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PLCB2
Gene Information from Publications |
| Publication Link |
Summary of findings |
| 15274049 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17429106 |
May constitute a molecular marker of breast tumor cells able to monitor the progression to invasive cancers and a target for novel therapeutic breast cancer strategies. |
| 17497434 |
Both PLC-beta2 isoforms are expressed at the protein level in platelets. In transfected CV-1 cells, PLC-beta2a is more enriched in the nuclei than PLC-beta2b. The two variants may have different effects in cell proliferation and differentiation. |
| 17478077 |
PLCB2 activity on actin-associated polyphosphoinositides promotes migration of differentiating tumoral myeloid precursors. |
| 12050180 |
up-regulated during granulocytic differenetiation of normal and leukemic hematopoietic progenitors |
| 16525635 |
Data indicate that PLC-beta2 expression correlates highly with breast cancer malignancy and suggest that it can be included, as an independent marker, among the prognostic indicators in current use. |
| 12388553 |
Conformation determines signal transduction of PLCB2 by Gbeta |
| 12054652 |
interacts with mitogen-activated protein kinase kinase 3. |
| 15509571 |
results support a model in which PLCbeta2 suppresses the basal catalytic activity of PLCdelta1, which is relieved by binding of Gbetagamma subunits to PLCbeta2 allowing for amplified calcium signals |
| 12657629 |
the recognition site for Rac GTPases was localized to the pleckstrin homology (PH) domain of PLC-beta2, and this PH domain is fully sufficient to selectively interact with the active versions of the Rac GTPases, but not with other similar Rho GTPases. | →View more information from publications. |
Interacting gene products |
| Interaction Type |
Gene 1 |
Gene 2 |
Interaction description |
Complex |
Publication Link |
| HPRD | Guanine nucleotide binding protein G(q) alpha subunit | phospholipase C, beta 2 | - | - | Pubmed |
| HPRD | guanine nucleotide binding protein, q polypeptide | Phospholipase C, beta 2 | - | - | Pubmed |
| HPRD | Phospholipase C, beta 2 | mitogen-activated protein kinase kinase 6 | - | - | Pubmed |
| HPRD | Phospholipase C, beta 2 | solute carrier family 9, isoform 3 regulator 1 | - | - | Pubmed |
| HPRD | Phospholipase C, beta 2 | transient receptor potential cation channel, subfamily M, member 7 | - | - | Pubmed |
| HPRD | phospholipase C, beta 2 | Solute carrier family 9, isoform A3, regulatory factor 1 | - | - | Pubmed |
| HPRD | phospholipase C, beta 2 | MAP2K6 | - | - | Pubmed |
| HPRD | phospholipase C, beta 2 | transient receptor potential cation channel, subfamily C, member 3 | - | - | Pubmed |
| HPRD | phospholipase C, beta 2 | mitogen-activated protein kinase kinase 3 isoform C | - | - | Pubmed |
| HPRD | phospholipase C, beta 2 | mitogen-activated protein kinase kinase 3 isoform C | - | - | Pubmed |
Recent Publications on PLCB2: |  |
Motile cilia of human airway epithelia are chemosensory.
Cilia are microscopic projections that extend from eukaryotic cells. There... | 10th September, 2009
| Department of Internal Medicine, University of Iowa, Iowa City, IA 52242,
| Science. 2009 Aug 28;325(5944):1131-4. Epub 2009 Jul 23.
DOI Direct Link |
A self-scaffolding model for G protein signaling.
Activation of heterotrimeric G proteins is generally believed to induce... | 5th May, 2009
| Department of Physiology and Biophysics, Stony Brook University, Stony
| J Mol Biol. 2009 Mar 20;387(1):92-103. Epub 2009 Jan 30.
DOI Direct Link |
CEACAM1 negatively regulates platelet-collagen interactions and thrombus growth in vitro and in vivo.
Carcinoembryonic antigen cell adhesion molecule-1 (CEACAM1) is a surface... | 2nd April, 2009
| Burnet Institute incorporating the Austin Research Institute, Heidelberg,
| Blood. 2009 Feb 19;113(8):1818-28. Epub 2008 Nov 13.
DOI Direct Link |
Colocalization of GPR120 with phospholipase-Cbeta2 and alpha-gustducin in the taste bud cells in mice.
A recent study has demonstrated that the G-protein coupled receptor GPR120... | 25th March, 2009
| Laboratory of Nutrition Chemistry, Division of Food Science and
| Neurosci Lett. 2009 Jan 30;450(2):186-90. Epub 2008 Dec 3.
DOI Direct Link |
Resynthesis of phosphatidylinositol 4,5-bisphosphate mediates adaptation of the caffeine response in rat taste receptor cells.
Caffeine, a prototypic bitter stimulus, produces several physiological... | 10th March, 2009
| College of Dentistry, Ohio State University, Columbus, OH 43210, USA.
| J Physiol. 2009 Jan 15;587(Pt 2):363-77. Epub 2008 Dec 1.
DOI Direct Link |
→View more research publications. |
PLCB2 results (if any) from reagent suppliers | 
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PLC β2 (Q-15) Antibody sc-206
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, PLCB2, 5330, 15q15.1, NM_004573 ...
http://www.scbt.com/datasheet-206-plc-beta2-q-15-antibody.ht...
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