Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18089325 |
PAPP-A level is elevated in renal transplant patients and high levels of PAPP-A may be a prognostic marker associated with high serum levels of urea, creatinine, uric acid, and C-reactive protein. |
| 17509577 |
Maternal serum PAPP-A levels in the late first trimester of pregnancy are associated with subsequent fetal growth,both physiologic variation and abnormal growth. |
| 17700210 |
PAPP-A IVS6+95 C allele is an independent risk factor for acute myocardial infarction even after adjustment for traditional risk factors. |
| 17437322 |
Maternal systemic lupus erythematosus does not affect first trimester level. |
| 15647258 |
the proform of eosinophil major basic protein inhibits the proteolytic activity of PAPP-A |
| 16963045 |
Preliminary evidence suggests that first-trimester uterine artery Doppler measurements do not correlate with maternal serum levels of free beta-hCG and PAPP-A. |
| 17145752 |
PAPP-A requires the formation of intermolecular proteinase-inhibitor disulfide bonds and glycosaminoglycan covalently bound to the inhibitor |
| 11897673 |
phorbol ester tumor promoters and simian virus 40 transformation regulate IGFBP-4 proteolysis in human fibroblasts through induction of a novel inhibitor of PAPP-A, pro-MBP |
| 12524241 |
Elevated serum PAPP-A levels represent a potential marker of the degree of echogenicity of carotid atherosclerotic plaques in asymptomatic hyperlipidemic patients at high cardiovascular risk. |
| 15262980 |
PAPPA Lin12-notch repeats bind calcium and determine its proteolytic specificity |
| 16086443 |
maternal serum PAPP-A at 11-13(+6) of gestation is significantly lower in adverse pregnancy outcomes |
| 17516846 |
Phage display was used to discover fully human antibody inhibitors of PAPP-A activity towards IGFBP4 cleavage |
| 15146551 |
PAPP-A and proMBP are regulated in malignant ovarian epithelial cells,altering IGFBP-4 proteolysis and local regulation of IGF availability |
| 14657012 |
PAPP-A expression is regulated by inflammatory cytokines in adult human fibroblasts, with functional consequences on IGFBP-4 protease activity and IGF-I bioavailability |
| 16388849 |
We suggest that PPARgamma-mediated inhibition of PAPP-A might decrease the amount of bioactive IGFII, a factor known to promote trophoblast invasion. |
| 15919757 |
PAPP-A functions in the formation of mineralized tissues through direct up-regulation of key genes and is involved in the formation of new blood vessels, which is essential for proper bone regeneration |
| 12414897 |
data demonstrate the presence of an IGF-II- and metal-dependent IGFBP-4 protease activity in human trophoblast plasma membranes, identified as PAPP-A |
| 15305104 |
women who experienced spontaneous abortions had significantly different mean PAPP-A serum levels at 10(+1) to 14(+6) weeks gestation |
| 14988014 |
Proform of eosinophil major basic protein forms a covalent complex with PAPPA in which PAPPA is inhibited. |
| 15754336 |
findings underscore a novel mechanism whereby glucocorticoids increase IGF responses in bone cells via PAPP-A-induced IGFBP-4 proteolysis |
| 12087395 |
association of maternal PAPP-A levels and fetal growth/birth weight |
| 14530192 |
Plasma PAPP-A, a zinc-binding matrix metalloproteinase, is a strong independent predictor of ischemic cardiac events and need of revascularization in patients who present with suspected myocardial infarction but remain troponin negative |
| 12370176 |
IGF bioactivity is regulated by reversible cell surface binding of PAPP-A, which in turn is regulated by proMBP |
| 16959807 |
PAPP-A may be involved in the regulation of bone development in the first trimester. |
| 17237617 |
We demonstrated that after successful TX, PAPP-A and sRAGE decrease and early chronic vascular changes in the kidney TX are associated with elevation of their serum levels. |
| 12421832 |
PAPP-A's structure is described, and its ability to dimerize and to bind to pro-major basic protein with disulfide bonds explained |
| 12241545 |
substrate specificity of the metalloproteinase pregnancy-associated plasma protein-A (PAPP-A) assessed by mutagenesis and analysis of synthetic peptides |
| 12213189 |
the PAPP-A mRNA level in mouse placenta was lower compared to that in human placenta by at least two orders of magnitude |
| 16115888 |
PAPP-A increased the proliferation and differentiation of myoblasts, its myogenic effect is governed by its proteolytic activity, and it promotes skeletal myogenesis by increasing the amount of free IGFs. |
| 12817760 |
TGF-beta and IGF-II in the bone microenvironment coordinately amplify IGF-I bioavailability through controlled IGFBP-4 protease, which may be a means to promote bone formation. |
| 17177834 |
the IGF system may have a limited role in the pathogenesis of GCT with PAPP-A subserving a function other than IGFBP-4 proteolysis |
| 17314100 |
PAPP-A2 LNR1-2, but not LNR3, are functionally conserved with respect to insulin-like growth factor -binding proteins proteolysis |
| 17565927 |
PAPP-A may contribute to airway smooth muscle hyperplasia |
| 11914564 |
Fetal trisomies 21, 18, and 13 are associated with a reduction in second-trimester maternal PAPP-A levels |
| 14705967 |
Partially purified PAPP-A400 exhibited a 4-fold reduction in IGFBP-4 proteolytic activity compared with PAPP-A470. A novel mechanism, conversion of PAPP-A470 to the less-active PAPP-A400, could account for the TPA-induced suppression of PAPP-A activity. |
| 12970325 |
PAPP-A may play an important role in an integrated insulin-like growth factor system in wound healing and tissue remodeling in vivo |
