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APH1A
Gene Information from Publications |
| Publication Link |
Summary of findings |
| 12297508 |
These data indicate that mammalian APH-1 (mAPH-1) along with presenilin 1 and nicastrin is probably a functional component of the gamma-secretase complex required for the intramembrane proteolysis of APP and Notch |
| 12972157 |
Six different polymorphisms have been determined but the polymorphisms in APH-1a/b coding regions are not linked to higher risk for Alzheimer disease in an Italian population. |
| 14593096 |
APH-1 can be processed by several endoproteolytic events and generates a stable C-terminal fragment that associates with nicastrin |
| 15210705 |
Only the combined overexpression of presenilin 1 and nicastrin together with APH-1a G122D facilitated the formation of a fully active gamma-secretase complex |
| 17059559 |
Over-expression of APH-1 and inhibition of proteasomal APH-1 degradation facilitated gamma-secretase cleavage of APP to generate Abeta. Thus,degradation of APH-1 protein is mediated by the ubiquitin-proteasome pathway. |
| 12471034 |
APH-1 binds to presenilins and nicastrin and may play a role in maturation of presenilin-nicastrin complexes |
| 12917438 |
APH-1 and the gamma-secretase complex bind to the transmembrane domain region of nicastrin |
| 15629423 |
knock down of APH-1a, but not APH-1b, resulted in impaired maturation of nicastrin and reduced expression of presenilin 1, presenilin 2, and PEN-2 proteins |
| 16757808 |
These results collectively indicate that the three forms of APH-1 can replace each other in presenilin (PS) complexes and that the transmembrane GxxxG region is essential for the stability of the APH-1 protein as well as the assembly of PS complexes. |
| 12763021 |
Expression of APH-1A increases amyloid beta peptide levels and gamma-secretase activity. | →View more information from publications. |
APH1A results (if any) from reagent suppliers | 
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APH1a antibody (ab12104) | Abcam
Rabbit polyclonal to APH1a. Anterior Pharynx Defective 1 (APH1a) is an integral transmembrane protein forming a component of the gamma-secretase complex, ...
http://www.abcam.com/APH1a-antibody-ab12104.html...
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Polyclonal Antibodies :: Page 17
APH1 Antibody, 4003, H, M, R, E, WB, IHC, (IN) a component of the presenilin complex. APH1A Antibody, 45-262, H, M, R, E, WB, APH1A ...
http://www.prosci-inc.com/shop/catalog1/Polyclonal-Antibodie...
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APH1a antibody - N-terminal (ab60119) | Abcam
Rabbit polyclonal to APH1a - N-terminal. Anterior Pharynx Defective 1 (APH1a) is an integral transmembrane protein forming a component of the ...
http://www.abcam.com/APH1a-antibody-N-terminal-ab60119.html...
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Cancer Antibodies :: Page 6
APBA1 Antibody, 45-260, H, M, R, E, WB, APBA1 / MINT1. APBB1 Antibody, 45-261, H , E, WB, APBB1 / FE65. APH1A Antibody, 45-262, H, M, R, E, WB, APH1A ...
http://www.prosci-inc.com/shop/catalog1/Cancer-Antibodies-p-...
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APH1a antibodies: Neuroscience > Neurology process > Notch Pathway ...
APH1a antibodies. ... APH1a antibody - Aminoterminal end. WB. Images. Rabbit polyclonal. Reacts with: Hu, Ms. ab60119 · APH1a antibody - N-terminal ...
http://www.abcam.com/index.html?t=65632&pt=1&c=406&ei=&mu=ra...
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Aph-1 (N-20) Antibody sc-30240
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, APH1A, 51107, 1q21.2, NM_016022 ...
http://www.scbt.com/datasheet-30240-aph-1-n-20-antibody.html...
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Purified Anti-Phospho-presenilin Ser 353/Ser357 Antibody - BioLegend
... Catenin beta, CDK5, Caspase 1, Bcl 2, MAPT, PKC?, Filamin A, Caspase 8, BCLX , Caspase 3, Caspase 6-8, Nicastrin, FBW7, APH1A, APH1B, PEN-2. Antigen ...
http://www.biolegend.com/purified-anti-phospho-presenilin-se...
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