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Gclc
| Symbol: | Gclc | | Name(s): | Glutamate-cysteine ligase catalytic subunit | | Type: | protein-coding | | Organism: | Drosophila melanogaster | | Synonyms: | CG2259, DmGCLC, DmGCS, DmGCSh, GCSh, Gcs | | Links: |
Pubmed,
Entrez Gene,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18056974 |
that the longevity effects of GCLc are dependent on dosage and that there are specific tissues (mushroom bodies, motor neurons, and transverse muscle cells) particularly sensitive to the benefits of GCLc overexpression. |
| 16324789 |
The reversibility of the dephosphorylation-dependent activation was indicated by the time-dependent inactivation of the in vitro activated Drosophila GCL, by preincubation with MgATP. |
| 16148000 |
Neuronal overexpression of GCLc in a long-lived background extended mean and maximum life spans up to 50%, without affecting the rate of oxygen consumption by the flies |
| 12954617 |
investigation of mutations in GCL modifier subunit and the GCL catalytic subunit that modify catalytic activity and lower glutathione levels |
Gclc results (if any) from reagent suppliers | 
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GCLC peptide (ab41462) | Abcam
GCLC peptide. Gamma-glutamylcysteine synthetase catalyses the first step in the synthesis of glutathione. The enzyme is composed of a 73 kDa heavy chain and ...
http://www.abcam.com/Gamma-Glutamylcysteine-Synthetase-GCS-p...
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γ-GCSc (H-300) Antibody sc-22755
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, GCLC, 2729, 6p12.1, NM_001498 ...
http://www.scbt.com/datasheet-22755-gamma-gcsc-h-300-antibod...
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The Abcam catalog
GCLC antibodies. ... GCLC antibody - BSA and Azide free. IP, WB. Rabbit polyclonal. Reacts with: Hu, Ms, Rat, Cow, Mk. Predicted: CynMk, Xl, Zfsh ...
http://www.abcam.com/index.html?t=109843&pt=1&c=2252...
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Panorama® Antibody Array - Signal Transduction
GCLC. glutamate-cysteine ligase, catalytic subunit. 2729 · GEM. GTP binding protein overexpressed in skeletal muscle ...
http://www.sigmaaldrich.com/life-science/cell-biology/protei...
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GCLC proteins and peptides: Signal Transduction > Metabolism ...
GCLC proteins and peptides. ... GCLC proteins and peptides. Code. Name. Applications (see key) & Reactivity (see key). Image Abreview Publication ...
http://www.abcam.com/index.html?t=109843&pt=2&c=2252&ei=&mu=...
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Gamma Glutamylcysteine Synthetase (GCS) / Glutamate-cysteine ...
Immunogen: A synthetic peptide derived from corresponding to aa 295-313 of rat GCLC (heavy subunit of GCS). Positive Control:Jurkat, MAD109, PC12 cells ...
http://www.labvision.com/ab.cfm?first=AntiBody&second=1697...
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Mad 1 (C-19) Antibody sc-222
Identification of an E-box motif as a transcriptional repressor element in the proximal promoter region of the GCLC gene in rat lung epithelial L2 cells. ...
http://www.scbt.com/ko/datasheet-222-mad-1-c-19-antibody.htm...
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