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SERPINA5
| Symbol: | SERPINA5 | | Name(s): | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | PAI3, PCI, PLANH3, PROCI | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 15377716 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18193533 |
In human renal tissues, PCI and urinary plasminogen activator colocalized in the cytoplasm of renal proximal tubular epithelial cells |
| 17258797 |
PAI-3, but not PAI-1 or uPA, may have a role in breast cancer survival by suppression of tumor invasion through protease inhibition in stroma |
| 17450526 |
anti-angiogenic activity of PCI was strong as cleaved antithrombin, and slightly stronger than that of plasminogen activator inhibitor-1 and pigment epithelium-derived factor |
| 15878512 |
PCI may be involved in regulating key serine proteases involved in metastatic prostate disease |
| 17332248 |
exposure of oxidized PE and/or PS may be important for the local regulation of protein C inhibitor activity in vivo |
| 11864713 |
Role of each Asn-linked glycan in the anticoagulant activity of human protein C inhibitor. |
| 14696115 |
Protein C inhibitor regulates the invasive potential of renal cell carcinoma by inhibiting urinary plasminogen activator secreted by these cells |
| 11686324 |
PCI can up regulate TAFI activation by inhibiting the protein C activation. PCI may therefore be an important regulator in the balance between coagulation and fibrinolysis by differentially inhibiting the activation of TAFI and of protein C. |
Interacting gene products |
| Interaction Type |
Gene 1 |
Gene 2 |
Interaction description |
Complex |
Publication Link |
| HPRD | acrosin precursor | serine proteinase inhibitor, clade A, member 5 | - | - | Pubmed |
| HPRD | acrosin precursor | serine proteinase inhibitor, clade A, member 5 | - | - | Pubmed |
| HPRD | prostate specific antigen isoform 1 preproprotein | serine proteinase inhibitor, clade A, member 5 | - | - | Pubmed |
| HPRD | prostate specific antigen isoform 1 preproprotein | serine proteinase inhibitor, clade A, member 5 | - | - | Pubmed |
| HPRD | Prothrombin | serine proteinase inhibitor, clade A, member 5 | - | - | Pubmed |
| HPRD | Coagulation factor X | serine proteinase inhibitor, clade A, member 5 | - | - | Pubmed |
| HPRD | coagulation factor X preproprotein | Protein C inhibitor | - | - | Pubmed |
| HPRD | platelet coagulation factor XI precursor | serine proteinase inhibitor, clade A, member 5 | - | - | Pubmed |
| HPRD | platelet coagulation factor XI precursor | serine proteinase inhibitor, clade A, member 5 | - | - | Pubmed |
| HPRD | fibrinogen, alpha polypeptide isoform alpha-E preproprotein | serine proteinase inhibitor, clade A, member 5 | - | - | Pubmed |
Recent Publications on SERPINA5: |  |
Developmentally regulated SMAD2 and SMAD3 utilization directs activin signaling outcomes.
Activin is required for testis development. Activin signals via... | 25th September, 2009
| Department of Biochemistry &Molecular Biology, Monash University,
| Dev Dyn. 2009 Jul;238(7):1688-700.
DOI Direct Link |
Altered expression of HSPA5, HSPA8 and PARK7 in spinocerebellar ataxia type 17 identified by 2-dimensional fluorescence difference in gel electrophoresis.
BACKGROUND: Expansion of the CAG repeat of the TATA-box binding protein... | 14th February, 2009
| Department of Life Science, National Taiwan Normal University, Taipei,
| Clin Chim Acta. 2009 Feb;400(1-2):56-62. Epub 2008 Oct 30.
DOI Direct Link |
Sex differences in thrombosis in mice are mediated by sex-specific growth hormone secretion patterns.
Sex differences in thrombosis are well described, but their underlying... | 26th September, 2008
| Cardiovascular Research Institute, Department of Medicine, Division of
| J Clin Invest. 2008 Aug;118(8):2969-78.
DOI Direct Link |
The mouse testis is the source of various serine proteases and serine proteinase inhibitors (SERPINs): Serine proteases and SERPINs identified in Leydig cells are under gonadotropin regulation.
The occurrence of various serine proteinases and serine proteinases... | 22nd September, 2006
| Institut National de la Sante et de la Recherche Medicale, Unite 418,
| Endocrinology. 2006 Sep;147(9):4374-83. Epub 2006 Jun 1.
DOI Direct Link |
SERPINA5 results (if any) from reagent suppliers | 
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PAI-3 (P-15) Antibody sc-34496
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, SERPINA5, 5104, 14q32.13, NM_000624
...
http://www.scbt.com/datasheet-34496-pai-3-p-15-antibody.html...
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Quantikine Human Kallikrein 3/PSA Immunoassay
SerpinA5. SerpinC1. SerpinD1. SerpinE1/PAI-1. SerpinF2. Tryptase g-1/TPSG1. uPA. Recombinant mouse: SerpinC1. Spinesin. Other proteins: a2-Macroglobulin ...
http://www.rndsystems.com/pdf/DKK300.pdf...
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PAI-3 (M-17) Antibody sc-34495
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Mouse, Serpina5, 268591, 12 E, P70458 ...
http://www.scbt.com/datasheet-34495-pai-3-m-17-antibody.html...
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Triple Point Biologics, Inc. | Serine Proteinase Inhibitors
Human Serpin A4 (serine proteinase inhibitor clade A member 4, Kallistatin); SerpinA5. Human Serpin A5 (serine proteinase inhibitor clade A member 5, ...
http://www.triplepointbiologics.com/category.php?category_id...
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PAI-3 (P-15) Antibody sc-34496
种属, 基因名称, 基因ID, 染色质位置, 亚型（mRNA）即位号码, 蛋白质即位号码, OMIM™ 号码. 人类, SERPINA5, 5104, 14q32.13, NM_000624 · P05154 ...
http://www.scbt.com/zh/datasheet-34496-pai-3-p-15-antibody.h...
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PAI-3 (P-15) Antibody sc-34496
Humano, SERPINA5, 5104, 14q32.13, NM_000624 · P05154 · 601841. Ratón, Serpina5, 268591, 12 E, P70458, No Aplicable. Información sobre pedidos ...
http://www.scbt.com/es/datasheet-34496-pai-3-p-15-antibody.h...
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