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PKM2
| Symbol: | PKM2 | | Name(s): | pyruvate kinase, muscle | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | CTHBP, MGC3932, OIP3, PK3, PKM, TCB, THBP1 | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 17406361 |
A sensitive and specific tumor marker for colorectal cancer, seen in older adults. |
| 17414054 |
An elevated level in this enzyme on admission in suspected periampullary cancer is a predictor of adverse prognosis in periampullary cancer. |
| 16132722 |
PanK4 interacts with Pkm2 and thereby may modulate the glucose metabolism through regulating the activity of Pkm2. |
| 17011640 |
PK can function as an autoimmune target and that this immunoreactivity may be associated with Tourette syndrome, obsessive compulsive disorder, and associated disorders |
| 15996096 |
The X-ray structure of tumor specific PKM2 complexed with Mg2+, K+, inhibitor oxalate, and allosteric activator fructose 1,6-bisphosphate has been determined, and its unique structural characteristics relative to other known isoforms have been analyzed. |
| 12820312 |
measurement of fecal Tumor M2-PK concentrations might provide an interesting screening tool for colorectal cancer |
| 12820320 |
With the fuzzy logic method and a tumor marker panel (including the new marker Tumor M2-PK), a useful diagnostic tool for the detection of progression in lung cancer patients is available |
| 12820337 |
phosphorylated at tyrosine residues in breast cancer patients; did not find any evidence that this phosphorylation is initiated by the oncoprotein HER-2/neu |
Recent Publications on PKM2: |  |
Pyruvate kinase isoenzyme M2 is a glycolytic sensor differentially regulating cell proliferation, cell size and apoptotic cell death dependent on glucose supply.
The glycolytic key regulator pyruvate kinase M2 (M2-PK or PKM2) can switch... | 2nd October, 2009
| Department of Cell Metabolism and Differentiation, Institute for
| Exp Cell Res. 2009 Oct 1;315(16):2765-74. Epub 2009 Jun 27.
DOI Direct Link |
A survey of proteins encoded by non-synonymous single nucleotide polymorphisms reveals a significant fraction with altered stability and activity.
On average, each human gene has approximately four SNPs (single nucleotide... | 26th August, 2009
| Structural Genomics Consortium, University of Toronto, 101 College Street,
| Biochem J. 2009 Oct 23;424(1):15-26.
DOI Direct Link |
Four-gene expression ratio test for survival in patients undergoing surgery for mesothelioma.
BACKGROUND: Malignant pleural mesothelioma has few effective treatments,... | 15th May, 2009
| Department of Surgery, Division of Thoracic Surgery, Harvard Medical
| J Natl Cancer Inst. 2009 May 6;101(9):678-86. Epub 2009 Apr 28.
DOI Direct Link |
Proteomic analysis of homocysteine induced proliferation of cultured neonatal rat vascular smooth muscle cells.
Hyperhomocysteinemia is a common independent risk factor for... | 24th March, 2009
| Department of Stress Medicine, Institute of Health and Environmental
| Biochim Biophys Acta. 2009 Feb;1794(2):177-84. Epub 2008 Oct 21.
DOI Direct Link |
The database dbEST correctly predicts gene expression in colon cancer patients.
This study aims to test the predictive power of gene expression data... | 10th March, 2009
| Leibniz Institute for Age Research - Fritz Lipmann Institute
| Curr Pharm Biotechnol. 2008 Dec;9(6):510-5.
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→View more research publications. |
PKM2 results (if any) from reagent suppliers | 
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