of eIF4E with m7GTP, reducing translation initiation. |
| 16204230 |
binding of Cdc42 localizes Pak2 to the endoplasmic reticulum, where autophosphorylation alters association of the two proteins |
| 15234964 |
Pak2 has a role in the down-regulation of translation initiation in apoptosis by phosphorylation of Mnk1 |
| 12823590 |
The opposing effects of Core protein on the transcription pf P21 might be important in the progression of liver disease in HCV-positive patients. |
| 12453877 |
Cdc42/Rac1-dependent activation of PAK may trigger early platelet shape change, at least in part through the regulation of cortactin binding to PAK. |
| 16867995 |
c-Abl represents a target downstream of phosphatidylinositol 3-kinase-activated PAK2, which differentiates TGF-beta signaling in fibroblasts and epithelial cell lines. |
| 16979207 |
This study of tissue-derived HIV-1 Nefs demonstrates that CD4 and MHC-I downregulation are highly conserved Nef functions, while Pak2 association is variable in late stage AIDS patients. | →View more information from publications. |
Recent Publications on PAK2: |  |
Differential expression and phosphorylation of Pak1 and Pak2 in ovarian cancer: Effects on prognosis and cell invasion.
Ovarian cancer is a gynecological malignancy of high mortality.... | 31st October, 2009
| Department of Pathology and The University of Hong Kong, Queen Mary
| Int J Cancer. 2009 Oct 28.
DOI Direct Link |
Activated actin-depolymerizing factor/cofilin sequesters phosphorylated microtubule-associated protein during the assembly of alzheimer-like neuritic cytoskeletal striations.
In Alzheimer's disease (AD), rod-like cofilin aggregates (cofilin-actin... | 31st October, 2009
| The Brain & Mind Research Institute, and Bosch Institute, School of
| J Neurosci. 2009 Oct 14;29(41):12994-3005.
DOI Direct Link |
Non-Canonical TGF{beta}-Pathways, mTORC1 and Abl, in Renal Interstitial Fibrogenesis.
Renal interstitial fibrosis is a major determinant of renal failure in the... | 23rd October, 2009
| Los Angeles Biomedical Research Institute.
| Am J Physiol Renal Physiol. 2009 Oct 21.
DOI Direct Link |
ER-localized bestrophin 1 activates Ca(2+)-dependent ion channels TMEM16A and SK4 possibly by acting as a counterion channel.
Bestrophins form Ca(2+)-activated Cl(-) channels and regulate... | 14th October, 2009
| Institut fur Physiologie, Universitat Regensburg, Universitatsstrasse 31,
| Pflugers Arch. 2009 Oct 13.
DOI Direct Link |
HIV-1 Nef interferes with host cell motility by deregulation of Cofilin.
HIV-1 Nef is a key factor in AIDS pathogenesis. Here, we report that Nef... | 10th October, 2009
| Department of Virology, Im Neuenheimer Feld 324, University of Heidelberg,
| Cell Host Microbe. 2009 Aug 20;6(2):174-86.
DOI Direct Link |
→View more research publications. |
PAK2 results (if any) from reagent suppliers | 
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