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PIGA
| Symbol: | PIGA | | Name(s): | phosphatidylinositol glycan anchor biosynthesis, class A (paroxysmal nocturnal hemoglobinuria) | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | GPI3, PIG-A | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 17823237 |
In patients with paroxysmal nocturnal hemoglobinuria, it is very unlikely that more than one PIG-A mutated clone arises at the level of the hematopoietic stem cells. |
| 12130519 |
Decreased susceptibility of leukemic cells with PIG-A mutation to natural killer cells in vitro allows paroxysmal nocturnal hemoglobinuria clones to escape immune attack. |
| 12037021 |
Molecular testing for mutations in the PIG-A gene can serve as a confirmation test of paroxysmal nocturnal hemoglobinuria. |
| 12411324 |
PIG-A gene abnormality in precursor cells and changes of expression of GPI-anchored protein and contribution of paroxysmal nocturnal hemoglobinuria clones with PIG-A gene abnormalities among various cell lineages during differentiation and maturation |
| 15687243 |
PIG-A mutations are relatively common in normal hematopoiesis |
| 16923549 |
review of the clinical and biological relevance of PIG-A mutations in paroxysmal nocturnal hemoglobinuria, aplastic anemia and healthy controls [review] |
| 12424196 |
The spectrum of PIG-A gene mutations in aplastic anemia/paroxysmal nocturnal hemoglobinuria reveals a high incidence of multiple mutations and evidence of a mutational hot spot. |
Recent Publications on PIGA: |  |
Convergent extension movements in growth plate chondrocytes require gpi-anchored cell surface proteins.
Proteins that are localized to the cell surface via... | 14th October, 2009
| Department of Biochemistry, Molecular Biology and Cell Biology,
| Development. 2009 Oct;136(20):3463-74. Epub 2009 Sep 17.
DOI Direct Link |
Experimental analysis and modelling of in vitro proliferation of mesenchymal stem cells.
OBJECTIVES: Stem cell therapies based on differentiation of adult or... | 9th October, 2009
| Department of Chemical Engineering and Materials Science, University of
| Cell Prolif. 2009 Oct;42(5):602-16. Epub 2009 Jul 10.
DOI Direct Link |
Severe iron overload in Blackfan-Diamond anemia: a case-control study.
Chronic iron overload is a serious complication in transfusion-dependent... | 8th October, 2009
| Department of Clinical and Biological Sciences, University of Torino,
| Am J Hematol. 2009 Nov;84(11):729-32.
DOI Direct Link |
Iron overload in patients receiving allogeneic hematopoietic stem cell transplantation: quantification of iron burden by superconducting quantum interference device (SQUID) and therapeutic effectiveness of phlebotomies.
Iron overload (IO) is an adverse prognostic factor in patients who undergo... | 22nd September, 2009
| Hematology 2 Unit, San Giovanni Battista Hospital and University, Turin.
| Biol Blood Marrow Transplant. 2009 Sep 17.
DOI Direct Link |
Efficacy and safety of deferasirox doses of >30 mg/kg per d in patients with transfusion-dependent anaemia and iron overload.
Summary The highest approved dose of deferasirox is currently 30 mg/kg per... | 22nd September, 2009
| American University of Beirut, Beirut, Lebanon.
| Br J Haematol. 2009 Sep 18.
DOI Direct Link |
→View more research publications. |
PIGA results (if any) from reagent suppliers | 
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Immunoglobulin Antibody / Immunoglobulin Antibodies
IgA (Hisa43) Antibody, sc-66185, mouse IgG1, FL (h), IP, IF, FCM, human. IgA ( PIgA-1) Antibody, sc-73596, mouse IgG2b, FL (pig), ELISA, pig ...
http://www.scbt.com/table-immunoglobulin.html...
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VPS35 antibody (ab10099) | Abcam
VPS35 is also required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA). The maintenance of organelles in eukaryotic cells ...
http://www.abcam.com/vps35-antibody-ab10099.html...
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IgA (PIgA-1) Antibody sc-73596
IgA (PIgA-1) 抗体 sc-73596 IgA (PIgA-1) Antibody sc-73596.
http://www.scbt.com/ja/datasheet-73596-iga-piga-1-antibody.h...
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GenWay Biotech, Inc.
Sansone G., Piga A.M. and Segni G. Il Favismo, Torino, Italy, Minerva Medica, 1958. 24.Kattamis C.A., Kyriazakou M. and Chaidas S. Favism : Clinical and ...
http://www.genwaybio.com/images/gw_tds/elisa_kits/40-056-205...
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PIG Protein Antibody / PIG Protein Antibodies
NOME DO PRODUTO, Numero de Catalogo, Isotipo, Epitopo, Uso e aplicacao, especie. PIG-A (C-17) Anticorpo, sc-49481, goat IgG, C-terminus (h), WB, IP, IF, ...
http://www.scbt.com/pt/table-pig_protein.html...
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Abcam antibodies and reagents product map
... 5, 7, 12 antibodies (1) · MPP1 antibodies (1) · Mitoferrin1 antibodies (1) · PIGA antibodies (1) · PIGA proteins and peptides (1) · WC15 antibodies (2) ...
http://www.abcam.com/index.html?c=253...
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PIG-A (C-17) Antibody sc-49481
Humain, PIGA, 5277, Xp22.2, NM_002641, NM_020473 · P37287 · 311770. Souris, Piga , 18700, X F5, Q64323, Non disponible ...
http://www.scbt.com/fr/datasheet-49481-pig-a-c-17-antibody.h...
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