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PDGFRB
| Symbol: | PDGFRB | | Name(s): | platelet-derived growth factor receptor, beta polypeptide | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | CD140B, JTK12, PDGF-R-beta, PDGFR, PDGFR1 | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 15380338 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18077793 |
Genetic deletion of PDGF-B or PDGFR-beta results in an absent glomerular mesangium [REVIEW] |
| 17568996 |
Dual targeting of IGF-1R and PDGFR increased cell death in both glioma 18 and glioma 38 cell lines in comparison to inhibition of either receptor alone. In addition, co-inhibition of IGF-1R and PDGFR increased radiosensitivity in 18 cells. |
| 17991872 |
Tissue Factor/Activated Factor VII complex transactivates PDGFRbeta to regulate PDGF-BB-induced chemotaxis of monocytes and fibroblasts |
| 17584975 |
Thymosin beta4 downregulated the expression of platelet-derived growth factor-beta receptor mRNAs in hepatic stellate cells. |
| 17727656 |
Diminished PDGFR-beta synthesis in Chlamydia pneumoniae infected cultures was accompanied by the suppression of AoSMC growth following PDGF-BB stimulation. |
| 17145809 |
The PDGFRB was highly expressed and phosphorylated with the absence of gain-of-function mutations and the presence of the cognate ligands, strongly support the hypothesis that the activation mechanism is the autocrine/paracrine loop in chordoma. |
| 17599906 |
The inhibition of Akt and S6K1 phosphorylation by PRR5 knock down correlates with reduction in the expression level of platelet-derived growth factor receptor beta (PDGFRbeta). |
| 17620338 |
Cbl-dependent negative regulation of PDGFRbeta involves a dual mechanism that concurrently promotes ubiquitin-dependent lysosomal sorting of the receptor and competitively reduces the recruitment of a positive mediator of receptor signaling |
| 17301821 |
Gene rearrangement found in a case of underlying chronic myelomonocytic leukaemia in Noonan Syndrome. | →View more information from publications. |
Recent Publications on PDGFRB: |  |
Frequent deletion of CDKN2A and recurrent coamplification of KIT, PDGFRA, and KDR in fibrosarcoma of bone-An array comparative genomic hybridization study.
Very little is known about the genetics of fibrosarcoma (FS) of bone. We... | 29th October, 2009
| Department of Pathology, Haartman Institute and HUSLAB, University of
| Genes Chromosomes Cancer. 2009 Oct 27.
DOI Direct Link |
[Classification of myeloid leukemias]
Myeloid leukemia in this series corresponds to the myeloid neoplasms of... | 29th October, 2009
| Hematoimmunology, School of Health Science, Faculty of Medicine,
| Nippon Rinsho. 2009 Oct;67(10):1853-62.
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The World Health Organization (WHO) Classification of Tumors of the Hematopoietic and Lymphoid Tissues: An overview with emphasis on the myeloid neoplasms.
The World Health Organization (WHO) classification of myeloid and lymphoid... | 28th October, 2009
| University of Chicago Medical Center, 5841 South Maryland Avenue, Chicago,
| Chem Biol Interact. 2009 Oct 23.
DOI Direct Link |
Expression and mutational status of PDGFR in thymic tumours.
BACKGROUND: There is an ongoing search for new therapeutic targets in... | 23rd October, 2009
| Translational Research Unit, Thoraxklinik-Heidelberg gGmbH, University of
| Anticancer Res. 2009 Oct;29(10):4057-61.
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The 2008 World Health Organization classification system for myeloproliferative neoplasms: order out of chaos.
The first formal classification of chronic myeloid neoplasms is credited... | 2nd October, 2009
| Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA.
| Cancer. 2009 Sep 1;115(17):3842-7.
DOI Direct Link |
→View more research publications. |
PDGFRB results (if any) from reagent suppliers | 
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mouse CD140b antibody, Functional Grade™ Purified conjugate
16-1402, Functional Grade* Purified anti-mouse CD140b (PDGFRb) ... PDGFRb is a receptor tyrosine kinase that forms dimers on the surface upon ligand binding
...
http://www.ebioscience.com/ebioscience/specs/antibody_16/16-...
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PDGFRB Antibody (C-term L1089)
PDGFRB Antibody (C-term L1089) Cell Function, PDGFRB Antibody (C-term L1089) Nuclear Signaling, PDGFRB Antibody (C-term L1089) Protein Modification, PDGFRB
...
http://www.abgent.com/products/catalog_no/AP7667b...
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PDGF Receptor b Antibody
whereas PDGFRb binds only PDGF B and D (1). PDGFRa and PDGFRb not only form homo - and ... region of PDGFRb is the docking site for PI3 kinase (5). ...
http://www.cellsignal.com/pdf/3162.pdf...
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PDGFRB Antibody (N-term)
PDGFRB Antibody (N-term) Cell Function, PDGFRB Antibody (N-term) Nuclear Signaling, PDGFRB Antibody (N-term) Protein Modification, PDGFRB Antibody (N-
term) ...
http://www.abgent.com/products/catalog_no/AP7667a...
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HTScan® PDGF Receptor b Kinase Assay Kit
region of PDGFRb is the docking site for PI3 kinase (5). Phosphorylated pentapeptides derived ... PI3 kinase with PDGFRb (6). Tyr740 is also required
for ...
http://www.cellsignal.com/pdf/7770.pdf...
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PE Anti-human CD140b PDGFRbeta Antibody Anti-CD140b - BioLegend
Other Names: Platelet-derived growth factor receptor, beta polypeptide, PDGFR1, PDGFRβ, PDGFRb, PDGF receptor beta. Structure: Cell surface tyrosine kinase ...
http://www.biolegend.com/pe-anti-human-cd140b-pdgfrbeta-anti...
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Platelet Derived Growth Factor Receptor (PDGFR)
human ... PDGFRB(5159), human, ELISA (i), FACS, IHC, Neutral, WB, pricing ... human ... PDGFRB(5159), human, pig, ARR, IHC (f), IP, WB, pricing ...
http://www.sigmaaldrich.com/etc/controller/controller-page.h...
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