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PLAGL2


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Gene DB Home
Symbol:PLAGL2
Name(s):pleiomorphic adenoma gene-like 2
Type:protein-coding
Organism:Homo sapiens
Synonyms:FLJ23283
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17950244 This study thus uncovers a novel function of PLAGL2 as an oncoprotein through regulating the stability of Pirh2.
17618602 Nuclear PLAGL2 occupied and transactivated the endogenous SP-C promoter in hypoxic lung cells.These results further suggest that PLAGL2 is an oxidative stress responding regulator in lung cells.
17462995 These data clearly identify PLAGL2 as a novel regulator of NCF2/p67phox gene expression as well as NADPH oxidase activity and contribute to a greater understanding of the transcriptional regulation of NCF2.
15585652 Plag1 and Plagl2 are novel leukemia oncogenes that act by expanding hematopoietic progenitors expressing CbF beta-SMMHC.
15361364 PLAGL2 may modulate SP-C expression during lung development.

Recent Publications on PLAGL2:

Pubmed Logo
PLAGL2 expression-induced lung epithelium damages at bronchiolar alveolar duct junction in emphysema: bNip3- and SP-C-associated cell death/injury activity.
Emphysema and bronchitis are major components of chronic obstructive...
3rd September, 2009
Department of Internal Medicine, Pulmonary and Critical Care Medicine, Am J Physiol Lung Cell Mol Physiol. 2009 Sep;297(3):L455-66. Epub 2009 Jul
DOI Direct Link
Modulation of PLAGL2 transactivation activity by Ubc9 co-activation not SUMOylation.
Pleomorphic adenoma gene like-2 (PLAGL2), a developmentally regulated and...
6th September, 2008
Department of Internal Medicine, Pulmonary and Critical Care Medicine, UT Biochem Biophys Res Commun. 2008 Sep 26;374(3):570-5. Epub 2008 Jul 23.
DOI Direct Link
Tip60 modulates PLAGL2-mediated transactivation by acetylation.
Pleiomorphic adenoma gene (PLAG) family proteins are oncogenes involved in...
24th June, 2008
Department of Pharmacology and Cancer Center, School of Medicine, Case J Cell Biochem. 2008 Feb 15;103(3):730-9.
DOI Direct Link
Loss of the PlagL2 transcription factor affects lacteal uptake of chylomicrons.
Enterocytes assemble dietary lipids into chylomicron particles that are...
27th February, 2008
Department of Human Genetics, University of Leuven, B-3000 Leuven, Cell Metab. 2007 Nov;6(5):406-13.
DOI Direct Link
PLAGL2 controls the stability of Pirh2, an E3 ubiquitin ligase for p53.
PLAGL2 (Pleomorphic Adenoma Gene Like 2) is an oncoprotein involved in...
26th January, 2008
Department of Pharmacology and Cancer Center, School of Medicine, Case Biochem Biophys Res Commun. 2007 Dec 14;364(2):344-50. Epub 2007 Oct 11.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
7547687 Therapeutic treatment methods
7482334 Therapeutic treatment methods

PLAGL2 results (if any) from reagent suppliers

Google CSE Logo
Pleiomorphic adenoma gene-like 2 (PLAGL2) polyclonal antibody ...
Pleiomorphic adenoma gene-like 2 (PLAGL2) is a C2H2-type zinc finger protein that recognizes DNA and/or RNA. Its biological function remains unknown. ...
http://www.orbigen.com/commerce/catalog/product.jsp?product_...

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PLAGL2 siRNA (m) sc-38182
Click here for details. contact Technical Service for availability of control antibody; sqRT-PCR Primer also available: PLAGL2 (m)-PR: sc-38182-PR, 20 µl ...
http://www.scbt.com/ja/datasheet-38182-plagl2-sirna-m.html...

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Oncoproteins
Pleiomorphic adenoma gene-like 2 (PLAGL2) polyclonal antibody, PAB-01130, $175.00. transformed mouse 3T3 cell double minute 2, C-terminus (MDM2)
polyclonal ...
http://www.orbigen.com/dictionary/cat1054.htm...

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PLAG Antibody / PLAG Antibodies
PLAGL2 (C-16) Antibody, sc-19907, goat IgG, C-terminus (h), WB, IF, ELISA, m, r, h ... PLAGL2 shRNA Plasmid (h): sc-38181-SH. PLAGL2 shRNA (h) ...
http://www.scbt.com/ko/table-plag.html...

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PLAGL2 (C-16) Antibody sc-19907
PLAGL2 (C-16) 抗体sc-19907 PLAGL2 (C-16) Antibody sc-19907.
http://www.scbt.com/zh/datasheet-19907-plagl2-c-16-antibody....

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