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ABCB1


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Symbol:ABCB1
Name(s):ATP-binding cassette, sub-family B (MDR/TAP), member 1
Type:protein-coding
Organism:Homo sapiens
Synonyms:ABC20, CD243, CLCS, GP170, MDR1, MGC163296, P-gp, PGY1
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17963743 Examine interactions of agents used to treat attention-deficit/hyperactivity disorder with P-glycoprotein.
17943188 Pgp is involved in migration and invasion of resistant melanoma cells.
18279661 MDR1(+) cells had higher ability to form spheres in low attachment conditions, a hallmark of cancer. In conclusion, these novel findings imply that the MDR1(+) cells represent melanoma stem cells.
18214345 Observational study of gene-disease association and pharmacogenomic / toxicogenomic. (HuGE Navigator)
18215618 Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator)
18221820 Observational study of gene-disease association and pharmacogenomic / toxicogenomic. (HuGE Navigator)
18223457 Observational study of genotype prevalence. (HuGE Navigator)
18223462 Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator)
18240903 Observational study of genotype prevalence. (HuGE Navigator)
18243305 Observational study of gene-disease association. (HuGE Navigator)

View more information from publications.

Recent Publications on ABCB1:

Pubmed Logo
Accumulation of Eu(3+) chelates in cells expressing or not P-glycoprotein: Implications for blood-brain barrier crossing.
Alzheimer's disease (AD) is the most commonly form of dementia in the...
31st October, 2009
Laboratoire des Acides Nucleiques et Biophotonique, FRE 3207 CNRS, UMPC J Inorg Biochem. 2009 Oct 1.
DOI Direct Link
Laboratory correlates for a phase II trial of romidepsin in cutaneous and peripheral T-cell lymphoma.
Summary Romidepsin has shown promise in the treatment of T-cell lymphomas,...
31st October, 2009
Medical Oncology Branch, National Institutes of Health, Bethesda, MD, USA. Br J Haematol. 2009 Oct 28.
DOI Direct Link
Population Pharmacokinetics and Pharmacogenetics of Tacrolimus in De Novo Pediatric Kidney Transplant Recipients.
The aim of this study was to develop a population pharmacokinetic model of...
30th October, 2009
Department of Pediatric Pharmacology and Pharmacogenetics, Hopital Robert Clin Pharmacol Ther. 2009 Oct 28.
DOI Direct Link
Association of Molecular Markers With Toxicity Outcomes in a Randomized Trial of Chemotherapy for Advanced Colorectal Cancer: The FOCUS Trial.
PURPOSE: Predicting efficacy and toxicity could potentially allow...
28th October, 2009
Oncology & Clinical Research and Pathology & Tumour Biology Sections, J Clin Oncol. 2009 Oct 26.
DOI Direct Link
Balancing efficacy and toxicity of kidney transplant immunosuppression.
Late renal allograft loss is mainly the result of progressive histological...
28th October, 2009
Department of Nephrology and Renal Transplantation, University Hospitals Transplant Proc. 2009 Oct;41(8):3393-5.
DOI Direct Link

View more research publications.

Press Releases on ABCB1:

BioPortfolio Logo
Cequent tkRNAi Technology to be Presented at the Centennial Meeting of the American Association for Cancer Research 15th April, 2009 Cequent Pharmaceuticals, Inc.

Monday poster honored with special recognition awarded to top-rated abstracts

CAMBRIDGE, Mass., April 15 /PRNewswire/ -- Cequent Pharmaceuticals, a pioneer in the development of

BioNews Results for ABCB1

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BioPortfolio Logo
Sequence variations of ABCB1, SLC6A2, SLC6A3, SLC6A4, CREB1, CRHR1 and NTRK2: association with major depression and antidepressant response in Mexican-Americans
Molecular Psychiatry Journal:  Oct 20 2009 4:57PM Matching: abcb1

Clinical Trials:

Clinical Trials Logo
Antimetabolite Induction, High-Dose Alkylating Agent Consolidation and Retroviral Transduction of the MDR1 Gene Into Peripheral Blood Progenitor Cells Followed by Intensification Therapy With Sequential Paclitaxel and Doxorubicin for Stage 4 Breast Cancer

Patents:

Patents logo
US Patent No.Title
7408032 PRO1188 polypeptides
7425621 Antibodies against the PRO4401 polypeptide
7427667 PRO9835 antibodies
7429641 PRO9830 polypeptides
7432345 PRO1475 polypeptide

View more patents.

ABCB1 results (if any) from reagent suppliers

Google CSE Logo
ABCB1 Antibody ATP-Binding Cassette
Abcb1/MDR1/P glycoprotein is an ATP dependent transporter that mediates efflux of chemotherapeutic agents from the intracellular milieu. ...
http://www.prosci-inc.com/shop/catalog1/ABCB1-Antibody-p-322...

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P-Glycoprotein (ABCB1) Antibody (Center)
P-Glycoprotein (ABCB1) Antibody (Center) Cell Function, P-Glycoprotein (ABCB1) Antibody (Center) Cell Membrane, P-Glycoprotein (ABCB1) Antibody (Center) ...
http://www.abgent.com/products/catalog_no/AP6111a...

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ABCB1 Antibody ATP-Binding Cassette
ATP-Binding Cassette Sub-Family B Member 1 (ABCB1, also named P-glycoprotein) is a plasma membrane-associated multidrug transporter that utilizes the energy ...
http://www.prosci-inc.com/shop/catalog1/ABCB1-Antibody-p-325...

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human CD243 antibody, Functional Gradeā„¢ Purified conjugate
eBioscience technical data sheet for product 16-2439 Functional Grade Purified anti-human MDR1 (CD243, P-gp, P-glycoprotein, ABCB1) UIC2 antibody.
http://www.ebioscience.com/ebioscience/specs/antibody_16/16-...

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Polyclonal Antibodies :: Page 2
ABCB1 Antibody, 48-396, H, IHC, ATP-Binding Cassette. ABCB1 Antibody, 48-673, H, M, R, D, Mk, E, WB, IHC, ATP-Binding Cassette ...
http://www.prosci-inc.com/shop/catalog1/Polyclonal-Antibodie...

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Abgent Antibodies and Peptides
Catalog #. Target. Qualification. Specificity. AP6111a, ABCB1 Antibody (Center), H. AP6109a, ABCB10 Antibody (N-term), H. AP3018b, ABL Antibody (R432), H ...
http://www.abgent.com/docs/product_investigation...

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Homeostasis Antibodies :: Page 1
ABCB1 Antibody, 48-396, H, IHC, ATP-Binding Cassette. ABCC4 Antibody, 51-096, n/ a, WB, IHC, ATP-Binding Cassette, Sub-Family C ...
http://www.prosci-inc.com/shop/catalog1/Homeostasis-Antibodi...

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