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PARN
Gene Information from Publications |
| Publication Link |
Summary of findings |
| 16281054 |
The crystal structure of C-terminal truncated human PARN determined in two states (free and RNA-bound forms) reveals that PARN is folded into two domains, an R3H domain and a nuclease domain |
| 15358788 |
study of binding and coordination of divalent metal ions in the active site of PARN |
| 11742007 |
residues of human PARN, Asp(28), Glu(30), Asp(292), and Asp(382), are essential for catalysis but are not required for stabilization of the PARN x RNA substrate complex. |
| 17391638 |
The entire RNA-recognition motif (RRM) domain not only contributes to the substrate binding and efficient catalysis of PARN, but also stabilizes the overall structures of the protein. |
| 16601207 |
CUG-BP binds specifically to both of these RNAs and stimulates poly(A) shortening by PARN. Moreover, CUG-BP interacts with PARN in extracts by coimmunoprecipitation, and this interaction can be recapitulated using recombinant proteins |
| 16317009 |
Association of CBC with PARN might have importance in the regulated recruitment of PARN to the nonsense-mediated decay pathway during the pioneer round of translation. |
| 12748283 |
Results show that tristetraprolin can promote the deadenylation of AU-rich element (ARE)-containing, polyadenylated substrates by poly(A) RNase. |
| 11424938 |
Xenopus oocytes contain cytoplasmic (p62) and nuclear (p74) isoforms of PARN. p62 is proteolytically derived from p74. Both isoforms are expressed throughout oogenesis and early development. |
| 11359775 |
The m7GpppG cap has multiple effects on PARN activity. In cis, the 5'cap stimulates deadenylation by increasing PARN processivity. In trans, low concentrations of cap stimulate PARN activity whereas high concentrations inhibit deadenylation. |
| 9736620 |
PARN is a poly(A)-specific member of the RNase D family of 3' exoribonucleases. It is distributed between the nucleus and the cytoplasm and is not stably associated with ribosomes. Xenopus PARN catalyzes deadenylation during oocyte maturation. | →View more information from publications. |
Recent Publications on PARN: |  |
Do distinct populations of dorsal root ganglion neurons account for the sensory peptidergic innervation of the kidney?
Peptidergic afferent renal nerves (PARN) have been linked to kidney damage... | 21st August, 2009
| Department of Internal Medicine 4, Nephrology, and Hypertension,
| Am J Physiol Renal Physiol. 2009 Nov;297(5):F1427-34. Epub 2009 Aug 19.
DOI Direct Link |
Sex-specific fitness correlates of dispersal in a house sparrow metapopulation.
1. Dispersal affects many important ecological and evolutionary processes.... | 14th August, 2009
| Department of Biology, Centre for Conservation Biology, Norwegian
| J Anim Ecol. 2009 Nov;78(6):1216-25. Epub 2009 Aug 6.
DOI Direct Link |
Competitive inhibition of human poly(A)-specific ribonuclease (PARN) by synthetic fluoro-pyranosyl nucleosides.
Poly(A)-specific ribonuclease (PARN) is a cap-interacting deadenylase that... | 14th August, 2009
| Department of Biochemistry & Biotechnology, University of Thessaly, 26
| Biochemistry. 2009 Jul 7;48(26):6044-51.
DOI Direct Link |
Inhibition of human poly(A)-specific ribonuclease (PARN) by purine nucleotides: kinetic analysis.
Poly(A)-specific ribonuclease (PARN) is a cap-interacting and... | 6th August, 2009
| Department of Biochemistry and Biotechnology, University of Thessaly,
| J Enzyme Inhib Med Chem. 2009 Apr;24(2):516-23.
DOI Direct Link |
Second-generation de novo design: a view from a medicinal chemist perspective.
For computational de novo design, a general retrospective validation work... | 30th June, 2009
| Center for Bioinformatics, University of Hamburg, Bundesstrasse 43, 20146,
| J Comput Aided Mol Des. 2009 Jun 27.
DOI Direct Link |
→View more research publications. |
PARN results (if any) from reagent suppliers | 
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