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ACP5


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Symbol:ACP5
Name(s):acid phosphatase 5, tartrate resistant
Type:protein-coding
Organism:Homo sapiens
Synonyms:MGC117378, TRAP
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18285546 Observational study of gene-disease association. (HuGE Navigator)
17357281 TRAP 5b may serve as a new additional marker of bone resorption in the assessment of renal osteodystrophy.
17088078 This work suggests that tumour derived TRAP contributes to the raised enzyme activity found in the serum of breast cancer patients.
15950921 a role of the loop residue D158 in catalysis in the cleaved enzyme.
12589973 serum tartrate resistant tartrate resistant acid phosphatase 5 is useful as a marker for bone resorption
12901871 In human serum, TRACP 5b circulates in a large complex that contained alpha2M and calcium.
12845688 Increased tartrate-resistant acid phosphatase isoform 5b is associated with multiple myeloma bone disease
16200454 The results suggest that in endothelial cells of the afferent arterioles, mesangial cells, and lymphocytes the cellular activities are regulated by high constitutive phosphotyrosine phosphatase.
15701839 Elevated tartrate-resistant acid phosphatase 5b in serum is associted with extensive bone metastasis in breast cancer
15878315 Results lead to hypothesize that the capacity of osteoblast-like cells to endocytose TRACP (ACP5) is important for the removal of this enzyme during or following the bone resorptive activity of the osteoclast.

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDtartrate resistant acid phosphatase 5 precursorglypican 4--Pubmed

Recent Publications on ACP5:

Pubmed Logo
[Comparative transcriptome analysis of human aorta atherosclerotic lesions and peripheral blood leukocytes from essential hypertension patients.]
One of the major cardiovascular risk factor which predisposes to and...
24th September, 2009
Russian Cardiology Scientific and Production Center, ul. Tretiya Kardiologiia. 2009;49(9):27-38.
Characterization of a sub-family of Arabidopsis genes with the SPX domain reveals their diverse functions in plant tolerance to phosphorus starvation.
Four genes of Arabidopsis (At5g20150, At2g26660, At2g45130 and At5g15330)...
1st July, 2009
State Key Laboratory of Plant Physiology and Biochemistry, College of Life Plant J. 2008 Jun;54(6):965-75. Epub 2008 Feb 26.
DOI Direct Link
Defective co-activator recruitment in osteoclasts from microphthalmia-oak ridge mutant mice.
The three basic DNA-binding domain mutations of the...
15th May, 2009
Department of Molecular and Cellular Biochemistry, Comprehensive Cancer J Cell Physiol. 2009 Jul;220(1):230-7.
DOI Direct Link
Global age-dependent differences in gene expression in response to calvarial injury.
Children less than 2 years of age are capable of healing large calvarial...
17th January, 2009
Department of Surgery, Division of Plastic and Reconstructive Surgery, J Craniofac Surg. 2008 Sep;19(5):1292-301.
DOI Direct Link
Acid phosphatase 5 is responsible for removing the mannose 6-phosphate recognition marker from lysosomal proteins.
Most newly synthesized proteins destined for the lysosome reach this...
17th December, 2008
Center for Advanced Biotechnology and Medicine and Department of Proc Natl Acad Sci U S A. 2008 Oct 28;105(43):16590-5. Epub 2008 Oct 21.
DOI Direct Link

View more research publications.

Clinical Trials:

Clinical Trials Logo
Assessment of Tartrate-Resistant Acid Phosphatase (TRAP) as a Bone Resorption Marker in Stage IV Breast Cancer Patients With Bone Metastasis

Patents:

Patents logo
US Patent No.Title
6864073 Avermectin aglycon synthase genes
7211418 PUFA polyketide synthase systems and uses thereof
7217856 PUFA polyketide synthase systems and uses thereof
7235358 Methods and compositions for diagnosing and monitoring transplant rejection
7241613 Identification of Candida cell surface proteins and their uses

View more patents.

ACP5 results (if any) from reagent suppliers

Google CSE Logo
A8482 Anti-ACP5 (132-145) antibody produced in rabbit IgG fraction ...
A8482 Anti-ACP5 (132-145) antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution.
http://www.sigmaaldrich.com/catalog/ProductDetail.do?N4=A848...

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GeneTex Inc. - Your source for monoclonal, polyclonal, primary ...
ACP5 antibody (acid phosphatase 5, tartrate resistant), GTX100438, Rabbit PAb, WB, 100 μl, USD $269.00, -. ADORA2A antibody ...
http://www.genetex.com/WebPage/Product/Catalog.aspx?Type=Sea...

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TRAP (N-17) Antibody sc-30832
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, ACP5, 54, 19p13.2, NM_001611 ...
http://www.scbt.com/datasheet-30832-trap-n-17-antibody.html...

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Cytoskeleton/Cell Membrane/Cell Adhesion Research(1661) - GeneTex ...
ACP5 antibody (acid phosphatase 5, tartrate resistant), GTX100438, Rabbit PAb, WB, 100 μl, USD $269.00, -. ACVR1B antibody (activin A receptor, type IB) ...
http://www.genetex.com/WebPage/Product/Catalog.aspx?Type=Sea...

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Antibodies to Nicotinic Acetylcholine Receptors
Acp5(11433) human ... CHRNB1(1140) rat ... Chrnb1(24261), rat, mouse, eel, human , IHC (p), IP, WB, pricing. N8533, Monoclonal Anti-Nicotinic Acetylcholine ...
http://www.sigmaaldrich.com/etc/controller/controller-page.h...

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TRAP (h2): 293T Lysate sc-178082
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, ACP5, 54, 19p13.2, P13686 ...
http://www.scbt.com/datasheet-178082-trap-h2-293t-lysate.htm...

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Human Soluble Receptor Hematopoietic Panel Proteome Profiler Array
TRACP/PAP/ACP5. TRAP. 54. E13, E14. TRANCE/TNFSF11. CD254, RANKL. 8600. E15, E16 . TREM-1. ___. 54210. G1, G2. Positive Control ...
http://www.rndsystems.com/pdf/ARY011.pdf...

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