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PLD2


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Symbol:PLD2
Name(s):phospholipase D2
Type:protein-coding
Organism:Homo sapiens
Synonyms:-
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
12601529 Observational study of gene-disease association. (HuGE Navigator)
17986621 These findings indicate the involvement of phospholipase D activation in hBD-2 up-regulation in gingival epithelial cells.
17640750 These results demonstrate for the first time that PLD1 and PLD2 isozymes enhance cobalt chlorde-induced COX-2 expression through differential signaling pathways in astroglioma cells.
17627030 Plays a major role in promoting HIV-1 long terminal repeat transactivation and virus replication.
17914593 Elevated phospholipase D2 is associated with colorectal carcinoma
17486115 Our findings establish a crucial role for PLD2 in the coupling of extracellular signals to Sos-mediated Ras activation, and provide new insights into the spatial coordination of this activation event.
17486117 Thus, LFA-1 acts through PLD2 to reshape the pattern of Ras activation downstream of the TCR
16118212 intracellular unsaturated acyl-CoA derivatives destabilize ABCA1 by activating a PLD2 signaling pathway
12782287 PLD isozymes stimulate cell growth by repressing expression of p21 gene
15798205 Phospholipase D2 (PLD2) enhances PKCzeta activity through direct interaction in a lipase activity-independent manner.

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDActin betaphospholipase D2--Pubmed
HPRDbeta actinPhospholipase D2--Pubmed
HPRDaldolase Aphospholipase D2--Pubmed
HPRDaldolase Aphospholipase D2--Pubmed
HPRDamphiphysin isoform 1phospholipase D2--Pubmed
HPRDamphiphysin isoform 1phospholipase D2--Pubmed
HPRDAmphiphysin IIphospholipase D2--Pubmed
HPRDbridging integrator 1 isoform 1Phospholipase D2--Pubmed
HPRDAquaporin 3phospholipase D2--Pubmed
HPRDaquaporin 3Phospholipase D2--Pubmed

Recent Publications on PLD2:

Pubmed Logo
EPIDERMAL GROWTH FACTOR INCREASES LYSOPHOSPHATIDIC ACID PRODUCTION IN HUMAN OVARIAN CANCER CELLS: ROLES FOR PHOSPHOLIPASE D2 AND RECEPTOR TRANSACTIVATION.
Lysophosphatidic acid (LPA), is a lipid mediator that binds to G-protein...
30th October, 2009
1Washington State University. Am J Physiol Cell Physiol. 2009 Oct 28.
DOI Direct Link
Role of Phospholipase D in Parathyroid Hormone Type 1 Receptor Signaling and Trafficking.
The role of phospholipase D (PLD) in the regulation of the traffic of the...
20th October, 2009
Department of Pharmacology and Chemical Biology (J.L.G., D.W., L.L.V., Mol Endocrinol. 2009 Oct 16.
DOI Direct Link
PLD2 has both enzymatic and cell proliferation-inducing capabilities, that are differentially regulated by phosphorylation and dephosphorylation.
Phospholipase D2 (PLD2) overexpression in mammalian cells results in cell...
15th October, 2009
Department of Biochemistry and Molecular Biology, Wright State University Biochem Biophys Res Commun. 2009 Nov 13;389(2):224-8. Epub 2009 Aug 26.
DOI Direct Link
Inter-regulatory dynamics of phospholipase D and the actin cytoskeleton.
Phospholipase D activity has been extensively implicated in the regulation...
8th October, 2009
The Inositide Laboratory, the Babraham Institute, Babraham Research Biochim Biophys Acta. 2009 Sep;1791(9):856-61. Epub 2009 May 5.
DOI Direct Link
Phospholipase d promotes lipid microdomain-associated signaling events in mast cells.
Initial IgE-dependent signaling events are associated with...
2nd October, 2009
Laboratory of Molecular Immunology, National Heart, Lung, and Blood J Immunol. 2009 Oct 15;183(8):5104-12. Epub 2009 Sep 30.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
7547687 Therapeutic treatment methods
6353026 Regulation of phospholipase D activity
6268840 Unipolar waveform drive method and apparatus for a bistable liquid crystal display
6187559 Phospholipase D gene
6163547 In-band signaling for a hand-over operation in a mobile telecommunication system

View more patents.

PLD2 results (if any) from reagent suppliers

Google CSE Logo
Anti-PC Specific PLD2, N-Terminal antibody produced in rabbit ...
PLD2 is PIP2-dependent but differs from PLD1 in that it exhibits high basal constitutive ... activity of PLD2 is approximately 1500 fold higher than ...
http://www.sigmaaldrich.com/etc/medialib/docs/Sigma/Datashee...

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PC-PLD Antibody / PC-PLD Antibodies
PC-PLD2 (N-20) Antibody, sc-18523, goat IgG, N-terminus (h), WB, IF, ELISA, human ... PC-PLD2 (V-20) Antibody, sc-48270, goat IgG, catalytic domain (h) ...
http://www.scbt.com/table-pc-pld.html...

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Anti-PC-Specific PLD1, N-Terminal antibody produced in rabbit ...
PLD2 is also PIP2-dependent but differs from PLD1 in that it exhibits a high basal constitutive ... generated against PLD1 and PLD2 are used to study ...
http://www.sigmaaldrich.com/etc/medialib/docs/Sigma/Datashee...

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PC-PLD2 siRNA (h) sc-44001
Click here for details. suitable control antibody: PC-PLD2 (N-20): sc-18523; sqRT-PCR Primer also available: PC-PLD2 (h)-PR: sc-44001-PR, 20 µl ...
http://www.scbt.com/ko/datasheet-44001-pc-pld2-sirna-h.html...

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Antibodies to Lipids in Cell Signaling
P5993, Anti-PC Specific PLD2, Internal antibody produced in rabbit, (polyclonal) ... Pld2(18806), mouse, WB, pricing. P6618, Anti-PC Specific PLD2, ...
http://www.sigmaaldrich.com/etc/controller/controller-page.h...

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PLD1 Antibody #3832
This antibody does not cross-react with PLD2. ... Two isoforms of PLD (PLD1 and PLD2) have been identified so far. Both are regulated by protein kinases, ...
http://www.cellsignal.com/products/3832.html...

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PC-PLD2 (H-133) Antibody sc-25513
PC-PLD2 (H-133) 抗体 sc-25513 PC-PLD2 (H-133) Antibody sc-25513.
http://www.scbt.com/ja/datasheet-25513-pc-pld2-h-133-antibod...

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