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PIK3CA
| Symbol: | PIK3CA | | Name(s): | phosphoinositide-3-kinase, catalytic, alpha polypeptide | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | MGC142161, MGC142163, PI3K, p110-alpha | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18183466 |
PIK3CA mutations are common in invasive ductal carcinomas of the breast and PIK3CA exon 20 mutation is an independent risk factor for poor prognosis in breast cancer patients. |
| 18224685 |
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) |
| 17875942 |
Data suggest that PI3K-C2beta and AKT are epistatic to intersectin, and show that ITSN, independent of its role in endocytosis, regulates a critical cellular signaling pathway necessary for cell survival. |
| 18097548 |
PIK3CA mutations in HNSCC are likely to be oncogenic and may significantly contribute to HNSCC carcinogenesis and pave attractive target for therapeutic prevention. |
| 17986027 |
An impaired control of glycogen synthase kinase-3beta activity by insulin receptor-mediated signalling plays a role in the pathogenesis of AD, facilitating tau protein phosphorylation and neurofibrillary tangle formation. |
| 17468516 |
PI3K/ILK/Akt/NF-kappaB axis is a promising target for therapeutic intervention in renal cell carcinoma. |
| 15928251 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15994075 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16168105 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16317585 |
Observational study of gene-disease association. (HuGE Navigator) | →View more information from publications. |
Interacting gene products |
| Interaction Type |
Gene 1 |
Gene 2 |
Interaction description |
Complex |
Publication Link |
| HPRD | gamma-aminobutyric acid A receptor, beta 1 precursor | Phosphatidylinositol 3 kinase, catalytic subunit alpha | - | - | Pubmed |
| HPRD | guanine nucleotide binding protein, q polypeptide | phosphoinositide-3-kinase, catalytic, alpha polypeptide | - | - | Pubmed |
| HPRD | v-Ha-ras Harvey rat sarcoma viral oncogene homolog isoform 1 | Phosphatidylinositol 3 kinase, catalytic subunit alpha | - | - | Pubmed |
| HPRD | lymphocyte-specific protein tyrosine kinase | phosphoinositide-3-kinase, catalytic, alpha polypeptide | - | - | Pubmed |
| HPRD | Phosphatidylinositol 3 kinase, catalytic subunit alpha | Homo sapiens tumor endothelial marker 2 mRNA, complete cds. | - | - | Pubmed |
| HPRD | Phosphatidylinositol 3 kinase, catalytic subunit alpha | phosphoinositide-3-kinase, regulatory subunit, polypeptide 3 | - | - | Pubmed |
| HPRD | phosphoinositide-3-kinase, catalytic, alpha polypeptide | insulin receptor substrate 4 | - | - | Pubmed |
| BIND | phosphoinositide-3-kinase, catalytic, alpha polypeptide | adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 | APPL interacts with p110-alpha. | - | Pubmed |
Recent Publications on PIK3CA: |  |
PIK3CA in Breast Carcinoma: A Mutational Analysis of Sporadic and Hereditary Cases.
The PI3K-Akt cascade is a key signaling pathway involved in cell... | 29th October, 2009
| *Division of Surgical, Molecular and Ultrastructural Pathology, Department
| Diagn Mol Pathol. 2009 Oct 26.
DOI Direct Link |
AKT1 pleckstrin homology domain E17K activating mutation in endometrial carcinoma.
OBJECTIVES: The PI3K/AKT pathway is frequently activated in endometrial... | 27th October, 2009
| Department of Obstetrics and Gynecology, Sheba Medical Center,
| Gynecol Oncol. 2009 Oct 21.
DOI Direct Link |
FGFR3 and PIK3CA mutations in stucco keratosis and dermatosis papulosa nigra.
Summary Background Stucco keratosis (STK) and dermatosis papulosa nigra... | 23rd October, 2009
| Department of Dermatology, University of Regensburg,
| Br J Dermatol. 2009 Sep 1.
DOI Direct Link |
Phosphatidyl-inositol-3-kinase alpha catalytic subunit mutation and response to neoadjuvant endocrine therapy for estrogen receptor positive breast cancer.
Mutations in the alpha catalytic subunit of phosphoinositol-3-kinase... | 22nd October, 2009
| Department of Medicine, Washington University School of Medicine, St.
| Breast Cancer Res Treat. 2009 Oct 21.
DOI Direct Link |
Lapatinib monotherapy in patients with relapsed, advanced, or metastatic breast cancer: efficacy, safety, and biomarker results from Japanese patients phase II studies.
Background:HER2-positive metastatic breast cancer (MBC) relapsing after... | 22nd October, 2009
| [1] Department of Surgery, Graduate School of Medicine, Kyoto University,
| Br J Cancer. 2009 Oct 20.
DOI Direct Link |
→View more research publications. |
PIK3CA results (if any) from reagent suppliers | 
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Search Bioportfolio and other Life Science Sites for PIK3CA,
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