Monday November 9 2009 | Biotechnology feed | All feeds

BioPortfolio Biotechnology Pharmaceutical Healthcare Medical Life Science Drug Discovery Disease

PARK2


Suggest Content
Advertise Here
Gene DB Home
Symbol:PARK2
Name(s):Parkinson disease (autosomal recessive, juvenile) 2, parkin
Type:protein-coding
Organism:Homo sapiens
Synonyms:AR-JP, LPRS2, PDJ, PRKN
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18211709 Observational study of genotype prevalence. (HuGE Navigator)
18211709 This study found mutations in PRKN genes. Seven of the studied patients showed pathogenic mutations, in homozygosity or compound heterozygosity for PRKN.
18003639 document the influence of Parkin on Pink1 subcellular distribution, providing further evidence for a common pathogenic pathway in recessive Parkinson's disease
12973932 Observational study of gene-disease association. (HuGE Navigator)
12975291 Observational study of gene-disease association. (HuGE Navigator)
14639672 Observational study of gene-disease association. (HuGE Navigator)
14737177 Observational study of gene-disease association. (HuGE Navigator)
15108293 Observational study of gene-disease association. (HuGE Navigator)
15192821 Observational study of gene-disease association. (HuGE Navigator)
15261877 Observational study of gene-disease association. (HuGE Navigator)

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDcaspase 1 isoform alpha precursorparkin isoform 1--Pubmed
HPRDG protein-coupled receptor 37Parkin--Pubmed
HPRDG protein-coupled receptor 37parkin isoform 1--Pubmed
HPRDN-methyl D-aspartate receptor subunit 2Bparkin isoform 1--Pubmed
HPRDN-methyl-D-aspartate receptor subunit 2B precursorParkin--Pubmed
HPRDParkinalpha-synuclein isoform NACP140--Pubmed
HPRDParkinseptin 5--Pubmed
HPRDParkinubiquitin-conjugating enzyme E2G 1--Pubmed
HPRDParkinubiquitin-conjugating enzyme E2L 3 isoform 1--Pubmed
HPRDParkincalcium/calmodulin-dependent serine protein kinase--Pubmed

Recent Publications on PARK2:

Pubmed Logo
Mapping preclinical compensation in Parkinson's disease: An imaging genomics approach.
Mutations in the Parkin (PARK2) and PINK1 gene (PARK 6) can cause...
31st October, 2009
Department of Neurology, Donders Institute for Brain, Cognition and Mov Disord. 2009 Oct 28;24(S2):S703-S710.
DOI Direct Link
Prevalence and clinical features of LRRK2 mutations in patients with Parkinson's disease in southern Spain.
BACKGROUND AND PURPOSE: Mutations in leucine-rich repeat kinase 2 (LRRK2)...
20th October, 2009
Laboratorio de Investigaciones Biomedicas,, Servicio de Neurologia, Eur J Neurol. 2009 Aug;16(8):957-60. Epub 2009 Mar 31.
DOI Direct Link
Genome wide DNA-profiling of HIV-related B-cell lymphomas.
Summary Non-Hodgkin lymphomas (NHL) represent a frequent complication of...
17th October, 2009
Division of Haematology, Department of Clinical and Experimental Medicine Br J Haematol. 2009 Oct 12.
DOI Direct Link
Loss of parkin or PINK1 function increases Drp1-dependent mitochondrial fragmentation.
Loss-of-function mutations in the parkin gene (PARK2) and PINK1 gene...
7th October, 2009
Neurobiochemistry, Deutsches Zentrum fur Neurodegenerative Erkrankungen J Biol Chem. 2009 Aug 21;284(34):22938-51. Epub 2009 Jun 22.
DOI Direct Link
Expression changes of dopaminergic system-related genes in PC12 cells induced by manganese, silver, or copper nanoparticles.
Nanoparticles have received a great deal of attention for producing new...
29th September, 2009
Neurochemistry Laboratory, Division of Neurotoxicology, National Center Neurotoxicology. 2009 Sep 23.
DOI Direct Link

View more research publications.

Clinical Trials:

Clinical Trials Logo
Clinical, Molecular and Metabolic Characteristics of Parkinson's Disease (PD) Patients With Parkin Mutation

Patents:

Patents logo
US Patent No.Title
7588771 Microorganisms for therapy
7588767 Microorganisms for therapy
7544786 Polynucleotide
7291461 Methods for identifying small molecules that modulate premature translation termination and nonsense mRNA decay
7208313 Combined growth factor-deleted and thymidine kinase-deleted vaccinia virus vector

View more patents.

PARK2 results (if any) from reagent suppliers

Google CSE Logo
PARK2 (Parkin) Antibody (C-term)
Abgent develops powerful tools to profile posttranslational modifications related to cellular function and disease. Abgent antibodies target protein
kinases ...
http://www.abgent.com/products/catalog_no/AP6402b_PARK2_Park...

Thumbshot
Parkin antibody, Parkin Antibody, Rabbit Polyclonal Antibody
Rabbit polyclonal to Parkin; FRA6E PARK 2 PARK2 PRKN; E3 ubiquitin-protein ligase parkin, PRKN2_HUMAN. [ N/A NP_004553.2 O60260 ].
http://www.genwaybio.com/product_info.php?products_id=196411...

Thumbshot
Antibodies to E1,E2,E3 Ligase
Park2(56816) mouse ... Park2(50873), mouse, rat, human, IHC, WB, pricing ... Park2(50873) rat ... Park2(56816), rat, human, mouse, hamster, ARR, WB, pricing
...
http://www.sigmaaldrich.com/etc/controller/controller-page.h...

Thumbshot
Parkin (PRK8) Antibody sc-32282
Human, PARK2, 5071, 6q26, NM_004562, NM_013987, NM_013988 · O60260 · 607572. Mouse, Park2, 50873, 17 A1, Q9WVS6, N/A. Ordering Information ...
http://www.scbt.com/datasheet-32282-parkin-prk8-antibody.htm...

Thumbshot
P6248 Monoclonal Anti-Parkin antibody produced in mouse ~2 mg/mL ...
isotype, IgG2b. Gene Information, human ... PARK2(5071). rat ... Park2(56816). mouse ... Park2(50873). shipped in, dry ice. storage temp. −20°C ...
http://www.sigmaaldrich.com/catalog/ProductDetail.do?D7=0&N5...

Thumbshot
Protein Modification - Ubiquitination Antibody
AT3158aNEW, OTUB1 monoclonal antibody (M09), ELISA,WB-Ce, H. AT3182aNEW, PARK2 monoclonal antibody (M01), ELISA,IF,WB-Ce,WB-Re, H ...
http://www.abgent.com/products/category/protein_modification...

Thumbshot
P1-PC
WH0005071M1, Monoclonal Anti-PARK2 antibody produced in mouse, 1H4 ..... Park2( 50873) rat ... Park2(56816), rat, human, mouse, hamster, ARR, WB, pricing ...
http://www.sigmaaldrich.com/etc/controller/controller-page.h...

Thumbshot

Search Bioportfolio and other Life Science Sites for PARK2, or search for PARK2 on BioPortfolio's antibody search engine.
This page has been viewed 760 times
Recent Search Terms used to find this page:
PARK2 GENE PRODUCTS RELATED TO PINK1 | parkinson s disease PARK2 mutation | gene caspase parkinson patent | Park2 mutation | parkin gene in juvenile parkinson s | park2 gene mutation | autosomal recessive juvenile Parkinson s disease | 2009 US Patent 7,544,786 | parkin gene | .


Resources from the NCBI used on this page, NCBI's standard disclaimer applies.

 

Nothing in this website should be used in place of personal medical advice from your own qualified medical practitioner.

All rights reserved. All other trademarks recognized.
Copyright 1997-2009 - BioPortfolio Limited.