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PCSK5


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Symbol:PCSK5
Name(s):proprotein convertase subtilisin/kexin type 5
Type:protein-coding
Organism:Homo sapiens
Synonyms:PC5, PC6, PC6A, SPC6
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18039650 after stimulation, the protease activity of PC5A is enhanced, as evidenced by the cleavage of the PC5A substrates Lefty, ADAMTS-4, endothelial lipase, and PCSK9.
15522936 PC5/6 plays a key role for decidualization in human endometrium.
16912035 PCSK9 levels are finely regulated by the basic amino acid convertases furin and PC5/6A
15601911 PC6 is an essential molecule in modulating uterine function to support the establishment of embryo implantation
15911696 furin and PC5 play a role in a MT-MMP-MMP-2 proteolytic cascade, involving provision of macrophage MT1-MMP for the activation of pro-MMP-2; furin and PC5 are expressed in monocytes and colocalize with MT1-MMP in macrophages in the atherosclerotic plaque
11723118 we investigated the specificity and potency of complete prodomains and short C-terminal prodomain peptides of each SPC on highly purified, soluble enzyme preparations of human SPC1, SPC6, and SPC7.
17242158 in binding VEGFR-2, furin and PC5 promote cleavage of N-and C-terminal VEGF-D propeptides, whereas PC7 promotes cleavage of the C-terminal propeptide only

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDAnti mullerian hormoneproprotein convertase subtilisin/kexin type 5 preproprotein--Pubmed
HPRDanti-Mullerian hormoneProprotein convertase subtilisin/kexin type 5--Pubmed
HPRDproprotein convertase subtilisin/kexin type 5 preproproteinrenin precursor--Pubmed
HPRDproprotein convertase subtilisin/kexin type 5 preproproteinrenin precursor--Pubmed

Recent Publications on PCSK5:

Pubmed Logo
Novel regulators of Fgf23 expression and mineralization in Hyp bone.
We used gene array analysis of cortical bone to identify Phex-dependent...
27th June, 2009
The Kidney Institute, University of Kansas Medical Center, Kansas City, Mol Endocrinol. 2009 Sep;23(9):1505-18. Epub 2009 Jun 25.
DOI Direct Link
Hormonal regulation of proprotein convertase subtilisin/kexin type 5 expression during ovarian follicle development in the rat.
The proprotein convertase subtilisin/kexin (PCSKs), a family of...
20th March, 2009
Hormone Research Center and School of Biological Sciences & Technology, Mol Cell Endocrinol. 2008 Jul 16;289(1-2):29-37. Epub 2008 Apr 22.
DOI Direct Link
Dynamic changes in messenger RNA profiles of bovine endometrium during the oestrous cycle.
During the oestrous cycle, the bovine endometrium exhibits characteristic...
30th August, 2008
Institute of Molecular Animal Breeding and Biotechnology, LMU Munich, Reproduction. 2008 Feb;135(2):225-40.
DOI Direct Link
VACTERL/caudal regression/Currarino syndrome-like malformations in mice with mutation in the proprotein convertase Pcsk5.
We have identified an ethylnitrosourea (ENU)-induced recessive mouse...
5th August, 2008
Department of Cardiovascular Medicine and Wellcome Trust Centre for Human Genes Dev. 2008 Jun 1;22(11):1465-77.
DOI Direct Link
In vivo functions of the proprotein convertase PC5/6 during mouse development: Gdf11 is a likely substrate.
The proprotein convertase PC5/6 cleaves protein precursors after basic...
14th June, 2008
Laboratory of Biochemical Neuroendocrinology, Clinical Research Institute Proc Natl Acad Sci U S A. 2008 Apr 15;105(15):5750-5. Epub 2008 Mar 31.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
7588771 Microorganisms for therapy
7588767 Microorganisms for therapy
7251568 Methods and compositions for regulating bone and cartilage formation
7208313 Combined growth factor-deleted and thymidine kinase-deleted vaccinia virus vector

PCSK5 results (if any) from reagent suppliers

Google CSE Logo
Lefty (M-20) Antibody sc-7408
VACTERL/caudal regression/Currarino syndrome-like malformations in mice with mutation in the proprotein convertase Pcsk5. Genes Dev. 22: 1465-1477. ...
http://www.scbt.com/datasheet-7408-lefty-m-20-antibody.html...

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BIOMOL International - Boc-RVRR-AMC, Fluorogenic Substrate
... SPC2/PC2/PCSK2, SPC3/PCSK1, PACE4/SPC4/PCSK6, SPC5/PC4/PCSK4, SPC6/PC5/PC6/ PCSK5, and SPC7/LPC/PC7/PC8/PCSK7. Can be used on live cells2. ...
http://www.biomol.com/?pageId=38&categoryId=311&productId=90...

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PC Antibody / PC Antibodies
PRODUCT NAME, CATALOG #, ISOTYPE, EPITOPE, APPLICATIONS, SPECIES. PC2 (H-20) Antibody, sc-22891, goat IgG, internal (h), WB, IP, IF, ELISA, m, r, h, ...
http://www.scbt.com/table-pc.html...

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PC Antibody / PC Antibodies
제품명, 카탈로그 번호, ISOTYPE, EPITOPE, APPLICATIONS, SPECIES. PC2 (H-20) Antibody, sc-22891, goat IgG, internal (h), WB, IP, IF, ELISA, m, r, h, ...
http://www.scbt.com/ko/table-pc.html...

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PC5/6 (T-19) Antibody sc-22900
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, PCSK5, 5125, 9q21.13, NM_006200 ...
http://www.scbt.com/ko/datasheet-22900-pc5-6-t-19-antibody.h...

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