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SERPINA1
| Symbol: | SERPINA1 | | Name(s): | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | A1A, A1AT, AAT, MGC23330, MGC9222, PI, PI1, PRO2275 | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18264947 |
Observational study of genotype prevalence. (HuGE Navigator) |
| 18309698 |
Meta-analysis of genotype prevalence. (HuGE Navigator) |
| 18028276 |
A1PI becomes a substrate for Basic carboxypeptidases |
| 18164971 |
Prevalence of common HFE and SERPINA1 mutations in patients with hepatocellular carcinoma in a Moroccan population. |
| 16501672 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16531799 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16608528 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16617455 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16802007 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16954950 |
Observational study of gene-disease association. (HuGE Navigator) | →View more information from publications. |
Interacting gene products |
| Interaction Type |
Gene 1 |
Gene 2 |
Interaction description |
Complex |
Publication Link |
| HPRD | chymotrypsinogen B1 | serine proteinase inhibitor, clade A, member 1 | - | - | Pubmed |
| HPRD | chymotrypsinogen B1 | serine proteinase inhibitor, clade A, member 1 | - | - | Pubmed |
| BIND | cathepsin G preproprotein | serine proteinase inhibitor, clade A, member 1 | Alpha-1 PI interacts with and inhibits cathepsin G. | - | Pubmed |
| BIND | elastase 2, neutrophil preproprotein | serine proteinase inhibitor, clade A, member 1 | Alpha-1 PI interacts with and inhibits neutrophil elastase. | - | Pubmed |
| BIND | low density lipoprotein-related protein 1 | serine proteinase inhibitor, clade A, member 1 | LRP interacts with alpha-1-PI. | - | Pubmed |
| HPRD | serine proteinase inhibitor, clade A, member 1 | protease, serine, 1 preproprotein | - | - | Pubmed |
| HPRD | serine proteinase inhibitor, clade A, member 1 | protease, serine, 1 preproprotein | - | - | Pubmed |
Recent Publications on SERPINA1: |  |
HDL antielastase activity prevents smooth muscle cell anoikis, a potential new antiatherogenic property.
Various studies using proteomic approaches have shown that HDL can carry... | 24th October, 2009
| INSERM U698, Paris, France.
| FASEB J. 2009 Sep;23(9):3129-39. Epub 2009 May 5.
DOI Direct Link |
Molecular characterization of the new defective P(brescia) alpha1-antitrypsin allele.
Alpha1-antitrypsin (alpha(1)AT) deficiency is a hereditary disorder... | 23rd October, 2009
| Department of Pathology, Spedali Civili/University of Brescia, Italy.
| Hum Mutat. 2009 Aug;30(8):E771-81.
DOI Direct Link |
Development and characterization of reference materials for MTHFR, SERPINA1, RET, BRCA1, and BRCA2 genetic testing.
Well-characterized reference materials (RMs) are integral in maintaining... | 22nd September, 2009
| Division of Laboratory Systems, Centers for Disease Control and
| J Mol Diagn. 2009 Nov;11(6):553-61. Epub 2009 Sep 18.
DOI Direct Link |
Development of novel microarray methodology for the study of mutations in the SERPINA1 and ADRB2 genes-Their association with Obstructive Pulmonary Disease and Disseminated Bronchiectasis in Greek patients.
OBJECTIVES: The aim of our study was to determine the genetic risk... | 15th September, 2009
| Department of Medical Genetics, Medical School, University of Athens,
| Clin Biochem. 2009 Sep 10.
DOI Direct Link |
Genetic modifiers of liver disease in cystic fibrosis.
CONTEXT: A subset (approximately 3%-5%) of patients with cystic fibrosis... | 15th September, 2009
| Cystic Fibrosis/Pulmonary Research and Treatment Center, University of
| JAMA. 2009 Sep 9;302(10):1076-83.
DOI Direct Link |
→View more research publications. |
SERPINA1 results (if any) from reagent suppliers | 
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SERPINA1 antibody, Alpha-1-antitrypsin Antibody, Chicken IgY ...
Buy quality chicken SERPINA1 antibody (interacts with human mouse rat), anti- SERPINA1, Alpha-1-antitrypsin antibody, chicken igy polyclonal antibody, ...
http://www.genwaybio.com/product_info.php?products_id=3...
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SERPINA1 Antibody a-1 antitrypsin
SERPINA1 antibody can be stored at 4C for short term (weeks) and -20C for long term.,
http://www.prosci-inc.com/shop/catalog1/SERPINA1-Antibody-p-...
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alpha 1 Antitrypsin antibody, alpha 1 Antitrypsin (ready-to-use ...
Rabbit Polyclonal to Alpha - 1 - Antitrypsin ( Prediluted ); 5265; SERPINA1; 107400; P01009; A1A; A1AT; AAT; MGC23330; MGC9222; PI; PI1; PRO2275;; ...
http://www.genwaybio.com/product_info.php?products_id=198143...
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Proteases
Serine proteinase inhibitor clade A member 1 (SERPINA1) polyclonal antibody, PAB -00019, $175.00. Serine proteinase inhibitor clade B member 10 (SERPINB10) ...
http://www.orbigen.com/dictionary/cat1061.htm...
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alpha 1 Antitrypsin antibody, alpha 1 Antitrypsin Antibody, Rabbit ...
Rabbit polyclonal to alpha 1 Antitrypsin; 5265; SERPINA1; 107400; P01009; A1A; A1AT; AAT; MGC23330; MGC9222; PI; PI1; PRO2275;; Alpha-1-antitrypsin, ...
http://www.genwaybio.com/product_info.php?products_id=197738...
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AAT (G-17) Antibody sc-14586
Human, SERPINA1, 5265, 14q32.13, NM_000295, NM_001002235, NM_001002236 · P01009 · 606963. Mouse, Serpina1a, 20700, 12 E, P07758 ...
http://www.scbt.com/datasheet-14586-aat-g-17-antibody.html...
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Serpina1a antibody, Sheep anti Alpha 1-Antitrypsin Antibody, Sheep ...
Variability within the reactive center loop (RCL) sequences of Serpina1-related genes may determine target protease specificity. ...
http://www.genwaybio.com/product_info.php?products_id=245526...
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